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accC accC acsA acsA thiL thiL dxs dxs cysZ cysZ metK metK gshB gshB metH metH thiC thiC thiE thiE thiS thiS thiG thiG thiH thiH cysM cysM GCA_000820065_00852 GCA_000820065_00852 bioD bioD bioC bioC bioF bioF bioB bioB bioA bioA cysK cysK ggt ggt accD accD asd asd A4SH69_AERS4 A4SH69_AERS4 mtnN mtnN thiI thiI cysC cysC metJ metJ kbl kbl A4SL41_AERS4 A4SL41_AERS4 pta pta A4SQP1_AERS4 A4SQP1_AERS4 cysN cysN A4SQJ5_AERS4 A4SQJ5_AERS4 A4SQJ0_AERS4 A4SQJ0_AERS4 accA accA cysD cysD cysE cysE metAS metAS bioH bioH acsA-2 acsA-2 A4ST70_AERS4 A4ST70_AERS4 lipA lipA A4SJZ4_AERS4 A4SJZ4_AERS4 GCA_000820065_02416 GCA_000820065_02416 GCA_000820065_02415 GCA_000820065_02415 cysH cysH A4SJH5_AERS4 A4SJH5_AERS4 A4SLM4_AERS4 A4SLM4_AERS4 gshA gshA metE metE asd-2 asd-2 folD folD spuC spuC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
thiLUnannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa)
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa)
cysZUnannotated protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (254 aa)
metKUnannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)
gshBUnannotated protein; Belongs to the prokaryotic GSH synthase family. (317 aa)
metHUnannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
thiCUnannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (668 aa)
thiEUnannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (524 aa)
thiSUnannotated protein. (70 aa)
thiGUnannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)
thiHUnannotated protein. (407 aa)
cysMUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
GCA_000820065_00852Unannotated protein. (390 aa)
bioDUnannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
bioCUnannotated protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (270 aa)
bioFUnannotated protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (398 aa)
bioBUnannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (362 aa)
bioAUnannotated protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (424 aa)
cysKUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
ggtUnannotated protein. (593 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
A4SH69_AERS4Unannotated protein. (270 aa)
mtnNUnannotated protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
thiIUnannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
cysCUnannotated protein; Catalyzes the synthesis of activated sulfate. (196 aa)
metJUnannotated protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. (107 aa)
kblUnannotated protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (365 aa)
A4SL41_AERS4Unannotated protein. (300 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa)
A4SQP1_AERS4Unannotated protein. (180 aa)
cysNUnannotated protein; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (471 aa)
A4SQJ5_AERS4Unannotated protein. (78 aa)
A4SQJ0_AERS4Unannotated protein. (146 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
cysDUnannotated protein. (322 aa)
cysEUnannotated protein. (259 aa)
metASUnannotated protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (314 aa)
bioHUnannotated protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (254 aa)
acsA-2Unannotated protein. (645 aa)
A4ST70_AERS4Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
lipAUnannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (326 aa)
A4SJZ4_AERS4Unannotated protein. (218 aa)
GCA_000820065_02416Unannotated protein. (294 aa)
GCA_000820065_02415Unannotated protein. (307 aa)
cysHUnannotated protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (260 aa)
A4SJH5_AERS4Unannotated protein. (456 aa)
A4SLM4_AERS4Unannotated protein. (277 aa)
gshAUnannotated protein; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (532 aa)
metEUnannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (760 aa)
asd-2Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (371 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
spuCUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (472 aa)
Your Current Organism:
Aeromonas salmonicida
NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida
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