18 items (Shigella dysenteriae) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	adiY	Putative ARAC-type regulatory protein; Code: K; COG: COG2207. (253 aa)
	rfaH	Transcription antitermination protein RfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. (162 aa)
	nusG	Component in transcription antitermination; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...] (181 aa)
	envZ	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa)
	ompR	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa)
	hmpA	Dihydropteridine reductase, ferrisiderophore reductase activity; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
	flgI	FlgI; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
	ptsG	PTS system, glucose-specific IIBC component; Code: G; COG: COG1263. (477 aa)
	phoQ	Sensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
	phoP	Transcriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
	gapA	Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
	cysB	Positive transcriptional regulator for cysteine regulon; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family. (324 aa)
	zwf	Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
	pnuC	Required for NMN transport; Code: H; COG: COG3201. (239 aa)
	entB	2,3-dihydro-2,3-dihydroxybenzoate synthetase; Isochroismatase; Code: Q; COG: COG1535. (285 aa)
	purE	AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
	uhpT	Hexose phosphate transport protein; Code: G; COG: COG2271. (463 aa)
	mopA	GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adiY	cysB	SDY_4097	SDY_1345	Putative ARAC-type regulatory protein; Code: K; COG: COG2207.	Positive transcriptional regulator for cysteine regulon; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.	0.404
cysB	adiY	SDY_1345	SDY_4097	Positive transcriptional regulator for cysteine regulon; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.	Putative ARAC-type regulatory protein; Code: K; COG: COG2207.	0.404
envZ	ompR	SDY_3672	SDY_3671	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.999
envZ	phoP	SDY_3672	SDY_2022	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.870
envZ	phoQ	SDY_3672	SDY_2023	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	Sensor protein PhoQ; Code: T; COG: COG0642.	0.436
gapA	mopA	SDY_1488	SDY_4449	Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.614
gapA	zwf	SDY_1488	SDY_1138	Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.	0.882
mopA	gapA	SDY_4449	SDY_1488	GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.614
mopA	nusG	SDY_4449	SDY_3746	GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	Component in transcription antitermination; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...]	0.428
nusG	mopA	SDY_3746	SDY_4449	Component in transcription antitermination; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...]	GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.428
nusG	rfaH	SDY_3746	SDY_3903	Component in transcription antitermination; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...]	Transcription antitermination protein RfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.	0.518
ompR	envZ	SDY_3671	SDY_3672	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	0.999
ompR	phoQ	SDY_3671	SDY_2023	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	Sensor protein PhoQ; Code: T; COG: COG0642.	0.858
phoP	envZ	SDY_2022	SDY_3672	Transcriptional regulatory protein; Code: TK; COG: COG0745.	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	0.870
phoP	phoQ	SDY_2022	SDY_2023	Transcriptional regulatory protein; Code: TK; COG: COG0745.	Sensor protein PhoQ; Code: T; COG: COG0642.	0.999
phoQ	envZ	SDY_2023	SDY_3672	Sensor protein PhoQ; Code: T; COG: COG0642.	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	0.436
phoQ	ompR	SDY_2023	SDY_3671	Sensor protein PhoQ; Code: T; COG: COG0642.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.858
phoQ	phoP	SDY_2023	SDY_2022	Sensor protein PhoQ; Code: T; COG: COG0642.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.999
ptsG	uhpT	SDY_2049	SDY_4147	PTS system, glucose-specific IIBC component; Code: G; COG: COG1263.	Hexose phosphate transport protein; Code: G; COG: COG2271.	0.513
ptsG	zwf	SDY_2049	SDY_1138	PTS system, glucose-specific IIBC component; Code: G; COG: COG1263.	Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.	0.887