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| | envZ | Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | hydH | Sensor kinase for HydG hydrogenase 3 activity; Code: T; COG: COG0642. (458 aa) |
| | coaA | Pantothenate kinase; Code: H; COG: COG1072. (316 aa) |
| | thrA | Homoserine dehydrogenase I; Code: E; COG: COG0527; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | yadI | Putative PTS enzyme II B component; Code: G; COG: COG2893. (146 aa) |
| | ribF | Putative regulator; Code: H; COG: COG0196; Belongs to the ribF family. (313 aa) |
| | araB | L-ribulokinase; Code: C; COG: COG1069. (566 aa) |
| | yacE | Putative DNA repair protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | aceE | Pyruvate dehydrogenase decarboxylase component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Pyruvate dehydrogenase dihydrolipoyltransacetylase component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (626 aa) |
| | folK | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Code: H; COG: COG0801. (159 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | aroL | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | gsk | Inosine-guanosine kinase; Code: G; COG: COG0524. (434 aa) |
| | adk | Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | SDY_0507 | Putative sensor kinase; Hexosephosphate transport; Code: T; COG: COG3851. (387 aa) |
| | nagE | PTS system, N-acetylglucosamine-specific enzyme IIABC; Code: G; COG: COG1263. (648 aa) |
| | gpmA | Phosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa) |
| | rcsC | Sensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa) |
| | yojN | Putative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) |
| | yccC | Conserved hypothetical protein; Code: M; COG: COG3206; orf. (726 aa) |
| | pykA | Pyruvate kinase II; Glucose stimulated; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (480 aa) |
| | SDY_1248 | Putative dihydroxyacetone kinase; Code: G; COG: COG2376. (111 aa) |
| | prsA | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | ychB | Conserved hypothetical protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa) |
| | narX | Nitrate/nitrate sensor; Histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850. (598 aa) |
| | tdk | Thymidine kinase; Code: F; COG: COG1435. (205 aa) |
| | SDY_1495 | Putative kinase; Code: G; COG: COG0524. (214 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | SDY_1543 | Kinase fragment; Code: R; COG: COG1823; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (386 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | ydiA | Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (277 aa) |
| | pfkB | 6-phosphofructokinase II; Suppressor of pfkA; Code: G; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. (309 aa) |
| | SDY_1818 | Conserved hypothetical protein; Code: G; COG: COG3001; orf; Belongs to the fructosamine kinase family. (286 aa) |
| | rstB | Sensor histidine protein kinase; RstA regulator; Code: T; COG: COG0642. (433 aa) |
| | pdxY | Pyridoxal kinase 2 / pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (287 aa) |
| | anmK | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa) |
| | pykF | Pyruvate kinase I, fructose stimulated; Formerly F; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (470 aa) |
| | manX | PTS enzyme IIAB, mannose-specific; Code: G; COG: COG2893. (323 aa) |
| | phoQ | Sensor protein PhoQ; Code: T; COG: COG0642. (486 aa) |
| | ycfX | Putative NAGC-like transcriptional regulator; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa) |
| | ycfW | Putative kinase; Code: M; COG: COG4591. (414 aa) |
| | ycfN | Putative beta-glucosidase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | ptsG | PTS system, glucose-specific IIBC component; Code: G; COG: COG1263. (477 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | yceG | Putative thymidylate kinase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa) |
| | yeiI | Putative kinase; Code: G; COG: COG0524. (362 aa) |
| | yehU | Putative 2-component sensor protein; Code: T; COG: COG3275. (561 aa) |
| | baeS | Sensor protein for BaeR; Code: T; COG: COG0642. (467 aa) |
| | gpmB | Phosphoglyceromutase 2; Code: G; COG: COG0406; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | evgS | Putative sensor for regulator EvgA; Code: ET; COG: COG0834. (1197 aa) |
| | ptxA | Putative PTS system enzyme II A component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa) |
| | sgaB | Conserved hypothetical protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (101 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (578 aa) |
| | treB | PTS system enzyme II, trehalose specific; Code: G; COG: COG1263. (473 aa) |
| | yjdH | Putative 2-component sensor protein; Code: T; COG: COG3290. (543 aa) |
| | lysC | Aspartokinase III; Lysine sensitive; Code: E; COG: COG0527; Belongs to the aspartokinase family. (449 aa) |
| | pgi | Glucosephosphate isomerase; Code: G; COG: COG0166; Belongs to the GPI family. (549 aa) |
| | uhpB | Sensor histidine protein kinase phosphorylates UhpA; Code: T; COG: COG3851. (501 aa) |
| | SDY_4133 | Putative kinase; Code: G; COG: COG0524. (333 aa) |
| | SDY_4127 | Putative histidine kinase; Code: T; COG: COG0642. (754 aa) |
| | phnN | ATP-binding component of phosphonate transport; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (185 aa) |
| | basS | Sensor protein for basR; Code: T; COG: COG0642. (363 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | waaP | Putative LPS biosynthesis enzyme; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (268 aa) |
| | yibO | Putative 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (309 aa) |
| | yigR | Conserved hypothetical protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | yihE | Conserved hypothetical protein; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa) |
| | glnL | Histidine protein kinase sensor for GlnG regulator; Nitrogen regulator II, NRII; Code: T; COG: COG3852. (349 aa) |
| | rhaB | Rhamnulokinase; Code: G; COG: COG1070. (387 aa) |
| | cpxA | Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (258 aa) |
| | ptsA | PEP-protein phosphotransferase system enzyme I; Code: G; COG: COG1080; Belongs to the PEP-utilizing enzyme family. (711 aa) |
| | SDY_2192 | Putative chaperonin; Code: R; COG: COG4248. (646 aa) |
| | udk | Uridine/cytidine kinase; Code: F; COG: COG0572. (231 aa) |
| | cobU | Cobinamide kinase/cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (181 aa) |
| | yegS | Conserved hypothetical protein; Probably phosphorylates lipids; the in vivo substrate is unknown. (299 aa) |
| | SDY_2273 | Putative kinase; Code: G; COG: COG0524; Belongs to the carbohydrate kinase PfkB family. (321 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Code: H; COG: COG0351. (266 aa) |
| | thiM | Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | fruK | Fructose-1-phosphate kinase; Code: G; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | ycaH | YcaH; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (328 aa) |
| | cmk | Cytidylate kinase; Code: F; COG: COG0283. (227 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | SDY_2579 | Putative sensor protein; Code: T; COG: COG3275. (565 aa) |
| | glk | Glucokinase; Code: G; COG: COG0837; Belongs to the bacterial glucokinase family. (321 aa) |
| | metL | Aspartokinase II and homoserine dehydrogenase II; Code: E; COG: COG0527; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | ptsI | PEP-protein phosphotransferase system enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa) |
| | pdxK | Pyridoxal/pyridoxine/pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa) |
| | murP | Putative PTS enzyme II; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring. (474 aa) |
| | narQ | Sensor for nitrate reductase system; Protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850. (566 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (688 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | yfhK | Putative 2-component sensor protein; Code: T; COG: COG0642. (496 aa) |
| | yfjB | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | cysC | Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | ygcE | Putative kinase; Code: G; COG: COG1070. (492 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | barA | Sensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa) |
| | fucK | L-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family. (482 aa) |
| | ptsP | PTS system, enzyme I, transcriptional regulator (with NPR and NTR proteins); Code: T; COG: COG3605; Belongs to the PEP-utilizing enzyme family. (748 aa) |
| | yggC | Putative kinase; Code: H; COG: COG1072. (237 aa) |
| | pgk | Phosphoglycerate kinase; Code: G; COG: COG0126; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | fba | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | qseC | Quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642. (449 aa) |
| | hldE | Putative kinase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (477 aa) |
| | ygiG | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa) |
| | tdcD | Putative kinase; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (406 aa) |
| | yhaD | Conserved hypothetical protein; Code: G; COG: COG1929; orf; Belongs to the glycerate kinase type-1 family. (408 aa) |
| | arcB | Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642. (778 aa) |
| | yhcI | Putative NAGC-like transcriptional regulator; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (302 aa) |
| | gntK | Gluconokinase 2, thermoresistant; Code: G; COG: COG3265. (162 aa) |
