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rcsB rcsB vsr vsr yedA yedA uvrY uvrY narL narL narX narX rstA rstA rstB rstB cspC cspC phoP phoP phoQ phoQ baeR baeR hisA hisA cspD cspD yfhA yfhA yfhK yfhK csrA csrA barA barA qseC qseC ygiX ygiX glnG glnG ilvA ilvA cspA cspA rcsC rcsC cspE cspE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rcsBPositive response regulator for colanic capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
vsrDNA mismatch endonuclease, patch repair protein; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (156 aa)
yedAPutative transmembrane subunit; Code: GER; COG: COG0697. (306 aa)
uvrYPutative 2-component transcriptional regulator; Code: TK; COG: COG2197. (218 aa)
narLNarL; Pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; Code: TK; COG: COG2197. (216 aa)
narXNitrate/nitrate sensor; Histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850. (598 aa)
rstAResponse transcriptional regulatory protein; RstB sensor; Code: TK; COG: COG0745. (238 aa)
rstBSensor histidine protein kinase; RstA regulator; Code: T; COG: COG0642. (433 aa)
cspCCold shock protein; Code: K; COG: COG1278. (69 aa)
phoPTranscriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
baeRTranscriptional response regulatory protein; Sensor BaeS; Code: TK; COG: COG0745. (240 aa)
hisAN-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4- imidazolecarboxamide isomerase; Code: E; COG: COG0106. (246 aa)
cspDCold shock protein; Code: K; COG: COG1278. (74 aa)
yfhAPutative 2-component transcriptional regulator; Code: T; COG: COG2204. (444 aa)
yfhKPutative 2-component sensor protein; Code: T; COG: COG0642. (496 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
barASensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa)
qseCQuorum sensing Escherichia coli regulator C; Code: T; COG: COG0642. (449 aa)
ygiXPutative 2-component transcriptional regulator; Code: TK; COG: COG0745. (219 aa)
glnGResponse regulator for gln; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
cspACold shock protein 7.4; Transcriptional activator of hns; Code: K; COG: COG1278. (70 aa)
rcsCSensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
cspECold shock protein; Code: K; COG: COG1278. (69 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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