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nuoG nuoG nuoC nuoC hyfB hyfB hyfG hyfG SDY_2792 SDY_2792 hycE hycE hybC hybC mdh mdh ppc ppc fdoG fdoG fdoH fdoH fdoI fdoI ubiE ubiE aceK aceK frdB frdB frdA frdA aspA aspA hyaC hyaC appC appC SDY_1566 SDY_1566 fdnH fdnH fdnI fdnI cybB cybB fumC fumC ydhU ydhU SDY_1982 SDY_1982 icdA icdA dld dld SDY_2312 SDY_2312 dmsC dmsC glpC glpC nuoN nuoN nuoM nuoM nuoL nuoL nuoK nuoK acnB acnB gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD cydA cydA yojH yojH napB napB napC napC hyaB hyaB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (910 aa)
nuoCNADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. (600 aa)
hyfBHydrogenase 4 membrane subunit; Code: CP; COG: COG0651. (672 aa)
hyfGHydrogenase 4 subunit; Code: C; COG: COG3261. (571 aa)
SDY_2792Conserved hypothetical protein; Code: I; COG: COG2867; orf. (158 aa)
hycELarge subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261. (569 aa)
hybCProbable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa)
fdoGFormate dehydrogenase-O, major subunit; Code: C; COG: COG0243. (1016 aa)
fdoHFormate dehydrogenase-O, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
fdoIFormate dehydrogenase, cytochrome B556 (FDO) subunit; Code: C; COG: COG2864. (211 aa)
ubiEUbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
aceKIsocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (578 aa)
frdBFumarate reductase, anaerobic, iron-sulfur protein subunit; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdAFumarate reductase, anaerobic, flavoprotein subunit; Code: C; COG: COG1053. (602 aa)
aspAAspartate ammonia-lyase; Aspartase; Code: E; COG: COG1027. (493 aa)
hyaCProbable Ni/Fe-hydrogenase 1 b-type cytochrome subunit; Code: C; COG: COG1969. (235 aa)
appCProbable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins. (514 aa)
SDY_1566Putative DMSO reductase anchor subunit; Code: R; COG: COG3302. (284 aa)
fdnHFormate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
fdnIFormate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit; Code: C; COG: COG2864. (217 aa)
cybBCytochrome b(561); Code: C; COG: COG3038. (188 aa)
fumCFumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
ydhUConserved hypothetical protein; Code: C; COG: COG4117; orf. (261 aa)
SDY_1982Hypothetical protein. (166 aa)
icdAIsocitrate dehydrogenase; Code: C; COG: COG0538. (416 aa)
dldD-lactate dehydrogenase, FAD protein; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (571 aa)
SDY_2312Putative cytochrome; Code: C; COG: COG3038. (188 aa)
dmsCAnaerobic dimethyl sulfoxide reductase subunit C; Code: R; COG: COG3302. (287 aa)
glpCSn-glycerol-3-phosphate dehydrogenase (anaerobic), K-small subunit; Code: C; COG: COG0247. (396 aa)
nuoNNADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (425 aa)
nuoMNADH dehydrogenase I chain M; Code: C; COG: COG1008. (509 aa)
nuoLNADH dehydrogenase I chain L; Code: CP; COG: COG1009. (613 aa)
nuoKNADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
acnBAconitate hydrase B; Code: C; COG: COG1049; Belongs to the aconitase/IPM isomerase family. (865 aa)
gltACitrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family. (427 aa)
sdhCSuccinate dehydrogenase; Cytochrome b556; Code: C; COG: COG2009. (129 aa)
sdhDSuccinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Code: C; COG: COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucA2-oxoglutarate dehydrogenase, decarboxylase component; Code: C; COG: COG0567. (933 aa)
sucB2-oxoglutarate dehydrogenase, dihydrolipoyltranssuccinase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
cydACytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271. (523 aa)
yojHConserved hypothetical protein; Code: R; COG: COG0579; orf. (548 aa)
napBCytochrome c-type protein; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
napCCytochrome c-type protein; Code: C; COG: COG3005. (200 aa)
hyaBHydrogenase-1 large subunit; Code: C; COG: COG0374. (568 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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