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wzxE wzxE rcsB rcsB yojN yojN csgE csgE csgF csgF amiB amiB yhjO yhjO nlpD nlpD rpoS rpoS purL purL purM purM purF purF himD himD rne rne phoQ phoQ phoP phoP nhaA nhaA mgrB mgrB himA himA gapA gapA csgG csgG envZ envZ yrfF yrfF purH purH purD purD cpxR cpxR ompR ompR cpxA cpxA rfaH rfaH pgi pgi fbp fbp rcsC rcsC galE galE purK purK rcsF rcsF dksA dksA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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wzxEPutative cytochrome; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
rcsBPositive response regulator for colanic capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
yojNPutative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa)
csgECurli production assembly/transport component; 2nd curli operon. (129 aa)
csgFCurli production assembly/transport component; 2nd curli operon. (138 aa)
amiBN-acetylmuramoyl-l-alanine amidase II; A murein hydrolase; Code: M; COG: COG0860. (445 aa)
yhjOPutative cellulose synthase; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (888 aa)
nlpDLipoprotein; Code: M; COG: COG0739. (379 aa)
rpoSRNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
purLPhosphoribosylformyl-glycineamide synthetase FGAM synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
purMAIR synthetase; Code: F; COG: COG0150. (345 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
himDIntegration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa)
rneRNase E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
phoPTranscriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
nhaANa+/H antiporter, pH dependent; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
mgrBConserved hypothetical protein; PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. (47 aa)
himAIntegration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
csgGCurli production assembly/transport component; 2nd curli operon; Code: M; COG: COG1462. (277 aa)
envZProtein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa)
yrfFPutative dehydrogenase. (711 aa)
purHAICAR formyltransferase; IMP cyclohydrolase; Code: F; COG: COG0138. (529 aa)
purDGAR synthetase; Code: F; COG: COG0151. (429 aa)
cpxRTranscriptional regulator in 2-component system; Code: TK; COG: COG0745. (232 aa)
ompRResponse regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa)
cpxAHistidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa)
rfaHTranscription antitermination protein RfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. (162 aa)
pgiGlucosephosphate isomerase; Code: G; COG: COG0166; Belongs to the GPI family. (549 aa)
fbpFructose-bisphosphatase; Code: G; COG: COG0158. (332 aa)
rcsCSensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
galEUDP-galactose-4-epimerase; Code: M; COG: COG1087; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
purKAIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
dksAdnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (151 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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