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htpG htpG rcsC rcsC yojN yojN narX narX rstB rstB phoQ phoQ yehU yehU baeS baeS SDY_2579 SDY_2579 narQ narQ yfhK yfhK barA barA parE parE qseC qseC arcB arcB envZ envZ hydH hydH cpxA cpxA glnL glnL basS basS SDY_4127 SDY_4127 uhpB uhpB gyrB gyrB yjdH yjdH mutL mutL evgS evgS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
htpGChaperone Hsp90; Molecular chaperone. Has ATPase activity. (624 aa)
rcsCSensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
yojNPutative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa)
narXNitrate/nitrate sensor; Histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850. (598 aa)
rstBSensor histidine protein kinase; RstA regulator; Code: T; COG: COG0642. (433 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
yehUPutative 2-component sensor protein; Code: T; COG: COG3275. (561 aa)
baeSSensor protein for BaeR; Code: T; COG: COG0642. (467 aa)
SDY_2579Putative sensor protein; Code: T; COG: COG3275. (565 aa)
narQSensor for nitrate reductase system; Protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850. (566 aa)
yfhKPutative 2-component sensor protein; Code: T; COG: COG0642. (496 aa)
barASensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa)
qseCQuorum sensing Escherichia coli regulator C; Code: T; COG: COG0642. (449 aa)
arcBAerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642. (778 aa)
envZProtein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa)
hydHSensor kinase for HydG hydrogenase 3 activity; Code: T; COG: COG0642. (458 aa)
cpxAHistidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa)
glnLHistidine protein kinase sensor for GlnG regulator; Nitrogen regulator II, NRII; Code: T; COG: COG3852. (349 aa)
basSSensor protein for basR; Code: T; COG: COG0642. (363 aa)
SDY_4127Putative histidine kinase; Code: T; COG: COG0642. (754 aa)
uhpBSensor histidine protein kinase phosphorylates UhpA; Code: T; COG: COG3851. (501 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (804 aa)
yjdHPutative 2-component sensor protein; Code: T; COG: COG3290. (543 aa)
mutLMutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (615 aa)
evgSPutative sensor for regulator EvgA; Code: ET; COG: COG0834. (1197 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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