(47 nodes) Nervous system development network (Vitis vinifera)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	D7UAZ2_VITVI	Uncharacterized protein. (71 aa)
	E0CQ54_VITVI	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (188 aa)
	E0CTY0_VITVI	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (378 aa)
	D7T187_VITVI	Amidohydro-rel domain-containing protein. (536 aa)
	D7SN66_VITVI	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (1015 aa)
	D7SJV3_VITVI	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1705 aa)
	VITISV_041078	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa)
	VITISV_016247	Uncharacterized protein. (124 aa)
	VITISV_005429	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1704 aa)
	D7SZG4_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (143 aa)
	D7SVM1_VITVI	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (389 aa)
	D7SP01_VITVI	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (172 aa)
	F6GWI3_VITVI	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	F6GV37_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (168 aa)
	F6GTG4_VITVI	Rhodanese domain-containing protein. (426 aa)
	F6GSZ0_VITVI	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (437 aa)
	F6GSP7_VITVI	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (314 aa)
	E0CV38_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (132 aa)
	D7T1N8_VITVI	Protein kinase domain-containing protein. (66 aa)
	D7T4W9_VITVI	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (193 aa)
	D7TCL2_VITVI	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa)
	D7TQ86_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (189 aa)
	D7TSK0_VITVI	Ncstrn_small domain-containing protein. (671 aa)
	D7TU01_VITVI	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (438 aa)
	D7TWJ8_VITVI	Uncharacterized protein. (518 aa)
	D7TYJ1_VITVI	Uncharacterized protein. (72 aa)
	D7UC71_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (256 aa)
	F6I7A3_VITVI	Formin-like protein; Belongs to the formin-like family. (1154 aa)
	F6I5Q2_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (118 aa)
	F6I5E4_VITVI	Amidohydro-rel domain-containing protein. (55 aa)
	F6I4Z4_VITVI	Uncharacterized protein. (74 aa)
	F6I4Y4_VITVI	Uncharacterized protein. (125 aa)
	F6I3H7_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (91 aa)
	F6I110_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (132 aa)
	F6I0E2_VITVI	Uncharacterized protein. (67 aa)
	ADF	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (143 aa)
	F6HTG2_VITVI	Uncharacterized protein. (64 aa)
	F6HTG1_VITVI	Uncharacterized protein. (53 aa)
	F6HQ43_VITVI	Endo/exonuclease/phosphatase domain-containing protein. (511 aa)
	F6HN87_VITVI	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (139 aa)
	F6HMV3_VITVI	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	F6HIZ5_VITVI	Uncharacterized protein. (99 aa)
	F6HDJ5_VITVI	Endo/exonuclease/phosphatase domain-containing protein. (442 aa)
	F6HCN1_VITVI	Uncharacterized protein. (116 aa)
	F6HBZ4_VITVI	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	F6H4R6_VITVI	Uncharacterized protein. (307 aa)
	F6GXI4_VITVI	Uncharacterized protein. (296 aa)

Your Current Organism:

Vitis vinifera

NCBI taxonomy Id: 29760
Other names: V. vinifera, Vitis vinifera L., Vitis vinifera subsp. vinifera, wine grape

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADF	D7SVM1_VITVI	F6HZJ8	D7SVM1	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.455
D7SJV3_VITVI	D7SN66_VITVI	D7SJV3	D7SN66	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	0.909
D7SJV3_VITVI	D7SP01_VITVI	D7SJV3	D7SP01	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.744
D7SJV3_VITVI	D7TU01_VITVI	D7SJV3	D7TU01	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.711
D7SJV3_VITVI	D7UAZ2_VITVI	D7SJV3	D7UAZ2	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.559
D7SJV3_VITVI	E0CQ54_VITVI	D7SJV3	E0CQ54	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.788
D7SJV3_VITVI	F6GTG4_VITVI	D7SJV3	F6GTG4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Rhodanese domain-containing protein.	0.559
D7SJV3_VITVI	F6GXI4_VITVI	D7SJV3	F6GXI4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.616
D7SJV3_VITVI	F6H4R6_VITVI	D7SJV3	F6H4R6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.557
D7SJV3_VITVI	F6HCN1_VITVI	D7SJV3	F6HCN1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.546
D7SJV3_VITVI	F6HTG1_VITVI	D7SJV3	F6HTG1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.540
D7SJV3_VITVI	F6HTG2_VITVI	D7SJV3	F6HTG2	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.573
D7SJV3_VITVI	F6I4Y4_VITVI	D7SJV3	F6I4Y4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.561
D7SJV3_VITVI	F6I4Z4_VITVI	D7SJV3	F6I4Z4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.559
D7SJV3_VITVI	F6I7A3_VITVI	D7SJV3	F6I7A3	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Formin-like protein; Belongs to the formin-like family.	0.514
D7SJV3_VITVI	VITISV_005429	D7SJV3	A5ACP0	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
D7SN66_VITVI	D7SJV3_VITVI	D7SN66	D7SJV3	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.909
D7SN66_VITVI	D7SP01_VITVI	D7SN66	D7SP01	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.996
D7SN66_VITVI	D7TU01_VITVI	D7SN66	D7TU01	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.994
D7SN66_VITVI	D7UAZ2_VITVI	D7SN66	D7UAZ2	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	Uncharacterized protein.	0.946