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gmk gmk apt apt A4SNE6_AERS4 A4SNE6_AERS4 gpt gpt guaC guaC A4SK59_AERS4 A4SK59_AERS4 purA purA gsk gsk add-2 add-2 guaA guaA guaB guaB A4SQV1_AERS4 A4SQV1_AERS4 cpdB cpdB ham1 ham1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (208 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
A4SNE6_AERS4Unannotated protein; Belongs to the 5'-nucleotidase family. (553 aa)
gptUnannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (155 aa)
guaCUnannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
A4SK59_AERS4Unannotated protein; Belongs to the 5'-nucleotidase family. (662 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa)
gskUnannotated protein. (434 aa)
add-2Unannotated protein; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (526 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
A4SQV1_AERS4Unannotated protein; Belongs to the 5'-nucleotidase family. (612 aa)
cpdBUnannotated protein; Belongs to the 5'-nucleotidase family. (659 aa)
ham1Unannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
Your Current Organism:
Aeromonas salmonicida
NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida
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