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ABW10524.1 ABW10524.1 ABW09596.1 ABW09596.1 ABW10112.1 ABW10112.1 ABW10241.1 ABW10241.1 mshB mshB ABW10378.1 ABW10378.1 bioB bioB bioD bioD ABW10425.1 ABW10425.1 thiL thiL ABW10449.1 ABW10449.1 ABW10461.1 ABW10461.1 ABW10537.1 ABW10537.1 ABW10581.1 ABW10581.1 ackA ackA ABW10692.1 ABW10692.1 ABW11036.1 ABW11036.1 ABW11081.1 ABW11081.1 metK metK lipA lipA thiG thiG ABW11279.1 ABW11279.1 thiE thiE ABW11931.1 ABW11931.1 ABW12642.1 ABW12642.1 ABW12719.1 ABW12719.1 lipA-2 lipA-2 ABW12901.1 ABW12901.1 ABW12903.1 ABW12903.1 metE metE ABW12967.1 ABW12967.1 accD accD folD folD bioA bioA cysC cysC cysD cysD metXA metXA ABW14089.1 ABW14089.1 ABW14190.1 ABW14190.1 mshC mshC ABW14387.1 ABW14387.1 ABW14394.1 ABW14394.1 ABW14416.1 ABW14416.1 ABW14484.1 ABW14484.1 cysC-2 cysC-2 dxs dxs thiC thiC ABW15003.1 ABW15003.1 ABW15004.1 ABW15004.1 ABW15005.1 ABW15005.1 ABW15042.1 ABW15042.1 ispH-2 ispH-2 ABW15326.1 ABW15326.1 mshA mshA mshD mshD cysC-3 cysC-3 cysD-2 cysD-2 ABW15761.1 ABW15761.1 ABW15762.1 ABW15762.1 ABW15766.1 ABW15766.1 ABW15804.1 ABW15804.1 asd asd ABW16521.1 ABW16521.1 ABW16586.1 ABW16586.1 egtA egtA egtB egtB egtC egtC egtD egtD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ABW10524.1TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL5886 acetyl-CoA synthetase, has propionyl-CoA synthetase activity. (673 aa)
ABW09596.1KEGG: ace:Acel_1868 LmbE family protein. (148 aa)
ABW10112.1Cysteine--tRNA ligase; PFAM: Cysteinyl-tRNA synthetase class Ia; KEGG: ace:Acel_1446 cysteine--tRNA ligase. (371 aa)
ABW10241.1PFAM: LmbE family protein; KEGG: bra:BRADO4834 conserved hypothetical protein; putative deacetylase. (217 aa)
mshBLmbE family protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (305 aa)
ABW10378.1PFAM: UBA/THIF-type NAD/FAD binding protein; Rhodanese domain protein; MoeZ/MoeB domain protein; KEGG: fal:FRAAL6050 molybdopterin-synthase sulfurylase; probable adenylation/thiocarboxylation of MoaD C-terminus; (zinc-containing enyzyme). (390 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (361 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa)
ABW10425.18-amino-7-oxononanoate synthase; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: fal:FRAAL6001 8-amino-7-oxononanoate synthase. (418 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (375 aa)
ABW10449.1PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: fal:FRAAL5974 hypothetical protein; putative membrane protein; putative glycine C-acetyltransferase. (492 aa)
ABW10461.1PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: fal:FRAAL5951 homoserine dehydrogenase (HDH). (439 aa)
ABW10537.1PFAM: Methionine synthase vitamin-B12 independent; KEGG: fal:FRAAL5860 hypothetical protein. (372 aa)
ABW10581.1TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: fal:FRAAL5819 bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase). (273 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (381 aa)
ABW10692.1PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL5696 acetoacetyl-CoA synthetase (acyl-activating enzyme 1). (568 aa)
ABW11036.1Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: fal:FRAAL3228 putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit. (420 aa)
ABW11081.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1262 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (398 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (328 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (303 aa)
ABW11279.1TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: fal:FRAAL5076 thiamine biosynthesis protein ThiS. (95 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (229 aa)
ABW11931.1Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: fal:FRAAL4280 putative branched-chain alpha-keto acid dehydrogenase E1-alpha subunit. (358 aa)
ABW12642.1PFAM: AMP-dependent synthetase and ligase; KEGG: nfa:nfa41510 putative acyl-CoA synthetase. (530 aa)
ABW12719.1Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: mav:MAV_2947 dehydrogenase E1 component superfamily protein. (332 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (308 aa)
ABW12901.1KEGG: sma:SAV2046 putative methionine synthase. (54 aa)
ABW12903.1KEGG: bpd:BURPS668_0791 biotin carboxylase. (159 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (766 aa)
ABW12967.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: fal:FRAAL1468 conserved hypothetical protein; putative glyoxalase/bleomycin resistance domains. (135 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity). In the N-terminal section; belongs to the AccD/PCCB family. (614 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (275 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (428 aa)
cysCSulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (647 aa)
cysDTIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: nfa:nfa33930 putative ATP sulfurylase small subunit. (311 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (414 aa)
ABW14089.1Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: mav:MAV_2947 dehydrogenase E1 component superfamily protein. (332 aa)
ABW14190.1PFAM: NUDIX hydrolase; purine or other phosphorylase family 1; KEGG: fal:FRAAL3911 conserved hypothetical protein; putative phosphorylase and reductase domains. (662 aa)
mshCCysteine--tRNA ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (444 aa)
ABW14387.1KEGG: sma:SAV247 hypothetical protein. (128 aa)
ABW14394.1PFAM: TENA/THI-4 domain protein; KEGG: pab:PAB1642 transcriptional regulator. (207 aa)
ABW14416.1KEGG: fal:FRAAL1834 hypothetical protein; putative membrane protein. (184 aa)
ABW14484.1KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa)
cysC-2Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (606 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (650 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (606 aa)
ABW15003.1TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: fal:FRAAL1500 cysteine synthase B (O-acetylserine sulfhydrolase B). (315 aa)
ABW15004.1PFAM: thiamineS protein; KEGG: fal:FRAAL1499 putative MoaD-like protein (molybdopterin (MPT) synthase, small subunit; chlorate resistance). (142 aa)
ABW15005.1PFAM: Mov34/MPN/PAD-1 family protein; KEGG: tfu:Tfu_2370 Mov34/MPN/PAD-1. (148 aa)
ABW15042.1PFAM: NMT1/THI5 like domain protein; KEGG: fal:FRAAL1450 conserved hypothetical protein; putative ABC transporter substrate-binding protein. (360 aa)
ispH-2Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (657 aa)
ABW15326.1PFAM: carboxyl transferase; KEGG: fal:FRAAL1154 putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain). (526 aa)
mshAGlycosyl transferase group 1; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (434 aa)
mshDGCN5-related N-acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (322 aa)
cysC-3Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (640 aa)
cysD-2TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: nfa:nfa33930 putative ATP sulfurylase small subunit. (319 aa)
ABW15761.1TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: fal:FRAAL0784 cysteine synthase B, O-acetylserine sulfhydrylase B. (463 aa)
ABW15762.1Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: fal:FRAAL0783 cystathionine gamma-synthase, PLP-dependent. (385 aa)
ABW15766.1PFAM: transferase hexapeptide repeat containing protein; KEGG: fal:FRAAL6257 putative serine O-acetyltransferase. (191 aa)
ABW15804.1PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL0381 acetyl-CoA synthetase of the propionate catabolism operon with firefly luciferase-like ATPase domain. (627 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa)
ABW16521.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: rha:RHA1_ro06019 hypothetical protein. (143 aa)
ABW16586.1PFAM: dehydrogenase E1 component; KEGG: fal:FRAAL0071 pyruvate dehydrogenase E1 component, alpha subunit. (359 aa)
egtAGlutamate--cysteine ligase GCS2; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (472 aa)
egtBProtein of unknown function DUF323; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (506 aa)
egtCConserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (247 aa)
egtDConserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (399 aa)
Your Current Organism:
Frankia sp. EAN1pec
NCBI taxonomy Id: 298653
Other names: F. sp. EAN1pec
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