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yacF yacF yaeH yaeH ybeD ybeD seqA seqA yejM yejM yejL yejL yejK yejK ycbW ycbW fadR fadR hns hns yciS yciS yciM yciM SDY_1490 SDY_1490 cnu cnu prc prc proQ proQ yfbV yfbV SDY_2524 SDY_2524 SDY_2525 SDY_2525 SDY_2541 SDY_2541 stpA stpA syd syd ygfE ygfE yhbM yhbM slyX slyX hupA hupA yjaG yjaG nfi nfi yijC yijC metJ metJ yiiU yiiU yihI yihI yjgD yjgD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yacFConserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa)
yaeHPutative structural protein; Belongs to the UPF0325 family. (128 aa)
ybeDConserved hypothetical protein; Code: S; COG: COG2921; orf; Belongs to the UPF0250 family. (87 aa)
seqANegative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (181 aa)
yejMPutative sulfatase; Code: R; COG: COG3083. (586 aa)
yejLConserved hypothetical protein; Code: S; COG: COG3082; orf; Belongs to the UPF0352 family. (75 aa)
yejKConserved hypothetical protein; Code: R; COG: COG3081; orf. (335 aa)
ycbWConserved hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (192 aa)
fadRNegative regulator for fad regulon, and positive activator of fabA; Multifunctional regulator of fatty acid metabolism. (239 aa)
hnsDNA-binding protein HLP-II; HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916; Belongs to the histone-like protein H-NS family. (137 aa)
yciSConserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (102 aa)
yciMPutative heat shock protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa)
SDY_1490Conserved hypothetical protein; Code: S; COG: COG3139; orf. (105 aa)
cnuConserved hypothetical protein; Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC; Belongs to the Hha/YmoA/Cnu family. (71 aa)
prcCarboxy-terminal protease for penicillin-binding protein 3; Code: M; COG: COG0793; Belongs to the peptidase S41A family. (682 aa)
proQActivator of ProP osmoprotectant transporter; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. (232 aa)
yfbVConserved hypothetical protein; Code: S; COG: COG3092; orf. (151 aa)
SDY_2524Conserved hypothetical protein. (92 aa)
SDY_2525Putative transporting ATPase; Code: S; COG: COG3101. (182 aa)
SDY_2541Conserved hypothetical protein; Code: T; COG: COG2062; orf. (161 aa)
stpAH-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916; Belongs to the histone-like protein H-NS family. (134 aa)
sydSyd; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. (181 aa)
ygfEConserved hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa)
yhbMPutative control proteins; May be involved in cell division. (294 aa)
slyXHost factor for lysis of phiX174 infection; Code: S; COG: COG2900; Belongs to the SlyX family. (72 aa)
hupADNA-binding protein HU-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
yjaGConserved hypothetical protein; Code: S; COG: COG3068; orf. (196 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa)
yijCConserved hypothetical protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (234 aa)
metJRepressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa)
yiiUConserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (81 aa)
yihIConserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (168 aa)
yjgDConserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. (138 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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