STRINGSTRING
hlpA hlpA rcsF rcsF soxS soxS tig tig fepA fepA rlpB rlpB rcsC rcsC yojN yojN ompC ompC ompA ompA wrbA wrbA cutC cutC dsbB dsbB nhaB nhaB SDY_1555 SDY_1555 marA marA lpp lpp phoP phoP phoQ phoQ rne rne ompF ompF lrp lrp rseB rseB rseA rseA rpoE rpoE bamD bamD rpoS rpoS rpoD rpoD degS degS crp crp gor gor ompR ompR envZ envZ nusG nusG oxyR oxyR yiiO yiiO cpxA cpxA dsbA dsbA rho rho fecA fecA soxR soxR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hlpAHistone-like protein; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (161 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
soxSRegulation of superoxide response regulon; Code: K; COG: COG2207. (107 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. (432 aa)
fepAOuter membrane receptor for ferric enterobactin (enterochelin) and colicins B and D; Code: P; COG: COG4771. (746 aa)
rlpBMinor lipoprotein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (193 aa)
rcsCSensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
yojNPutative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa)
ompCOuter membrane protein 1b; Ib;c; Code: M; COG: COG3203; Belongs to the Gram-negative porin family. (375 aa)
ompAOuter membrane protein 3a; II*;G;d; Code: M; COG: COG2885; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (350 aa)
wrbAAffects association of trp repressor and operator; Code: R; COG: COG0655. (198 aa)
cutCCopper homeostasis protein; Participates in the control of copper homeostasis. (248 aa)
dsbBDsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (176 aa)
nhaBNa+/H+ antiporter, pH independent; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (513 aa)
SDY_1555Conserved hypothetical protein; Code: E; COG: COG3591; orf; Belongs to the peptidase S1B family. (273 aa)
marAMarA; Multiple antibiotic resistance; transcriptional activator of defense systems; Code: K; COG: COG2207. (129 aa)
lppMurein lipoprotein; Code: M; COG: COG4238. (78 aa)
phoPTranscriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
rneRNase E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa)
ompFOuter membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family. (362 aa)
lrpRegulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system; Code: K; COG: COG1522. (164 aa)
rseBRegulates activity of sigma-E factor; Code: T; COG: COG3026. (318 aa)
rseAsigma-E factor, negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic [...] (216 aa)
rpoERNA polymerase; sigma-E factor; heat shock and oxidative stress; Code: K; COG: COG1595; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
bamDConserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
rpoSRNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
rpoDRNA polymerase, sigma(70) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (613 aa)
degSProtease; Code: O; COG: COG0265. (355 aa)
crpCyclic AMP receptor protein; Code: T; COG: COG0664. (210 aa)
gorGlutathione oxidoreductase; Code: C; COG: COG1249. (450 aa)
ompRResponse regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa)
envZProtein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa)
nusGComponent in transcription antitermination; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...] (181 aa)
oxyROxyR; Activator of hydrogen peroxide-inducible genes; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family. (305 aa)
yiiOUncharacterized periplasmic protein; Code: UNTP; COG: COG3678. (167 aa)
cpxAHistidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa)
dsbAProtein disulfide isomerase I; Essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526. (208 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
fecACitrate-dependent iron transport, outer membrane receptor; Code: P; COG: COG4772. (774 aa)
soxRRedox-sensing activator of soxS; Code: K; COG: COG0789. (154 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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