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fumA fumA ksgA ksgA gltA gltA sucA sucA grxA grxA ptrB ptrB narL narL narJ narJ ogt ogt yoaG yoaG yeaR yeaR fumC fumC nfo nfo SDY_2192 SDY_2192 ybjW ybjW hmpA hmpA rseC rseC rpoE rpoE recA recA ygaA ygaA norV norV mdh mdh crp crp oxyR oxyR ytfE ytfE yjeB yjeB soxR soxR soxS soxS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fumAFumarase A; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
ksgAS-adenosylmethionine-6-N',N'-adenosyl dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (273 aa)
gltACitrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family. (427 aa)
sucA2-oxoglutarate dehydrogenase, decarboxylase component; Code: C; COG: COG0567. (933 aa)
grxAGlutaredoxin1 redox coenzyme for glutathione-dependent ribonucleotide reductase; Code: O; COG: COG0695. (85 aa)
ptrBProtease II; Code: E; COG: COG1770. (686 aa)
narLNarL; Pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; Code: TK; COG: COG2197. (216 aa)
narJNitrate reductase 1, delta subunit, assembly function; Code: C; COG: COG2180. (236 aa)
ogtO-6-alkylguanine-DNA/cysteine-protein methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa)
yoaGConserved hypothetical protein. (60 aa)
yeaRConserved hypothetical protein; Code: P; COG: COG3615; orf. (119 aa)
fumCFumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa)
SDY_2192Putative chaperonin; Code: R; COG: COG4248. (646 aa)
ybjWPutative prismane; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (552 aa)
hmpADihydropteridine reductase, ferrisiderophore reductase activity; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
rseCsigma-E factor, negative regulatory protein; Code: T; COG: COG3086. (159 aa)
rpoERNA polymerase; sigma-E factor; heat shock and oxidative stress; Code: K; COG: COG1595; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
recADNA-dependent ATPase, DNA- and ATP-dependent coprotease; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
ygaAPutative 2-component transcriptional regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. (529 aa)
norVPutative flavodoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (479 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
crpCyclic AMP receptor protein; Code: T; COG: COG0664. (210 aa)
oxyROxyR; Activator of hydrogen peroxide-inducible genes; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family. (305 aa)
ytfEConserved hypothetical protein; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. (220 aa)
yjeBConserved hypothetical protein; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
soxRRedox-sensing activator of soxS; Code: K; COG: COG0789. (154 aa)
soxSRegulation of superoxide response regulon; Code: K; COG: COG2207. (107 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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