(11 nodes) Nickel cation binding network (Shigella dysenteriae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	hyaB	Hydrogenase-1 large subunit; Code: C; COG: COG0374. (568 aa)
	hyfG	Hydrogenase 4 subunit; Code: C; COG: COG3261. (571 aa)
	hybF	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
	hycE	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261. (569 aa)
	nikA	Periplasmic binding protein for nickel; Code: E; COG: COG0747. (524 aa)
	nikD	ATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
	nikE	ATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
	yhhG	Conserved hypothetical protein; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (133 aa)
	hypA	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (116 aa)
	hypB	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378. (290 aa)
	hybC	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hyaB	hybF	SDY_0948	SDY_3082	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.796
hyaB	hypA	SDY_0948	SDY_2923	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.741
hyaB	hypB	SDY_0948	SDY_2924	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.	0.713
hybC	hybF	SDY_3079	SDY_3082	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.959
hybC	hypA	SDY_3079	SDY_2923	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.696
hybC	hypB	SDY_3079	SDY_2924	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.	0.721
hybF	hyaB	SDY_3082	SDY_0948	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	0.796
hybF	hybC	SDY_3082	SDY_3079	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.959
hybF	hycE	SDY_3082	SDY_2918	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.	0.664
hybF	hyfG	SDY_3082	SDY_2676	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase 4 subunit; Code: C; COG: COG3261.	0.661
hybF	hypB	SDY_3082	SDY_2924	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.	0.962
hycE	hybF	SDY_2918	SDY_3082	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.664
hycE	hypA	SDY_2918	SDY_2923	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.666
hycE	hypB	SDY_2918	SDY_2924	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.	0.954
hyfG	hybF	SDY_2676	SDY_3082	Hydrogenase 4 subunit; Code: C; COG: COG3261.	HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.661
hyfG	hypA	SDY_2676	SDY_2923	Hydrogenase 4 subunit; Code: C; COG: COG3261.	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	0.657
hyfG	hypB	SDY_2676	SDY_2924	Hydrogenase 4 subunit; Code: C; COG: COG3261.	Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.	0.953
hypA	hyaB	SDY_2923	SDY_0948	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	0.741
hypA	hybC	SDY_2923	SDY_3079	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.696
hypA	hycE	SDY_2923	SDY_2918	Pleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.	0.666