STRINGSTRING
pyk pyk nudF nudF purK purK purE purE accD accD apt apt udk udk atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB spoT spoT gmk gmk purT purT carB carB carA carA pfkA pfkA tpiA tpiA purL purL ndk ndk A4SPB2_AERS4 A4SPB2_AERS4 A4SPC1_AERS4 A4SPC1_AERS4 A4SPD2_AERS4 A4SPD2_AERS4 A4SPI9_AERS4 A4SPI9_AERS4 acsA-2 acsA-2 gppA gppA corC corC deoB deoB A4SJH5_AERS4 A4SJH5_AERS4 gpt gpt udp2 udp2 pgk pgk ribF ribF hpt hpt A4SN39_AERS4 A4SN39_AERS4 sucB sucB pyk-2 pyk-2 purF purF coaA coaA pyrB pyrB accC accC acsA acsA tpiA-2 tpiA-2 purU purU surE surE eno eno pyrG pyrG prsA prsA pyrF pyrF purA purA adk adk fliI fliI glk glk pykA pykA A4SKS8_AERS4 A4SKS8_AERS4 purB purB lfiI lfiI purE-2 purE-2 gpmI gpmI guaA guaA guaB guaB accA accA pyrH pyrH A4SQS1_AERS4 A4SQS1_AERS4 purC purC pta pta pyrD pyrD A4SM77_AERS4 A4SM77_AERS4 mazG mazG upp upp purM purM purN purN ppx ppx GCA_000820065_04046 GCA_000820065_04046 tesB tesB pyrE pyrE A4SS78_AERS4 A4SS78_AERS4 A4SS57_AERS4 A4SS57_AERS4 purD purD purH purH coaE coaE aceE aceE aceF aceF coaD coaD coaBC coaBC pgi pgi relA relA cyaA cyaA GCA_000820065_00852 GCA_000820065_00852 udp udp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pykUnannotated protein; Belongs to the pyruvate kinase family. (474 aa)
nudFUnannotated protein. (213 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (374 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
udkUnannotated protein. (214 aa)
atpCUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa)
atpDUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (462 aa)
atpGUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa)
atpAUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa)
atpHUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpFUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa)
atpEUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa)
atpBUnannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (259 aa)
spoTUnannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (208 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa)
carBUnannotated protein; Belongs to the CarB family. (1074 aa)
carAUnannotated protein; Belongs to the CarA family. (383 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
purLUnannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1305 aa)
ndkUnannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
A4SPB2_AERS4Unannotated protein. (120 aa)
A4SPC1_AERS4Unannotated protein. (156 aa)
A4SPD2_AERS4Unannotated protein; Belongs to the phosphoglycerate mutase family. (164 aa)
A4SPI9_AERS4Unannotated protein. (132 aa)
acsA-2Unannotated protein. (645 aa)
gppAUnannotated protein; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (496 aa)
corCUnannotated protein. (294 aa)
deoBUnannotated protein; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (402 aa)
A4SJH5_AERS4Unannotated protein. (456 aa)
gptUnannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (155 aa)
udp2Unannotated protein. (241 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (387 aa)
ribFUnannotated protein; Belongs to the ribF family. (324 aa)
hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa)
A4SN39_AERS4Unannotated protein. (137 aa)
sucBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (394 aa)
pyk-2Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa)
coaAUnannotated protein. (312 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
tpiA-2Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (278 aa)
surEUnannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (248 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
prsAUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa)
adkUnannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
fliIUnannotated protein. (443 aa)
glkUnannotated protein; Belongs to the bacterial glucokinase family. (322 aa)
pykAUnannotated protein; Belongs to the pyruvate kinase family. (479 aa)
A4SKS8_AERS4Unannotated protein. (206 aa)
purBUnannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
lfiIUnannotated protein. (446 aa)
purE-2Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (526 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
pyrHUnannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (244 aa)
A4SQS1_AERS4Unannotated protein. (133 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (382 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
A4SM77_AERS4Unannotated protein. (123 aa)
mazGUnannotated protein. (265 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
purMUnannotated protein. (345 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (224 aa)
ppxUnannotated protein; Belongs to the GppA/Ppx family. (496 aa)
GCA_000820065_04046Unannotated protein. (354 aa)
tesBUnannotated protein. (287 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (217 aa)
A4SS78_AERS4Unannotated protein. (202 aa)
A4SS57_AERS4Unannotated protein. (134 aa)
purDUnannotated protein; Belongs to the GARS family. (429 aa)
purHUnannotated protein. (530 aa)
coaEUnannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
aceEUnannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
aceFUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (630 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
coaBCUnannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
pgiUnannotated protein; Belongs to the GPI family. (549 aa)
relAUnannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (739 aa)
cyaAUnannotated protein; Belongs to the adenylyl cyclase class-1 family. (843 aa)
GCA_000820065_00852Unannotated protein. (390 aa)
udpUnannotated protein; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (251 aa)
Your Current Organism:
Aeromonas salmonicida
NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.