31 items (Drosophila busckii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Dbus_chr3Rg250	Slmb. (504 aa)
	A0A0M3QTU4	Tai. (1873 aa)
	A0A0M3QVN3	Non-specific serine/threonine protein kinase. (941 aa)
	Dbus_chrXg165	Sqh. (174 aa)
	A0A0M4E194	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (737 aa)
	A0A0M4E5S4	Kuz. (918 aa)
	A0A0M4E609	Catsup. (431 aa)
	Dbus_chr3Lg112	Mtl. (192 aa)
	A0A0M4EEW8	Egfr. (780 aa)
	A0A0M4EF83	Cbl. (845 aa)
	Dbus_chr3Lg604	Cbl. (796 aa)
	A0A0M4EKB3	Mbc; Belongs to the DOCK family. (1971 aa)
	Dbus_chrXg1810	Spri. (1679 aa)
	Dbus_chrXg340	Peb. (1632 aa)
	Dbus_chr3Rg372	Puc; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (458 aa)
	Dbus_chr2Lg717	Gli. (952 aa)
	A0A0M4ESF5	Maker571. (285 aa)
	A0A0M4EVQ8	Vir. (1806 aa)
	A0A0M4EVZ3	Slbo. (289 aa)
	A0A0M4EWG2	Lat. (716 aa)
	Dbus_chr3Lg528	Tie. (591 aa)
	Dbus_chr3Rg720	Ttk. (1044 aa)
	A0A0M4F5A4	Pi3K92E; Belongs to the PI3/PI4-kinase family. (1089 aa)
	Dbus_chr2Lg729	Hrb27C. (421 aa)
	Dbus_chr2Rg77	Shg; Cadherins are calcium-dependent cell adhesion proteins. (1524 aa)
	A0A0M5IZH4	Rme-8. (2496 aa)
	Dbus_chr3Rg406	InR. (2083 aa)
	Dbus_chrXg787	Pvf1; Belongs to the PDGF/VEGF growth factor family. (337 aa)
	A0A0M5J965	Aop. (702 aa)
	Dbus_chr2Lg629	Kis. (1935 aa)
	Dbus_chrXg612	Hep. (850 aa)

Your Current Organism:

Drosophila busckii

NCBI taxonomy Id: 30019
Other names: D. busckii

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0M4E194	A0A0M4EEW8	A0A0M4E194	A0A0M4EEW8	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Egfr.	0.852
A0A0M4E194	A0A0M4EF83	A0A0M4E194	A0A0M4EF83	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Cbl.	0.630
A0A0M4E194	Dbus_chr3Lg112	A0A0M4E194	A0A0M4EC54	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Mtl.	0.536
A0A0M4E194	Dbus_chr3Lg604	A0A0M4E194	A0A0M4EI18	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Cbl.	0.630
A0A0M4E5S4	Dbus_chr2Rg77	A0A0M4E5S4	A0A0M5IYZ5	Kuz.	Shg; Cadherins are calcium-dependent cell adhesion proteins.	0.520
A0A0M4EEW8	A0A0M4E194	A0A0M4EEW8	A0A0M4E194	Egfr.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.852
A0A0M4EEW8	A0A0M4EF83	A0A0M4EEW8	A0A0M4EF83	Egfr.	Cbl.	0.984
A0A0M4EEW8	A0A0M4ESF5	A0A0M4EEW8	A0A0M4ESF5	Egfr.	Maker571.	0.991
A0A0M4EEW8	A0A0M4F5A4	A0A0M4EEW8	A0A0M4F5A4	Egfr.	Pi3K92E; Belongs to the PI3/PI4-kinase family.	0.935
A0A0M4EEW8	Dbus_chr2Rg77	A0A0M4EEW8	A0A0M5IYZ5	Egfr.	Shg; Cadherins are calcium-dependent cell adhesion proteins.	0.588
A0A0M4EEW8	Dbus_chr3Lg112	A0A0M4EEW8	A0A0M4EC54	Egfr.	Mtl.	0.656
A0A0M4EEW8	Dbus_chr3Lg528	A0A0M4EEW8	A0A0M4EY53	Egfr.	Tie.	0.725
A0A0M4EEW8	Dbus_chr3Lg604	A0A0M4EEW8	A0A0M4EI18	Egfr.	Cbl.	0.984
A0A0M4EEW8	Dbus_chr3Rg406	A0A0M4EEW8	A0A0M5J4I4	Egfr.	InR.	0.906
A0A0M4EEW8	Dbus_chrXg787	A0A0M4EEW8	A0A0M5JDM5	Egfr.	Pvf1; Belongs to the PDGF/VEGF growth factor family.	0.933
A0A0M4EF83	A0A0M4E194	A0A0M4EF83	A0A0M4E194	Cbl.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.630
A0A0M4EF83	A0A0M4EEW8	A0A0M4EF83	A0A0M4EEW8	Cbl.	Egfr.	0.984
A0A0M4EF83	A0A0M4F5A4	A0A0M4EF83	A0A0M4F5A4	Cbl.	Pi3K92E; Belongs to the PI3/PI4-kinase family.	0.778
A0A0M4EF83	Dbus_chr3Lg112	A0A0M4EF83	A0A0M4EC54	Cbl.	Mtl.	0.555
A0A0M4EF83	Dbus_chr3Lg528	A0A0M4EF83	A0A0M4EY53	Cbl.	Tie.	0.660