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acnB acnB aceE aceE aceF aceF lpdA lpdA gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD yojH yojH SDY_1632 SDY_1632 fumC fumC fumA fumA SDY_1904 SDY_1904 icdA icdA aspC aspC SDY_2486 SDY_2486 SDY_2645 SDY_2645 mdh mdh fumB fumB frdD frdD frdC frdC frdB frdB frdA frdA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acnBAconitate hydrase B; Code: C; COG: COG1049; Belongs to the aconitase/IPM isomerase family. (865 aa)
aceEPyruvate dehydrogenase decarboxylase component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFPyruvate dehydrogenase dihydrolipoyltransacetylase component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (626 aa)
lpdALipoamide dehydrogenase (NADH); Component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; Code: C; COG: COG1249. (474 aa)
gltACitrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family. (427 aa)
sdhCSuccinate dehydrogenase; Cytochrome b556; Code: C; COG: COG2009. (129 aa)
sdhDSuccinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Code: C; COG: COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucA2-oxoglutarate dehydrogenase, decarboxylase component; Code: C; COG: COG0567. (933 aa)
sucB2-oxoglutarate dehydrogenase, dihydrolipoyltranssuccinase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
yojHConserved hypothetical protein; Code: R; COG: COG0579; orf. (548 aa)
SDY_1632Putative aldehyde dehydrogenase; Code: C; COG: COG1012. (470 aa)
fumCFumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
fumAFumarase A; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
SDY_1904Conserved hypothetical protein. (69 aa)
icdAIsocitrate dehydrogenase; Code: C; COG: COG0538. (416 aa)
aspCAspartate aminotransferase; Code: E; COG: COG1448. (396 aa)
SDY_2486Putative aminotransferase; Code: E; COG: COG0436. (405 aa)
SDY_2645Putative multimodular enzyme; Code: C; COG: COG0281. (759 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
fumBFumarase B; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
frdDFumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
frdCFumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBFumarate reductase, anaerobic, iron-sulfur protein subunit; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdAFumarate reductase, anaerobic, flavoprotein subunit; Code: C; COG: COG1053. (602 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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