STRINGSTRING
A0A1V6S6D5 A0A1V6S6D5 A0A1V6RHC9 A0A1V6RHC9 A0A1V6RGG9 A0A1V6RGG9 A0A1V6SFS2 A0A1V6SFS2 A0A1V6RG81 A0A1V6RG81 FEN1 FEN1 A0A1V6RDJ6 A0A1V6RDJ6 MCM7 MCM7 A0A1V6R257 A0A1V6R257 A0A1V6S5N5 A0A1V6S5N5 A0A1V6RHF1 A0A1V6RHF1 A0A1V6S795 A0A1V6S795 A0A1V6S5K3 A0A1V6S5K3 A0A1V6S850 A0A1V6S850 A0A1V6S4S6 A0A1V6S4S6 A0A1V6SCK9 A0A1V6SCK9 A0A1V6S356 A0A1V6S356 A0A1V6RWJ3 A0A1V6RWJ3 A0A1V6RUW9 A0A1V6RUW9 A0A1V6RSP1 A0A1V6RSP1 A0A1V6S8X9 A0A1V6S8X9 A0A1V6SCE3 A0A1V6SCE3 A0A1V6SBK3 A0A1V6SBK3 A0A1V6SBH6 A0A1V6SBH6 A0A1V6RSJ4 A0A1V6RSJ4 A0A1V6RRP0 A0A1V6RRP0
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1V6S6D5DNA primase; Belongs to the eukaryotic-type primase small subunit family. (503 aa)
A0A1V6RHC9DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (271 aa)
A0A1V6RGG9DNA helicase; Belongs to the MCM family. (954 aa)
A0A1V6SFS2FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (588 aa)
A0A1V6RG81Replication factor C subunit 1. (1055 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
A0A1V6RDJ6DNA helicase; Belongs to the MCM family. (896 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
A0A1V6R257Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
A0A1V6S5N5DNA polymerase. (1700 aa)
A0A1V6RHF1DNA helicase; Belongs to the MCM family. (719 aa)
A0A1V6S795Sld5 domain-containing protein. (229 aa)
A0A1V6S5K3DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (271 aa)
A0A1V6S850DNA ligase. (999 aa)
A0A1V6S4S6Sld5 domain-containing protein. (178 aa)
A0A1V6SCK9DNA helicase; Belongs to the MCM family. (1001 aa)
A0A1V6S356Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (858 aa)
A0A1V6RWJ3DNA ligase. (821 aa)
A0A1V6RUW9Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (786 aa)
A0A1V6RSP1DNA polymerase. (1461 aa)
A0A1V6S8X9DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (656 aa)
A0A1V6SCE3Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (867 aa)
A0A1V6SBK3DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2227 aa)
A0A1V6SBH6DNA helicase; Belongs to the MCM family. (877 aa)
A0A1V6RSJ4DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
A0A1V6RRP0DNA polymerase. (1104 aa)
Your Current Organism:
Penicillium vulpinum
NCBI taxonomy Id: 29845
Other names: P. vulpinum, Penicillium claviforme
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