14 items (Shigella dysenteriae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	rsuA	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family. (231 aa)
	bcr	Bicyclomycin resistance protein; Transmembrane protein; Code: GEPR; COG: COG0477. (396 aa)
	yciL	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family. (290 aa)
	ymfC	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family. (207 aa)
	nudJ	Putative phosphohydrolase; Code: LR; COG: COG0494; Belongs to the Nudix hydrolase family. NudJ subfamily. (153 aa)
	ycfB	Conserved hypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (383 aa)
	ycfC	Conserved hypothetical protein; Code: R; COG: COG2915; orf. (213 aa)
	ycfD	Conserved hypothetical protein; Code: S; COG: COG2850; orf. (376 aa)
	cmk	Cytidylate kinase; Code: F; COG: COG0283. (227 aa)
	SDY_2706	Conserved hypothetical protein. (78 aa)
	der	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (503 aa)
	yhhF	Conserved hypothetical protein; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (198 aa)
	yhhL	Conserved hypothetical protein; Code: S; COG: COG3776; orf. (89 aa)
	yjbC	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family. (290 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDY_2706	der	SDY_2706	SDY_2707	Conserved hypothetical protein.	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.713
bcr	rsuA	SDY_0897	SDY_0896	Bicyclomycin resistance protein; Transmembrane protein; Code: GEPR; COG: COG0477.	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	0.691
cmk	der	SDY_2348	SDY_2707	Cytidylate kinase; Code: F; COG: COG0283.	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.984
cmk	rsuA	SDY_2348	SDY_0896	Cytidylate kinase; Code: F; COG: COG0283.	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	0.510
cmk	yciL	SDY_2348	SDY_1339	Cytidylate kinase; Code: F; COG: COG0283.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.834
cmk	yjbC	SDY_2348	SDY_4310	Cytidylate kinase; Code: F; COG: COG0283.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.510
cmk	ymfC	SDY_2348	SDY_2017	Cytidylate kinase; Code: F; COG: COG0283.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.575
der	SDY_2706	SDY_2707	SDY_2706	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Conserved hypothetical protein.	0.713
der	cmk	SDY_2707	SDY_2348	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Cytidylate kinase; Code: F; COG: COG0283.	0.984
der	rsuA	SDY_2707	SDY_0896	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	0.670
der	yciL	SDY_2707	SDY_1339	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.824
der	yhhF	SDY_2707	SDY_3616	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Conserved hypothetical protein; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family.	0.518
der	yjbC	SDY_2707	SDY_4310	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.549
der	ymfC	SDY_2707	SDY_2017	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.673
nudJ	ycfB	SDY_2018	SDY_2019	Putative phosphohydrolase; Code: LR; COG: COG0494; Belongs to the Nudix hydrolase family. NudJ subfamily.	Conserved hypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family.	0.795
nudJ	ycfC	SDY_2018	SDY_2020	Putative phosphohydrolase; Code: LR; COG: COG0494; Belongs to the Nudix hydrolase family. NudJ subfamily.	Conserved hypothetical protein; Code: R; COG: COG2915; orf.	0.691
nudJ	ymfC	SDY_2018	SDY_2017	Putative phosphohydrolase; Code: LR; COG: COG0494; Belongs to the Nudix hydrolase family. NudJ subfamily.	Conserved hypothetical protein; Code: J; COG: COG1187; orf; Belongs to the pseudouridine synthase RsuA family.	0.926
rsuA	bcr	SDY_0896	SDY_0897	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	Bicyclomycin resistance protein; Transmembrane protein; Code: GEPR; COG: COG0477.	0.691
rsuA	cmk	SDY_0896	SDY_2348	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	Cytidylate kinase; Code: F; COG: COG0283.	0.510
rsuA	der	SDY_0896	SDY_2707	16S pseudouridylate 516 synthase; Code: J; COG: COG1187; Belongs to the pseudouridine synthase RsuA family.	Putative GTP-binding factor; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.670