9 items (Shigella dysenteriae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

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Your Input:
	tonB	TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (239 aa)
	lacZ	beta-D-galactosidase; Code: G; COG: COG3250; Belongs to the glycosyl hydrolase 2 family. (969 aa)
	prrA	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629. (656 aa)
	exbB	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811. (244 aa)
	exbD	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848. (141 aa)
	shuA	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629. (660 aa)
	ompR	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa)
	envZ	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa)
	yhjV	Putative transporter protein; Code: E; COG: COG0814. (423 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
envZ	ompR	SDY_3672	SDY_3671	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.999
exbB	exbD	SDY_3067	SDY_3068	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	0.999
exbB	prrA	SDY_3067	SDY_1235	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	0.816
exbB	shuA	SDY_3067	SDY_3554	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	0.603
exbB	tonB	SDY_3067	SDY_1316	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.977
exbD	exbB	SDY_3068	SDY_3067	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	0.999
exbD	prrA	SDY_3068	SDY_1235	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	0.808
exbD	shuA	SDY_3068	SDY_3554	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	0.578
exbD	tonB	SDY_3068	SDY_1316	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.992
lacZ	ompR	SDY_0378	SDY_3671	beta-D-galactosidase; Code: G; COG: COG3250; Belongs to the glycosyl hydrolase 2 family.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.402
ompR	envZ	SDY_3671	SDY_3672	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.	0.999
ompR	lacZ	SDY_3671	SDY_0378	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	beta-D-galactosidase; Code: G; COG: COG3250; Belongs to the glycosyl hydrolase 2 family.	0.402
prrA	exbB	SDY_1235	SDY_3067	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	0.816
prrA	exbD	SDY_1235	SDY_3068	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	0.808
prrA	shuA	SDY_1235	SDY_3554	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	0.879
prrA	tonB	SDY_1235	SDY_1316	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.795
shuA	exbB	SDY_3554	SDY_3067	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	ExbB; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0811.	0.603
shuA	exbD	SDY_3554	SDY_3068	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	ExbD; Uptake of enterochelin; tonB-dependent uptake of B colicins; Code: U; COG: COG0848.	0.578
shuA	prrA	SDY_3554	SDY_1235	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	Putative outer membrane receptor; Probably tonB dependent; Code: P; COG: COG1629.	0.879
shuA	tonB	SDY_3554	SDY_1316	Outer membrane heme/hemoglobin receptor; Code: P; COG: COG1629.	TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.740