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| | DA2_0107 | Acetolactate synthase, large subunit, biosynthetic type. (562 aa) |
| | DA2_1658 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa) |
| | gpmA | Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (249 aa) |
| | DA2_1786 | Saccharopine dehydrogenase family protein. (396 aa) |
| | DA2_1803 | HMGL-like family protein. (609 aa) |
| | DA2_1820 | cys/Met metabolism PLP-dependent enzyme family protein. (400 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | DA2_1976 | Glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein. (192 aa) |
| | DA2_1977 | Chorismate binding enzyme family protein. (518 aa) |
| | DA2_1978 | Prephenate dehydrogenase family protein. (266 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (450 aa) |
| | DA2_1980 | Chorismate mutase type II family protein. (406 aa) |
| | griI | 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (257 aa) |
| | DA2_2009 | Transketolase, C-terminal domain protein. (641 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa) |
| | DA2_2018 | Histidine biosynthesis family protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (657 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | leuD | Isopropylmalate/citramalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa) |
| | DA2_2082 | Enolase, N-terminal domain protein. (236 aa) |
| | patB | Cystathionine beta-lyase patB. (404 aa) |
| | asnB | Asparagine synthase. (605 aa) |
| | DA2_2159 | ilvN domain protein. (125 aa) |
| | DA2_2160 | Acetolactate synthase, large subunit, biosynthetic type. (613 aa) |
| | DA2_2185 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein. (301 aa) |
| | DA2_2198 | Hypothetical protein. (414 aa) |
| | DA2_2210 | Aminoglycoside phosphotransferase. (421 aa) |
| | thrC | Threonine synthase. (472 aa) |
| | DA2_2257 | Shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (288 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (293 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase family protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (133 aa) |
| | DA2_2297 | Aminotransferase class IV family protein. (327 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (546 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (776 aa) |
| | glnA | Glutamine synthetase, type I. (447 aa) |
| | DA2_2437 | GIY-YIG catalytic domain protein. (112 aa) |
| | aspC | Aspartate aminotransferase. (390 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (443 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisH-2 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | DA2_2819 | Aminotransferase class IV family protein. (313 aa) |
| | DA2_2826 | 4Fe-4S binding domain protein; Belongs to the glutamate synthase family. (544 aa) |
| | maf | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (232 aa) |
| | DA2_3045 | HMGL-like family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (440 aa) |
| | DA2_3058 | Acetolactate synthase, small subunit. (156 aa) |
| | DA2_3099 | Serine acetyltransferase. (317 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | DA2_3118 | Conserved region in glutamate synthase family protein. (544 aa) |
| | DA2_3199 | Phage prohead protease, HK97 family. (233 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (416 aa) |
| | DA2_3412 | Aminotransferase class I and II family protein. (394 aa) |
| | DA2_3414 | 5-enolpyruvylshikimate-3-phosphate synthase-like protein. (629 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | DA2_3558 | Aconitate hydratase, putative. (641 aa) |
| | DA2_3606 | Aminoglycoside phosphotransferase. (363 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | DA2_3668 | fxsA cytoplasmic membrane family protein. (273 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (243 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase family protein. (196 aa) |
| | argD | Acetylornithine and succinylornithine aminotransferases family protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | DA2_3838 | Serine dehydratase alpha chain family protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa) |
| | DA2_3840 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (327 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase, class II. (307 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (300 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | argH | Argininosuccinate lyase. (460 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | DA2_1092 | Shikimate kinase family protein. (160 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (453 aa) |
| | trpF | N-(5'phosphoribosyl)anthranilate (PRA) isomerase family protein; Belongs to the TrpF family. (256 aa) |
| | DA2_1059 | Histidinol phosphate phosphatase HisJ family protein; Belongs to the PHP hydrolase family. HisK subfamily. (274 aa) |
| | gltA | Glutamate synthase (NADPH), homotetrameric. (481 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (384 aa) |
| | ahdIC | C.AhdI domain protein. (106 aa) |
| | pfk6 | 6-phosphofructokinase 6; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (448 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (410 aa) |
| | ltaE | Low specificity L-threonine aldolase. (341 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa) |
| | DA2_0615 | Peptidase M20/M25/M40 family protein. (413 aa) |
| | xsc | Sulfoacetaldehyde acetyltransferase; Belongs to the TPP enzyme family. (580 aa) |
| | DA2_0559 | Ribosomal RNA adenine dimethylase family protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (228 aa) |
| | DA2_1858 | Glutamine synthetase, catalytic domain protein. (726 aa) |
| | DA2_1918 | Phosphoglycerate mutase family protein. (402 aa) |
| | DA2_1920 | Acetyltransferase family protein. (309 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (350 aa) |
| | icd | Isocitrate dehydrogenase, NADP-dependent. (382 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF-2 | N-(5'phosphoribosyl)anthranilate (PRA) isomerase family protein; Belongs to the TrpF family. (227 aa) |
| | tthHB8IM | Indole-3-glycerol phosphate synthase domain protein; Belongs to the TrpC family. (275 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | DA2_1147 | Peptidase, M20/M25/M40 family. (439 aa) |
| | DA2_1337 | Diaminopimelate epimerase-like protein. (335 aa) |
| | DA2_1528 | PHP domain protein. (219 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (396 aa) |
| | rex | Redox-sensing transcriptional repressor rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (215 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (353 aa) |
| | aroL | Shikimate kinase 2; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa) |
| | DA2_1623 | Aminotransferase class I and II family protein. (394 aa) |
| | DA2_1624 | Homoserine dehydrogenase, NAD binding domain protein. (166 aa) |
| | DA2_1625 | Homoserine dehydrogenase. (269 aa) |
| | DA2_1627 | Metalloenzyme superfamily protein. (425 aa) |
| | rsmA | Ribosomal RNA small subunit methyltransferase A domain protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (108 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | rpiB | Ribose 5-phosphate isomerase B. (150 aa) |
| | DA2_0528 | Homocysteine S-methyltransferase family protein. (626 aa) |
| | DA2_0527 | B12 binding domain protein. (189 aa) |
| | DA2_0525 | Acetyltransferase family protein; Belongs to the acetyltransferase family. (155 aa) |
| | DA2_0503 | Dihydrodipicolinate reductase, family protein; Belongs to the DapB family. (140 aa) |
| | DA2_0502 | Dihydrodipicolinate reductase, family protein. (119 aa) |
| | DA2_0499 | ACT domain protein. (143 aa) |
| | DA2_0497 | Pyridine nucleotide-disulfide oxidoreductase family protein. (363 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (552 aa) |
| | DA2_0468 | Biotin-requiring enzyme family protein. (1234 aa) |
| | aroQ | Dehydroquinase class II family protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (160 aa) |
| | talC | Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (389 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (321 aa) |
| | DA2_0297 | Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (409 aa) |
| | DA2_0296 | leuA allosteric domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (540 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | DA2_0108 | Acetolactate synthase, small subunit. (163 aa) |
