STRINGSTRING
BTO12_11525 BTO12_11525 rhlE rhlE BTO12_12325 BTO12_12325 BTO12_12870 BTO12_12870 BTO12_13355 BTO12_13355 BTO12_13840 BTO12_13840 BTO12_13865 BTO12_13865 BTO12_14435 BTO12_14435 rpsK rpsK rpsD rpsD rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ recF recF dnaA dnaA rpmH rpmH BTO12_08940 BTO12_08940 BTO12_08760 BTO12_08760 BTO12_17385 BTO12_17385 rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplM rplM rpsI rpsI BTO12_20435 BTO12_20435 srmB srmB BTO12_20040 BTO12_20040 rpsT rpsT raiA raiA cutC cutC guaB guaB BTO12_21810 BTO12_21810 dnaJ dnaJ BTO12_21980 BTO12_21980 BTO12_22075 BTO12_22075 GCA_001558055_04512 GCA_001558055_04512 BTO12_09765 BTO12_09765 rpmG rpmG rpmB rpmB BTO12_09670 BTO12_09670 slmA slmA dtd dtd rep rep BTO12_18430 BTO12_18430 BTO12_17915 BTO12_17915 BTO12_17885 BTO12_17885 BTO12_17640 BTO12_17640 BTO12_17695 BTO12_17695 BTO12_01135 BTO12_01135 BTO12_00965 BTO12_00965 BTO12_00750 BTO12_00750 BTO12_00645 BTO12_00645 ihfA ihfA BTO12_00230 BTO12_00230 BTO12_24640 BTO12_24640 rplY rplY GCA_001558055_02065 GCA_001558055_02065 BTO12_23860 BTO12_23860 BTO12_23850 BTO12_23850 ihfB ihfB BTO12_23785 BTO12_23785 BTO12_01475 BTO12_01475 BTO12_05365 BTO12_05365 BTO12_04155 BTO12_04155 BTO12_04035 BTO12_04035 rpsF rpsF rpsR rpsR rplI rplI BTO12_10290 BTO12_10290 BTO12_10545 BTO12_10545 rplL rplL rplJ rplJ rplA rplA rplK rplK BTO12_17270 BTO12_17270 BTO12_16015 BTO12_16015 BTO12_15965 BTO12_15965 BTO12_15700 BTO12_15700 BTO12_15520 BTO12_15520 BTO12_15485 BTO12_15485 BTO12_15305 BTO12_15305 BTO12_15255 BTO12_15255 BTO12_15245 BTO12_15245 deaD deaD BTO12_14710 BTO12_14710 recO recO rpsP rpsP BTO12_06630 BTO12_06630 infB infB rpsO rpsO BTO12_06275 BTO12_06275 BTO12_06200 BTO12_06200 rpmE2 rpmE2 rpsB rpsB dnaQ dnaQ BTO12_02360 BTO12_02360 BTO12_02365 BTO12_02365 BTO12_02415 BTO12_02415 rpmI rpmI BTO12_03895 BTO12_03895 rplQ rplQ BTO12_07475 BTO12_07475 BTO12_11035 BTO12_11035 nth nth rnfC rnfC rpmF rpmF topB topB recR recR BTO12_04885 BTO12_04885 hupB_1 hupB_1 rpsG rpsG rpmE rpmE priA priA fis fis hupA hupA rpsU rpsU dnaG dnaG GCA_001558055_00887 GCA_001558055_00887 rpmA rpmA rplU rplU BTO12_20905 BTO12_20905 matP matP cobB cobB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTO12_11525Unannotated protein. (206 aa)
rhlEUnannotated protein; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (551 aa)
BTO12_12325Unannotated protein. (594 aa)
BTO12_12870Unannotated protein. (457 aa)
BTO12_13355Unannotated protein; Belongs to the DEAD box helicase family. (429 aa)
BTO12_13840Unannotated protein. (392 aa)
BTO12_13865Unannotated protein. (259 aa)
BTO12_14435Unannotated protein. (314 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsDUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rplXUnannotated protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rplPUnannotated protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsCUnannotated protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (232 aa)
rplVUnannotated protein; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (110 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rplWUnannotated protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplDUnannotated protein; Forms part of the polypeptide exit tunnel. (200 aa)
rplCUnannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
recFUnannotated protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (359 aa)
dnaAUnannotated protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (475 aa)
rpmHUnannotated protein; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
BTO12_08940Unannotated protein; Belongs to the ParB family. (293 aa)
BTO12_08760Unannotated protein. (191 aa)
BTO12_17385Unannotated protein; Belongs to the ParB family. (324 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDUnannotated protein. (58 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplFUnannotated protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsNUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplEUnannotated protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (130 aa)
BTO12_20435Unannotated protein. (159 aa)
srmBUnannotated protein; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (421 aa)
BTO12_20040Unannotated protein. (381 aa)
rpsTUnannotated protein; Binds directly to 16S ribosomal RNA. (86 aa)
raiAUnannotated protein. (111 aa)
cutCUnannotated protein; Participates in the control of copper homeostasis. Belongs to the CutC family. (247 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
BTO12_21810Unannotated protein; May be involved in recombinational repair of damaged DNA. (554 aa)
dnaJUnannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] (381 aa)
BTO12_21980Unannotated protein; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (403 aa)
BTO12_22075Unannotated protein. (644 aa)
GCA_001558055_04512Unannotated protein. (347 aa)
BTO12_09765Unannotated protein. (349 aa)
rpmGUnannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
BTO12_09670Unannotated protein; Belongs to the UPF0758 family. (224 aa)
slmAUnannotated protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (196 aa)
dtdUnannotated protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
repUnannotated protein; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (672 aa)
BTO12_18430Unannotated protein. (246 aa)
BTO12_17915Unannotated protein. (206 aa)
BTO12_17885Unannotated protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
BTO12_17640Unannotated protein. (616 aa)
BTO12_17695Unannotated protein. (130 aa)
BTO12_01135Unannotated protein. (112 aa)
BTO12_00965Unannotated protein. (200 aa)
BTO12_00750Unannotated protein. (245 aa)
BTO12_00645Unannotated protein. (246 aa)
ihfAUnannotated protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa)
BTO12_00230Unannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
BTO12_24640Unannotated protein. (196 aa)
rplYUnannotated protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (92 aa)
GCA_001558055_02065Unannotated protein. (319 aa)
BTO12_23860Unannotated protein. (88 aa)
BTO12_23850Unannotated protein. (449 aa)
ihfBUnannotated protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa)
BTO12_23785Unannotated protein; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (556 aa)
BTO12_01475Unannotated protein. (474 aa)
BTO12_05365Unannotated protein. (284 aa)
BTO12_04155Unannotated protein. (182 aa)
BTO12_04035Unannotated protein. (196 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (129 aa)
rpsRUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplIUnannotated protein; Binds to the 23S rRNA. (150 aa)
BTO12_10290Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (463 aa)
BTO12_10545Unannotated protein. (612 aa)
rplLUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (164 aa)
rplAUnannotated protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (234 aa)
rplKUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
BTO12_17270Unannotated protein. (324 aa)
BTO12_16015Unannotated protein; Belongs to the DEAD box helicase family. (443 aa)
BTO12_15965Unannotated protein. (559 aa)
BTO12_15700Unannotated protein. (326 aa)
BTO12_15520Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. (181 aa)
BTO12_15485Unannotated protein. (139 aa)
BTO12_15305Unannotated protein; Belongs to the DEAD box helicase family. (401 aa)
BTO12_15255Unannotated protein. (155 aa)
BTO12_15245Unannotated protein. (147 aa)
deaDUnannotated protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (646 aa)
BTO12_14710Unannotated protein. (376 aa)
recOUnannotated protein; Involved in DNA repair and RecF pathway recombination. (242 aa)
rpsPUnannotated protein; Belongs to the bacterial ribosomal protein bS16 family. (82 aa)
BTO12_06630Unannotated protein. (337 aa)
infBUnannotated protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (896 aa)
rpsOUnannotated protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
BTO12_06275Unannotated protein. (562 aa)
BTO12_06200Unannotated protein. (334 aa)
rpmE2Unannotated protein. (86 aa)
rpsBUnannotated protein; Belongs to the universal ribosomal protein uS2 family. (243 aa)
dnaQUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (255 aa)
BTO12_02360Unannotated protein. (160 aa)
BTO12_02365Unannotated protein. (183 aa)
BTO12_02415Unannotated protein. (158 aa)
rpmIUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
BTO12_03895Unannotated protein. (355 aa)
rplQUnannotated protein. (126 aa)
BTO12_07475Unannotated protein. (149 aa)
BTO12_11035Unannotated protein. (118 aa)
nthUnannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
rnfCUnannotated protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (890 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
topBUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (664 aa)
recRUnannotated protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (189 aa)
BTO12_04885Unannotated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa)
hupB_1Unannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
rpsGUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpmEUnannotated protein; Binds the 23S rRNA. (72 aa)
priAUnannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (733 aa)
fisUnannotated protein; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa)
hupAUnannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
rpsUUnannotated protein; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
dnaGUnannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (583 aa)
GCA_001558055_00887Unannotated protein. (417 aa)
rpmAUnannotated protein; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
rplUUnannotated protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
BTO12_20905Unannotated protein. (347 aa)
matPUnannotated protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (151 aa)
cobBUnannotated protein; Belongs to the sirtuin family. Class III subfamily. (244 aa)
Your Current Organism:
Vibrio splendidus
NCBI taxonomy Id: 29497
Other names: ATCC 33125, Beneckea splendida, CECT 8714 [[Vibrio hemicentroti]], CIP 102893, DSM 19640, DSM 26178 [[Vibrio hemicentroti]], IFO 15643, KCTC 32085 [[Vibrio hemicentroti]], LMG 19031, LMG 4042, LMG:19031, LMG:4042, NBRC 15643, NCCB 53037, NCIMB 1, Photobacter splendidum, V. splendidus, Vibrio hemicentroti, Vibrio hemicentroti Kim et al. 2013, Vibrio sp. AlyHP32, strain AlyHP32 [[Vibrio hemicentroti]]
Server load: low (20%) [HD]