STRINGSTRING
FEN1 FEN1 SLX1 SLX1 A0A1V6RN37 A0A1V6RN37 A0A1V6RN65 A0A1V6RN65 SLX4 SLX4 A0A1V6S0V8 A0A1V6S0V8 A0A1V6S331 A0A1V6S331 A0A1V6S6K3 A0A1V6S6K3 A0A1V6S920 A0A1V6S920 A0A1V6SAH1 A0A1V6SAH1 A0A1V6SG70 A0A1V6SG70
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (401 aa)
A0A1V6RN37Endonuclease. (326 aa)
A0A1V6RN65Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (781 aa)
SLX4Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (881 aa)
A0A1V6S0V8Uncharacterized protein. (874 aa)
A0A1V6S331Uncharacterized protein. (1128 aa)
A0A1V6S6K3Uncharacterized protein. (734 aa)
A0A1V6S920Uncharacterized protein. (750 aa)
A0A1V6SAH1ERCC4 domain-containing protein. (589 aa)
A0A1V6SG70Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (763 aa)
Your Current Organism:
Penicillium vulpinum
NCBI taxonomy Id: 29845
Other names: P. vulpinum, Penicillium claviforme
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