(12 nodes) (2022) Comparative genomics analysis of the multidrug-resistant Aeromonas hydrophila MX16A providing insights into antibiotic resistance genes. network (Aeromonas salmonicida)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	gyrA	Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (934 aa)
	polB	Unannotated protein. (806 aa)
	folC	Unannotated protein; Belongs to the folylpolyglutamate synthase family. (415 aa)
	parC	Unannotated protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (775 aa)
	ampC	Unannotated protein. (382 aa)
	A4SK80_AERS4	Unannotated protein. (390 aa)
	folP	Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (281 aa)
	tolC	Unannotated protein. (441 aa)
	tolC-2	Unannotated protein. (441 aa)
	rpoB	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa)
	msbA	Unannotated protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (589 aa)
	acrA	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (379 aa)

Your Current Organism:

Aeromonas salmonicida

NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A4SK80_AERS4	ampC	GCA_000820065_00942	GCA_000820065_00941	Unannotated protein.	Unannotated protein.	0.418
acrA	tolC	GCA_000820065_04065	GCA_000820065_02137	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Unannotated protein.	0.799
acrA	tolC-2	GCA_000820065_04065	GCA_000820065_02982	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Unannotated protein.	0.988
ampC	A4SK80_AERS4	GCA_000820065_00941	GCA_000820065_00942	Unannotated protein.	Unannotated protein.	0.418
folC	folP	GCA_000820065_00743	GCA_000820065_01181	Unannotated protein; Belongs to the folylpolyglutamate synthase family.	Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.999
folP	folC	GCA_000820065_01181	GCA_000820065_00743	Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	Unannotated protein; Belongs to the folylpolyglutamate synthase family.	0.999
gyrA	parC	GCA_000820065_03912	GCA_000820065_00780	Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Unannotated protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	0.554
gyrA	rpoB	GCA_000820065_03912	GCA_000820065_03160	Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.860
parC	gyrA	GCA_000820065_00780	GCA_000820065_03912	Unannotated protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.554
parC	rpoB	GCA_000820065_00780	GCA_000820065_03160	Unannotated protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.692
polB	rpoB	GCA_000820065_00459	GCA_000820065_03160	Unannotated protein.	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.456
rpoB	gyrA	GCA_000820065_03160	GCA_000820065_03912	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.860
rpoB	parC	GCA_000820065_03160	GCA_000820065_00780	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Unannotated protein; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	0.692
rpoB	polB	GCA_000820065_03160	GCA_000820065_00459	Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Unannotated protein.	0.456
tolC	acrA	GCA_000820065_02137	GCA_000820065_04065	Unannotated protein.	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.799
tolC	tolC-2	GCA_000820065_02137	GCA_000820065_02982	Unannotated protein.	Unannotated protein.	0.500
tolC-2	acrA	GCA_000820065_02982	GCA_000820065_04065	Unannotated protein.	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.988
tolC-2	tolC	GCA_000820065_02982	GCA_000820065_02137	Unannotated protein.	Unannotated protein.	0.500