STRINGSTRING
fhs fhs arsC arsC A4SP40_AERS4 A4SP40_AERS4 gcvT gcvT gcvH gcvH gcvP gcvP mccF mccF A4SNW0_AERS4 A4SNW0_AERS4 tpiA tpiA pfkA pfkA serA serA rpiA rpiA fadJ fadJ atoB atoB sdaB sdaB sdaA sdaA fabV fabV rnfC rnfC ppsA ppsA accD accD A4SIH4_AERS4 A4SIH4_AERS4 pyk pyk cysK cysK A4SPS6_AERS4 A4SPS6_AERS4 GCA_000820065_00852 GCA_000820065_00852 GCA_000820065_00853 GCA_000820065_00853 glpX glpX tal tal tkt tkt sfcA sfcA maeA maeA eno eno A4SKI3_AERS4 A4SKI3_AERS4 fumC fumC GCA_000820065_01163 GCA_000820065_01163 tpiA-2 tpiA-2 glyA glyA acsA acsA accB accB accC accC serA-2 serA-2 arcC arcC ackA ackA folD folD pyk-2 pyk-2 gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD A4SNC0_AERS4 A4SNC0_AERS4 fumB fumB phaJ phaJ gap gap mdh mdh ppc ppc arsC-2 arsC-2 katE katE A4SRE1_AERS4 A4SRE1_AERS4 pgk pgk A4SK39_AERS4 A4SK39_AERS4 rpe rpe FABV_AERS4 FABV_AERS4 icd icd gapA gapA vagD vagD serB serB frdA frdA frdB frdB frdC frdC frdD frdD A4SJY4_AERS4 A4SJY4_AERS4 mmsA mmsA adhC adhC A4ST97_AERS4 A4ST97_AERS4 fbp fbp mmsA-2 mmsA-2 A4STG5_AERS4 A4STG5_AERS4 fadB fadB prsA prsA hyfA hyfA hydN hydN fdhF fdhF serC serC glk glk hexR hexR pykA pykA gntK gntK edd edd eda eda gpmI gpmI accA accA A4SQK4_AERS4 A4SQK4_AERS4 prkB prkB A4SR31_AERS4 A4SR31_AERS4 ackA-2 ackA-2 pta pta A4SM78_AERS4 A4SM78_AERS4 aceB aceB aceA aceA GCA_000820065_04046 GCA_000820065_04046 pdhA pdhA A4SKZ1_AERS4 A4SKZ1_AERS4 maeB maeB ilvA ilvA pckA pckA aceE aceE aceF aceF lpdA lpdA acnB acnB cysE cysE pgi pgi
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fhsUnannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (580 aa)
arsCUnannotated protein. (116 aa)
A4SP40_AERS4Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (620 aa)
gcvTUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (365 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
mccFUnannotated protein. (337 aa)
A4SNW0_AERS4Unannotated protein. (279 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
serAUnannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
rpiAUnannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (217 aa)
fadJUnannotated protein; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa)
atoBUnannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (334 aa)
sdaBUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
sdaAUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
fabVUnannotated protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (395 aa)
rnfCUnannotated protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (753 aa)
ppsAUnannotated protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (790 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
A4SIH4_AERS4Unannotated protein. (133 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (474 aa)
cysKUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
A4SPS6_AERS4Unannotated protein; Belongs to the ArsC family. (116 aa)
GCA_000820065_00852Unannotated protein. (390 aa)
GCA_000820065_00853Unannotated protein. (813 aa)
glpXUnannotated protein. (336 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
tktUnannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
sfcAUnannotated protein. (516 aa)
maeAUnannotated protein; Belongs to the malic enzymes family. (564 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
A4SKI3_AERS4Unannotated protein. (235 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (327 aa)
GCA_000820065_01163Unannotated protein. (131 aa)
tpiA-2Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (144 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
serA-2Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
arcCUnannotated protein; Belongs to the carbamate kinase family. (308 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
pyk-2Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (428 aa)
sdhCUnannotated protein. (129 aa)
sdhDUnannotated protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (114 aa)
sdhAUnannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (569 aa)
sdhBUnannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucAUnannotated protein. (936 aa)
sucBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (394 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
A4SNC0_AERS4Unannotated protein. (246 aa)
fumBUnannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
phaJUnannotated protein. (136 aa)
gapUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (877 aa)
arsC-2Unannotated protein. (143 aa)
katEUnannotated protein; Belongs to the catalase family. (482 aa)
A4SRE1_AERS4Unannotated protein. (89 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (387 aa)
A4SK39_AERS4Unannotated protein. (1177 aa)
rpeUnannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa)
FABV_AERS4Unannotated protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the NADH-dependent reduction of the carbon-carbon double bond in the enoyl moiety that is covalently linked to an acyl carrier protein (ACP). (397 aa)
icdUnannotated protein. (417 aa)
gapAUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (477 aa)
vagDUnannotated protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (133 aa)
serBUnannotated protein. (336 aa)
frdAUnannotated protein. (594 aa)
frdBUnannotated protein. (244 aa)
frdCUnannotated protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane; Belongs to the FrdC family. (132 aa)
frdDUnannotated protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (118 aa)
A4SJY4_AERS4Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
mmsAUnannotated protein. (498 aa)
adhCUnannotated protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
A4ST97_AERS4Unannotated protein; Serine hydrolase involved in the detoxification of formaldehyde. (278 aa)
fbpUnannotated protein. (344 aa)
mmsA-2Unannotated protein. (503 aa)
A4STG5_AERS4Unannotated protein. (165 aa)
fadBUnannotated protein; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (715 aa)
prsAUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
hyfAUnannotated protein. (231 aa)
hydNUnannotated protein. (229 aa)
fdhFUnannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (558 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
glkUnannotated protein; Belongs to the bacterial glucokinase family. (322 aa)
hexRUnannotated protein. (284 aa)
pykAUnannotated protein; Belongs to the pyruvate kinase family. (479 aa)
gntKUnannotated protein. (169 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (598 aa)
edaUnannotated protein. (213 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
A4SQK4_AERS4Unannotated protein. (335 aa)
prkBUnannotated protein. (289 aa)
A4SR31_AERS4Unannotated protein. (249 aa)
ackA-2Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa)
A4SM78_AERS4Unannotated protein. (132 aa)
aceBUnannotated protein. (535 aa)
aceAUnannotated protein. (437 aa)
GCA_000820065_04046Unannotated protein. (354 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (364 aa)
A4SKZ1_AERS4Unannotated protein. (328 aa)
maeBUnannotated protein. (418 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (506 aa)
pckAUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (541 aa)
aceEUnannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
aceFUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (630 aa)
lpdAUnannotated protein. (475 aa)
acnBUnannotated protein; Belongs to the aconitase/IPM isomerase family. (865 aa)
cysEUnannotated protein. (259 aa)
pgiUnannotated protein; Belongs to the GPI family. (549 aa)
Your Current Organism:
Aeromonas salmonicida
NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida
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