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ABW09600.1 ABW09600.1 ABW09760.1 ABW09760.1 hisG hisG lysA lysA ABW10122.1 ABW10122.1 ABW10328.1 ABW10328.1 ABW10329.1 ABW10329.1 ABW10330.1 ABW10330.1 ABW10359.1 ABW10359.1 ABW10411.1 ABW10411.1 aroA aroA dapB dapB dapA dapA dapF dapF ABW11033.1 ABW11033.1 aroQ aroQ ABW11101.1 ABW11101.1 ABW11102.1 ABW11102.1 ABW11135.1 ABW11135.1 aroC aroC aroK aroK aroB aroB argC argC argJ argJ argB argB argD argD argF argF argR argR argG argG argH argH ABW11183.1 ABW11183.1 trpD trpD ABW11271.1 ABW11271.1 hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI trpE trpE trpC trpC trpB trpB trpA trpA ABW11425.1 ABW11425.1 ABW11860.1 ABW11860.1 dapB-2 dapB-2 ABW13018.1 ABW13018.1 ABW13270.1 ABW13270.1 argJ-2 argJ-2 ABW14420.1 ABW14420.1 ABW14517.1 ABW14517.1 proA proA proB proB ABW15230.1 ABW15230.1 ABW15408.1 ABW15408.1 proC proC ABW15910.1 ABW15910.1 asd asd ABW16314.1 ABW16314.1 aroE aroE ABW16388.1 ABW16388.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ABW09600.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: fal:FRAAL6756 aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex. (216 aa)
ABW09760.1PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: fal:FRAAL6591 phosphoribosyl-ATP pyrophosphatase (PRA-PH); Belongs to the PRA-PH family. (149 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (437 aa)
ABW10122.1PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: fal:FRAAL6420 putative diaminopimelate decarboxylase protein. (453 aa)
ABW10328.1PFAM: aminotransferase class I and II; KEGG: fal:FRAAL6125 N-succinyl-L,L-diaminopimelate aminotransferase. (618 aa)
ABW10329.1KEGG: fal:FRAAL6124 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (293 aa)
ABW10330.1TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: fal:FRAAL6123 succinyl-diaminopimelate desuccinylase (SDAP). (376 aa)
ABW10359.1KEGG: fal:FRAAL6068 hypothetical protein; putative chorismate mutase. (119 aa)
ABW10411.1TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase; KEGG: fal:FRAAL6017 putative inositol monophosphatase; putative signal peptide. (280 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (459 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (247 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (307 aa)
ABW11033.1PFAM: prephenate dehydratase; KEGG: fal:FRAAL3225 prephenate dehydratase (PDT). (317 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
ABW11101.1PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fal:FRAAL0918 aminoquinate/shkimate dehydrogenase. (291 aa)
ABW11102.1PFAM: 3-dehydroquinate synthase; KEGG: fal:FRAAL0919 dehydroquinate synthase. (364 aa)
ABW11135.1PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: fal:FRAAL5249 shikimate 5-dehydrogenase. (298 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (371 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (360 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (390 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (344 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: fal:FRAAL5205 acetylornithine transaminase (NAcOATase and DapATase), PLP-dependent; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (414 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (317 aa)
argRArginine repressor, ArgR; Regulates arginine biosynthesis genes. (189 aa)
argGPFAM: argininosuccinate synthase; KEGG: fal:FRAAL5202 argininosuccinate synthase (citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: fal:FRAAL5201 argininosuccinate lyase. (511 aa)
ABW11183.1TIGRFAM: DNA-3-methyladenine glycosylase; PFAM: methylpurine-DNA glycosylase (MPG); KEGG: fal:FRAAL5200 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (224 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (432 aa)
ABW11271.1KEGG: fal:FRAAL5083 phospho-2-dehydro-3-deoxyheptonate aldolase (phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase); TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II. (452 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: fal:FRAAL5003 histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (453 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: fal:FRAAL5002 imidazoleglycerol-phosphate dehydratase. (195 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa)
hisABifunctional HisA/TrpF protein; KEGG: fal:FRAAL4977 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase, N-(5'-phosphoribosyl)anthranilate isomerase; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. (245 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (248 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (169 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (525 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: fal:FRAAL4969 indole-3-glycerol phosphate synthase 1 (IGPS 1); Belongs to the TrpC family. (268 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (490 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (306 aa)
ABW11425.1PFAM: prephenate dehydratase; KEGG: fal:FRAAL4901 prephenate dehydratase. (287 aa)
ABW11860.1PFAM: Proline dehydrogenase; KEGG: fal:FRAAL4348 putative proline dehydrogenase (proline dehydrogenase family protein). (360 aa)
dapB-2Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (248 aa)
ABW13018.1PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; KEGG: pau:PA14_09440 phenazine biosynthesis protein PhzE. (685 aa)
ABW13270.1PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; KEGG: stp:Strop_2960 glutamine amidotransferase class-I. (657 aa)
argJ-2Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
ABW14420.1Prephenate dehydrogenase; PFAM: amino acid-binding ACT domain protein; Prephenate dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: fal:FRAAL2252 putative prephenate dehydrogenase. (396 aa)
ABW14517.1PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: fal:FRAAL2126 anthranilate synthase. (398 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa)
ABW15230.1KEGG: fal:FRAAL1247 putative acetyltransferase. (224 aa)
ABW15408.1Aminotransferase class I and II; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: fal:FRAAL1062 aspartate aminotransferase (transaminase A) (ASPAT). (402 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (297 aa)
ABW15910.1TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: fal:FRAAL0605 aspartokinase (aspartate kinase) [contains: aspartokinase alpha subunit (ASK-alpha); aspartokinase beta subunit (ASK-beta)]; Belongs to the aspartokinase family. (422 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa)
ABW16314.1KEGG: sen:SACE_6492 inositol-phosphate phosphatase. (175 aa)
aroEShikimate dehydrogenase substrate binding domain protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
ABW16388.1PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: stm:STM3859 shikimate 5-dehydrogenase. (272 aa)
Your Current Organism:
Frankia sp. EAN1pec
NCBI taxonomy Id: 298653
Other names: F. sp. EAN1pec
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