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A0A0D2MSA8 A0A0D2MSA8 MCM7 MCM7 A0A0D2P1H2 A0A0D2P1H2 MCM7-2 MCM7-2 A0A0D2PTQ5 A0A0D2PTQ5 A0A0D2Q091 A0A0D2Q091 A0A0D2Q0W2 A0A0D2Q0W2 A0A0D2QDA9 A0A0D2QDA9 A0A0D2QFR9 A0A0D2QFR9 A0A0D2QIB0 A0A0D2QIB0 A0A0D2RGP7 A0A0D2RGP7 A0A0D2RJQ0 A0A0D2RJQ0 A0A0D2RLE0 A0A0D2RLE0 A0A0D2SCN4 A0A0D2SCN4 FEN1 FEN1 A0A0D2SFT5 A0A0D2SFT5 A0A0D2SHQ5 A0A0D2SHQ5 A0A0D2SJE9 A0A0D2SJE9 A0A0D2SR10 A0A0D2SR10 A0A0D2SW26 A0A0D2SW26 A0A0D2T4W1 A0A0D2T4W1 A0A0D2TB09 A0A0D2TB09 A0A0D2TG65 A0A0D2TG65 A0A0D2TH74 A0A0D2TH74 A0A0D2TKM0 A0A0D2TKM0 A0A0D2TPH6 A0A0D2TPH6 A0A0D2TSE3 A0A0D2TSE3 A0A0D2U7B7 A0A0D2U7B7 A0A0D2U9H4 A0A0D2U9H4 A0A0D2UDT8 A0A0D2UDT8 FEN1-2 FEN1-2 A0A0D2V3C3 A0A0D2V3C3 A0A0D2VA09 A0A0D2VA09 A0A0D2VG53 A0A0D2VG53 A0A0D2VHE0 A0A0D2VHE0 A0A0D2VJT6 A0A0D2VJT6 A0A0D2VPF9 A0A0D2VPF9 A0A0D2VRY9 A0A0D2VRY9 A0A0D2W8B2 A0A0D2W8B2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
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Your Input:
A0A0D2MSA8Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (948 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (494 aa)
A0A0D2P1H2DNA ligase. (804 aa)
MCM7-2DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
A0A0D2PTQ5DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (287 aa)
A0A0D2Q091DNA helicase; Belongs to the MCM family. (727 aa)
A0A0D2Q0W2DNA helicase; Belongs to the MCM family. (935 aa)
A0A0D2QDA9Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
A0A0D2QFR9Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
A0A0D2QIB0Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (626 aa)
A0A0D2RGP7DNA helicase; Belongs to the MCM family. (768 aa)
A0A0D2RJQ0DNA helicase; Belongs to the MCM family. (940 aa)
A0A0D2RLE0Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (266 aa)
A0A0D2SCN4DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (623 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (414 aa)
A0A0D2SFT5DNA ligase. (1406 aa)
A0A0D2SHQ5DNA polymerase. (1588 aa)
A0A0D2SJE9DNA ligase. (1211 aa)
A0A0D2SR10FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (662 aa)
A0A0D2SW26Sld5 domain-containing protein. (185 aa)
A0A0D2T4W1Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (856 aa)
A0A0D2TB09FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (647 aa)
A0A0D2TG65DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2204 aa)
A0A0D2TH74Replication factor C subunit 1. (852 aa)
A0A0D2TKM0DNA helicase; Belongs to the MCM family. (758 aa)
A0A0D2TPH6Sld5 domain-containing protein. (200 aa)
A0A0D2TSE3Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (421 aa)
A0A0D2U7B7Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (266 aa)
A0A0D2U9H4DNA primase; Belongs to the eukaryotic-type primase small subunit family. (452 aa)
A0A0D2UDT8DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (530 aa)
FEN1-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa)
A0A0D2V3C3Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (334 aa)
A0A0D2VA09DNA helicase; Belongs to the MCM family. (839 aa)
A0A0D2VG53DNA polymerase. (1097 aa)
A0A0D2VHE0Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (629 aa)
A0A0D2VJT6Sld5 domain-containing protein. (200 aa)
A0A0D2VPF9DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (231 aa)
A0A0D2VRY9DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (209 aa)
A0A0D2W8B2DNA helicase; Belongs to the MCM family. (734 aa)
Your Current Organism:
Gossypium raimondii
NCBI taxonomy Id: 29730
Other names: G. raimondii, Gossypium raimondii Ulbr.
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