(22 nodes) Respiratory electron transport chain network (Shigella dysenteriae)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	hyfB	Hydrogenase 4 membrane subunit; Code: CP; COG: COG0651. (672 aa)
	cydA	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271. (523 aa)
	hyaB	Hydrogenase-1 large subunit; Code: C; COG: COG0374. (568 aa)
	hyaC	Probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit; Code: C; COG: COG1969. (235 aa)
	appC	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins. (514 aa)
	SDY_1566	Putative DMSO reductase anchor subunit; Code: R; COG: COG3302. (284 aa)
	fdnI	Formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit; Code: C; COG: COG2864. (217 aa)
	cybB	Cytochrome b(561); Code: C; COG: COG3038. (188 aa)
	ydhU	Conserved hypothetical protein; Code: C; COG: COG4117; orf. (261 aa)
	dld	D-lactate dehydrogenase, FAD protein; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (571 aa)
	SDY_2312	Putative cytochrome; Code: C; COG: COG3038. (188 aa)
	dmsC	Anaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302. (287 aa)
	nuoN	NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (425 aa)
	nuoM	NADH dehydrogenase I chain M; Code: C; COG: COG1008. (509 aa)
	nuoL	NADH dehydrogenase I chain L; Code: CP; COG: COG1009. (613 aa)
	nuoK	NADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
	nuoG	NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (910 aa)
	nuoC	NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. (600 aa)
	hyfG	Hydrogenase 4 subunit; Code: C; COG: COG3261. (571 aa)
	hycE	Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261. (569 aa)
	hybC	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
	fdoI	Formate dehydrogenase, cytochrome B556 (FDO) subunit; Code: C; COG: COG2864. (211 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
appC	cydA	SDY_0953	SDY_0680	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	0.923
appC	hyaB	SDY_0953	SDY_0948	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	Hydrogenase-1 large subunit; Code: C; COG: COG0374.	0.461
appC	nuoC	SDY_0953	SDY_2482	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.	0.638
appC	nuoG	SDY_0953	SDY_2479	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family.	0.555
appC	nuoK	SDY_0953	SDY_2475	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family.	0.556
appC	nuoL	SDY_0953	SDY_2474	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain L; Code: CP; COG: COG1009.	0.556
appC	nuoM	SDY_0953	SDY_2473	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain M; Code: C; COG: COG1008.	0.554
appC	nuoN	SDY_0953	SDY_2472	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.	0.556
cydA	appC	SDY_0680	SDY_0953	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins.	0.923
cydA	nuoC	SDY_0680	SDY_2482	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.	0.638
cydA	nuoG	SDY_0680	SDY_2479	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family.	0.659
cydA	nuoK	SDY_0680	SDY_2475	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family.	0.556
cydA	nuoL	SDY_0680	SDY_2474	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain L; Code: CP; COG: COG1009.	0.556
cydA	nuoM	SDY_0680	SDY_2473	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain M; Code: C; COG: COG1008.	0.554
cydA	nuoN	SDY_0680	SDY_2472	Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271.	NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.	0.556
dld	nuoC	SDY_2155	SDY_2482	D-lactate dehydrogenase, FAD protein; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.	NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.	0.608
dmsC	fdnI	SDY_2365	SDY_1606	Anaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302.	Formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit; Code: C; COG: COG2864.	0.564
dmsC	fdoI	SDY_2365	SDY_3851	Anaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302.	Formate dehydrogenase, cytochrome B556 (FDO) subunit; Code: C; COG: COG2864.	0.499
dmsC	hybC	SDY_2365	SDY_3079	Anaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302.	Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.	0.499
dmsC	nuoC	SDY_2365	SDY_2482	Anaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302.	NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.	0.499