14 items (Shigella dysenteriae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	phoP	Transcriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
	lpdA	Lipoamide dehydrogenase (NADH); Component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; Code: C; COG: COG1249. (474 aa)
	lacZ	beta-D-galactosidase; Code: G; COG: COG3250; Belongs to the glycosyl hydrolase 2 family. (969 aa)
	acrA	Acridine efflux pump; Code: M; COG: COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
	torR	Response transcriptional regulator for torA; Sensor TorS; Code: TK; COG: COG0745. (230 aa)
	gadB	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family. (466 aa)
	icdA	Isocitrate dehydrogenase; Code: C; COG: COG0538. (416 aa)
	rpoS	RNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
	arcB	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642. (778 aa)
	crp	Cyclic AMP receptor protein; Code: T; COG: COG0664. (210 aa)
	gadA	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family. (464 aa)
	hdeD	Conserved hypothetical protein; Code: S; COG: COG3247; orf. (190 aa)
	thdF	GTP-binding protein; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (454 aa)
	evgA	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197. (204 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
arcB	crp	SDY_3391	SDY_3519	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	Cyclic AMP receptor protein; Code: T; COG: COG0664.	0.519
arcB	evgA	SDY_3391	SDY_4477	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	0.903
arcB	lpdA	SDY_3391	SDY_0146	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	Lipoamide dehydrogenase (NADH); Component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; Code: C; COG: COG1249.	0.483
arcB	phoP	SDY_3391	SDY_2022	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.972
arcB	torR	SDY_3391	SDY_0969	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	Response transcriptional regulator for torA; Sensor TorS; Code: TK; COG: COG0745.	0.976
crp	arcB	SDY_3519	SDY_3391	Cyclic AMP receptor protein; Code: T; COG: COG0664.	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	0.519
crp	evgA	SDY_3519	SDY_4477	Cyclic AMP receptor protein; Code: T; COG: COG0664.	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	0.468
crp	phoP	SDY_3519	SDY_2022	Cyclic AMP receptor protein; Code: T; COG: COG0664.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.472
crp	rpoS	SDY_3519	SDY_2940	Cyclic AMP receptor protein; Code: T; COG: COG0664.	RNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.771
crp	torR	SDY_3519	SDY_0969	Cyclic AMP receptor protein; Code: T; COG: COG0664.	Response transcriptional regulator for torA; Sensor TorS; Code: TK; COG: COG0745.	0.410
evgA	arcB	SDY_4477	SDY_3391	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.	0.903
evgA	crp	SDY_4477	SDY_3519	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Cyclic AMP receptor protein; Code: T; COG: COG0664.	0.468
evgA	gadA	SDY_4477	SDY_3532	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	0.470
evgA	gadB	SDY_4477	SDY_1615	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	0.420
evgA	phoP	SDY_4477	SDY_2022	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.789
evgA	rpoS	SDY_4477	SDY_2940	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	RNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.449
evgA	torR	SDY_4477	SDY_0969	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	Response transcriptional regulator for torA; Sensor TorS; Code: TK; COG: COG0745.	0.593
gadA	evgA	SDY_3532	SDY_4477	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.	0.470
gadA	gadB	SDY_3532	SDY_1615	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	0.901
gadA	hdeD	SDY_3532	SDY_3542	Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.	Conserved hypothetical protein; Code: S; COG: COG3247; orf.	0.558