(51 nodes) DNA replication network (Temnothorax longispinosus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	DBV15_03498	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (2643 aa)
	DBV15_10270	DNA helicase; Belongs to the MCM family. (623 aa)
	DBV15_04628	Ribonuclease h2 subunit c-like protein. (131 aa)
	DBV15_12214	CBFD_NFYB_HMF domain-containing protein. (125 aa)
	DBV15_11201	DNA helicase. (139 aa)
	DBV15_09164	Ras association domain-containing protein 8. (918 aa)
	DBV15_04705	General transcription factor 3C polypeptide 6. (196 aa)
	DBV15_03038	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (1063 aa)
	DBV15_07049	DNA helicase; Belongs to the MCM family. (898 aa)
	DBV15_05490	Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (2931 aa)
	DBV15_09919	Flap endonuclease GEN. (751 aa)
	DBV15_03664	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
	DBV15_00217	AAA domain-containing protein. (1893 aa)
	DBV15_03479	Ribonuclease H2 subunit B. (333 aa)
	DBV15_00232	DNA primase large subunit. (514 aa)
	DBV15_02693	DNA helicase. (838 aa)
	DBV15_06549	DNA helicase; Belongs to the MCM family. (732 aa)
	DBV15_10805	Uncharacterized protein. (351 aa)
	DBV15_03642	Replication protein A subunit. (116 aa)
	DBV15_07359	Uncharacterized protein. (353 aa)
	DBV15_04490	Spindle assembly abnormal protein 6-like protein. (673 aa)
	DBV15_11259	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa)
	DBV15_07994	ATPase WRNIP1. (585 aa)
	DBV15_07992	ATPase WRNIP1. (171 aa)
	DBV15_11391	Dna polymerase epsilon subunit 3-like protein. (130 aa)
	DBV15_09955	Uncharacterized protein. (472 aa)
	DBV15_02036	Uncharacterized protein. (412 aa)
	DBV15_05947	DNA polymerase delta small subunit. (379 aa)
	DBV15_09960	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (624 aa)
	DBV15_11868	Replication protein A subunit. (473 aa)
	DBV15_09303	Replication factor C subunit 4. (391 aa)
	DBV15_12602	DNA helicase. (252 aa)
	DBV15_03134	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (569 aa)
	DBV15_11291	DNA2-like helicase. (2278 aa)
	DBV15_11769	Uncharacterized protein. (423 aa)
	DBV15_06232	Macro domain-containing protein. (270 aa)
	DBV15_08407	DNA helicase; Belongs to the MCM family. (1386 aa)
	DBV15_02841	PH domain-containing protein. (710 aa)
	DBV15_01914	DNA polymerase delta subunit 2. (454 aa)
	DBV15_07371	DNA polymerase. (1063 aa)
	DBV15_01410	PRKR-interacting protein 1-like protein. (272 aa)
	DBV15_04887	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
	DBV15_10213	DNA helicase. (251 aa)
	DBV15_02952	Replication factor C subunit 1. (970 aa)
	DBV15_04698	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
	Fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (452 aa)
	DBV15_01414	DNA helicase; Belongs to the MCM family. (623 aa)
	DBV15_11547	Replication factor C subunit 2. (352 aa)
	DBV15_01209	Uncharacterized protein. (517 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (712 aa)
	DBV15_04650	DNA polymerase. (1414 aa)

Your Current Organism:

Temnothorax longispinosus

NCBI taxonomy Id: 300112
Other names: Leptothorax longispinosus, T. longispinosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBV15_00217	DBV15_00232	A0A4S2KEH1	A0A4S2KDY4	AAA domain-containing protein.	DNA primase large subunit.	0.793
DBV15_00217	DBV15_01414	A0A4S2KEH1	A0A4V3SC95	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.792
DBV15_00217	DBV15_01914	A0A4S2KEH1	A0A4S2L2Y1	AAA domain-containing protein.	DNA polymerase delta subunit 2.	0.767
DBV15_00217	DBV15_02036	A0A4S2KEH1	A0A4S2KJ66	AAA domain-containing protein.	Uncharacterized protein.	0.869
DBV15_00217	DBV15_02693	A0A4S2KEH1	A0A4S2KDV2	AAA domain-containing protein.	DNA helicase.	0.683
DBV15_00217	DBV15_02952	A0A4S2KEH1	A0A4V3S7K3	AAA domain-containing protein.	Replication factor C subunit 1.	0.999
DBV15_00217	DBV15_03038	A0A4S2KEH1	A0A4S2KGP5	AAA domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.874
DBV15_00217	DBV15_03134	A0A4S2KEH1	A0A4S2KT57	AAA domain-containing protein.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.807
DBV15_00217	DBV15_03498	A0A4S2KEH1	A0A4S2KU60	AAA domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.998
DBV15_00217	DBV15_03642	A0A4S2KEH1	A0A4S2KBH4	AAA domain-containing protein.	Replication protein A subunit.	0.794
DBV15_00217	DBV15_04490	A0A4S2KEH1	A0A4S2KAS8	AAA domain-containing protein.	Spindle assembly abnormal protein 6-like protein.	0.805
DBV15_00217	DBV15_04650	A0A4S2KEH1	A0A4S2JNN9	AAA domain-containing protein.	DNA polymerase.	0.917
DBV15_00217	DBV15_04887	A0A4S2KEH1	A0A4V3S685	AAA domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.861
DBV15_00217	DBV15_05490	A0A4S2KEH1	A0A4S2KFY2	AAA domain-containing protein.	Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs.	0.873
DBV15_00217	DBV15_05947	A0A4S2KEH1	A0A4S2KJW2	AAA domain-containing protein.	DNA polymerase delta small subunit.	0.767
DBV15_00217	DBV15_06549	A0A4S2KEH1	A0A4S2KBY8	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.945
DBV15_00217	DBV15_07049	A0A4S2KEH1	A0A4S2KGC5	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.848
DBV15_00217	DBV15_07371	A0A4S2KEH1	A0A4S2L452	AAA domain-containing protein.	DNA polymerase.	0.863
DBV15_00217	DBV15_08407	A0A4S2KEH1	A0A4S2L1N9	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.663
DBV15_00217	DBV15_09164	A0A4S2KEH1	A0A4S2K5Z8	AAA domain-containing protein.	Ras association domain-containing protein 8.	0.999