STRINGSTRING
KAE1 KAE1 A0A1V6RU90 A0A1V6RU90 A0A1V6RV32 A0A1V6RV32 A0A1V6RV82 A0A1V6RV82 A0A1V6RW39 A0A1V6RW39 A0A1V6RZ27 A0A1V6RZ27 PIF1 PIF1 A0A1V6S085 A0A1V6S085 A0A1V6S2N9 A0A1V6S2N9 A0A1V6S4Y7 A0A1V6S4Y7 A0A1V6S5C6 A0A1V6S5C6 A0A1V6S5F1 A0A1V6S5F1 A0A1V6S6K2 A0A1V6S6K2 A0A1V6S8J0 A0A1V6S8J0 A0A1V6S8R0 A0A1V6S8R0 A0A1V6S8Z3 A0A1V6S8Z3 A0A1V6S9K8 A0A1V6S9K8 A0A1V6SAP2 A0A1V6SAP2 A0A1V6SBX2 A0A1V6SBX2 A0A1V6SAQ4 A0A1V6SAQ4 A0A1V6SBA1 A0A1V6SBA1 A0A1V6SBP4 A0A1V6SBP4 A0A1V6SF62 A0A1V6SF62 A0A1V6SEQ5 A0A1V6SEQ5 A0A1V6SEN0 A0A1V6SEN0 A0A1V6SDG8 A0A1V6SDG8 A0A1V6SC44 A0A1V6SC44 A0A1V6QZK0 A0A1V6QZK0 A0A1V6R257 A0A1V6R257 A0A1V6RCX3 A0A1V6RCX3 A0A1V6RDF8 A0A1V6RDF8 A0A1V6RDP5 A0A1V6RDP5 A0A1V6RHM1 A0A1V6RHM1 A0A1V6RN65 A0A1V6RN65 A0A1V6RS46 A0A1V6RS46 A0A1V6RSL3 A0A1V6RSL3 A0A1V6RSX4 A0A1V6RSX4 A0A1V6RT22 A0A1V6RT22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (364 aa)
A0A1V6RU90ATP-dependent DNA helicase; Belongs to the helicase family. (358 aa)
A0A1V6RV32Uncharacterized protein. (229 aa)
A0A1V6RV82Uncharacterized protein. (1501 aa)
A0A1V6RW39ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (510 aa)
A0A1V6RZ27DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (762 aa)
A0A1V6S085Rif1_N domain-containing protein. (1722 aa)
A0A1V6S2N9DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (620 aa)
A0A1V6S4Y7Uncharacterized protein. (237 aa)
A0A1V6S5C6AAA_23 domain-containing protein. (1297 aa)
A0A1V6S5F1SANT domain-containing protein. (839 aa)
A0A1V6S6K2Uncharacterized protein. (314 aa)
A0A1V6S8J0HTH myb-type domain-containing protein. (852 aa)
A0A1V6S8R0Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1226 aa)
A0A1V6S8Z3HTH APSES-type domain-containing protein. (447 aa)
A0A1V6S9K8Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2894 aa)
A0A1V6SAP2Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (299 aa)
A0A1V6SBX2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2474 aa)
A0A1V6SAQ4ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (712 aa)
A0A1V6SBA1CUE domain-containing protein. (877 aa)
A0A1V6SBP4Uncharacterized protein. (125 aa)
A0A1V6SF62Uncharacterized protein. (1658 aa)
A0A1V6SEQ5Uncharacterized protein. (397 aa)
A0A1V6SEN0SAP domain-containing protein. (653 aa)
A0A1V6SDG8Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
A0A1V6SC44Uncharacterized protein. (738 aa)
A0A1V6QZK0Uncharacterized protein. (273 aa)
A0A1V6R257Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
A0A1V6RCX3Telomere_reg-2 domain-containing protein. (1007 aa)
A0A1V6RDF8Uncharacterized protein. (1566 aa)
A0A1V6RDP5DRMBL domain-containing protein. (844 aa)
A0A1V6RHM1Uncharacterized protein. (255 aa)
A0A1V6RN65Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (781 aa)
A0A1V6RS46HD domain-containing protein. (235 aa)
A0A1V6RSL3Checkpoint protein; Belongs to the HUS1 family. (343 aa)
A0A1V6RSX4Telo_bind domain-containing protein. (602 aa)
A0A1V6RT22Uncharacterized protein. (261 aa)
Your Current Organism:
Penicillium vulpinum
NCBI taxonomy Id: 29845
Other names: P. vulpinum, Penicillium claviforme
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.