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ABW09684.1 ABW09684.1 eno eno ABW10307.1 ABW10307.1 glyA glyA ABW10524.1 ABW10524.1 ABW10549.1 ABW10549.1 fbiD fbiD ackA ackA ABW11012.1 ABW11012.1 pfp pfp ABW11513.1 ABW11513.1 pfkA pfkA glyA-2 glyA-2 ABW12009.1 ABW12009.1 ABW12642.1 ABW12642.1 gpmA gpmA ABW14144.1 ABW14144.1 ABW14700.1 ABW14700.1 ABW15211.1 ABW15211.1 ABW15214.1 ABW15214.1 ABW15215.1 ABW15215.1 mdh mdh gpmA-2 gpmA-2 ABW15853.1 ABW15853.1 ppc ppc ABW16175.1 ABW16175.1 ABW16275.1 ABW16275.1 serC serC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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ABW09684.1Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
ABW10307.1TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: fal:FRAAL6145 fructose 1,6-bisphosphatase II. (353 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
ABW10524.1TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL5886 acetyl-CoA synthetase, has propionyl-CoA synthetase activity. (673 aa)
ABW10549.1KEGG: fal:FRAAL5848 D-3-phosphoglycerate dehydrogenase (PgdH); TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (529 aa)
fbiDConserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (259 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (381 aa)
ABW11012.1PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: tfu:Tfu_3025 putative alcohol dehydrogenase. (377 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)
ABW11513.1KEGG: fal:FRAAL3693 putative lipoprotein; Belongs to the ComB family. (276 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (445 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
ABW12009.1Hypothetical protein. (127 aa)
ABW12642.1PFAM: AMP-dependent synthetase and ligase; KEGG: nfa:nfa41510 putative acyl-CoA synthetase. (530 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (244 aa)
ABW14144.1KEGG: msm:MSMEG_3445 5,10-methylenetetrahydromethanopterin reductase. (335 aa)
ABW14700.1Hypothetical protein; KEGG: rrs:RoseRS_0245 phosphoglycerate mutase. (158 aa)
ABW15211.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: fal:FRAAL1263 conserved hypothetical protein; putative SAM domain. (944 aa)
ABW15214.1TIGRFAM: LPPG domain containing protein; PFAM: protein of unknown function UPF0052 and CofD; KEGG: fal:FRAAL1260 hypothetical protein. (360 aa)
ABW15215.1TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: nitroreductase; protein of unknown function DUF129; KEGG: fal:FRAAL1259 putative oxidoreductase. (526 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (310 aa)
gpmA-2Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa)
ABW15853.1KEGG: fal:FRAAL0660 putative formate dehydrogenase. (225 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (981 aa)
ABW16175.1PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: fal:FRAAL5467 putative alcohol dehydrogenase class III. (358 aa)
ABW16275.1Pyruvate phosphate dikinase PEP/pyruvate-binding; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (810 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (374 aa)
Your Current Organism:
Frankia sp. EAN1pec
NCBI taxonomy Id: 298653
Other names: F. sp. EAN1pec
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