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thrC thrC iscS iscS hdc hdc metB metB sufS sufS kbl kbl ilvE ilvE ilvA ilvA tnaA tnaA mdeA mdeA hisC hisC cysK cysK bioA bioA bioF bioF cysM cysM odc odc malP malP hemL hemL argD argD alr2 alr2 gcvP gcvP dsdA dsdA metY metY lysA lysA speA speA A4SRS0_AERS4 A4SRS0_AERS4 A4ST70_AERS4 A4ST70_AERS4 acdS acdS alr alr selA selA serC serC selA-2 selA-2 cadA cadA alr-2 alr-2 arnB arnB A4SJA0_AERS4 A4SJA0_AERS4 trpB trpB gabT gabT glyA glyA spuC spuC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thrCUnannotated protein. (424 aa)
iscSUnannotated protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa)
hdcUnannotated protein. (389 aa)
metBUnannotated protein. (390 aa)
sufSUnannotated protein; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (406 aa)
kblUnannotated protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (365 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (313 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (506 aa)
tnaAUnannotated protein; Belongs to the beta-eliminating lyase family. (461 aa)
mdeAUnannotated protein. (387 aa)
hisCUnannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa)
cysKUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
bioAUnannotated protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (424 aa)
bioFUnannotated protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (398 aa)
cysMUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
odcUnannotated protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (441 aa)
malPUnannotated protein; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (825 aa)
hemLUnannotated protein. (428 aa)
argDUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
alr2Unannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (408 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
dsdAUnannotated protein; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (443 aa)
metYUnannotated protein. (422 aa)
lysAUnannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa)
speAUnannotated protein; Catalyzes the biosynthesis of agmatine from arginine. (633 aa)
A4SRS0_AERS4Unannotated protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (233 aa)
A4ST70_AERS4Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
acdSUnannotated protein. (315 aa)
alrUnannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (367 aa)
selAUnannotated protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (489 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
selA-2Unannotated protein. (371 aa)
cadAUnannotated protein. (710 aa)
alr-2Unannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (357 aa)
arnBUnannotated protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (378 aa)
A4SJA0_AERS4Unannotated protein. (511 aa)
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
gabTUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (434 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
spuCUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (472 aa)
Your Current Organism:
Aeromonas salmonicida
NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida
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