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fabB fabB dapB dapB ilvI ilvI dapD dapD gltA gltA sdhC sdhC sdhD sdhD sdhB sdhB sucA sucA sucB sucB sucC sucC sucD sucD bioD bioD bioC bioC bioF bioF bioA bioA yojH yojH pykA pykA fabI fabI bioD-2 bioD-2 fumC fumC pykF pykF fabH fabH usg usg dapE dapE dapA dapA lysA lysA mdh mdh birA birA metB metB metE metE dapF dapF ilvC ilvC ilvA ilvA ilvD ilvD ilvE ilvE ilvM ilvM ilvG ilvG ilvN ilvN ilvB ilvB lysC lysC tyrB tyrB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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fabB3-oxoacyl-[acyl-carrier-protein] synthase I; Code: IQ; COG: COG0304; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
ilvIAcetolactate synthase isozyme III large subunit; Code: EH; COG: COG0028. (574 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Code: E; COG: COG2171; Belongs to the transferase hexapeptide repeat family. (274 aa)
gltACitrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family. (427 aa)
sdhCSuccinate dehydrogenase; Cytochrome b556; Code: C; COG: COG2009. (129 aa)
sdhDSuccinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhBSuccinate dehydrogenase, iron sulfur protein; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucA2-oxoglutarate dehydrogenase, decarboxylase component; Code: C; COG: COG0567. (933 aa)
sucB2-oxoglutarate dehydrogenase, dihydrolipoyltranssuccinase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (225 aa)
bioCBiotin biosynthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioA7,8-diaminopelargonic acid synthetase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
yojHConserved hypothetical protein; Code: R; COG: COG0579; orf. (548 aa)
pykAPyruvate kinase II; Glucose stimulated; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (480 aa)
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Code: I; COG: COG0623. (262 aa)
bioD-2Conserved hypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (235 aa)
fumCFumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
pykFPyruvate kinase I, fructose stimulated; Formerly F; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (470 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa)
usgPutative PTS system enzyme II A component; Code: E; COG: COG0136; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa)
dapEN-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
birAbiotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (321 aa)
metBCystathionine gamma-synthase; Code: E; COG: COG0626. (386 aa)
metETetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa)
ilvDDihydroxyacid dehydratase; Code: EG; COG: COG0129; Belongs to the IlvD/Edd family. (616 aa)
ilvEBranched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
ilvMAcetolactate synthase II, valine insensitive, small subunit; Code: S; COG: COG3978. (87 aa)
ilvGAcetolactate synthase II, large subunit; Code: EH; COG: COG0028. (548 aa)
ilvNAcetolactate synthase I, valine sensitive, small subunit; Code: E; COG: COG0440. (96 aa)
ilvBAcetolactate synthase I,valine-sensitive, large subunit; Code: EH; COG: COG0028. (562 aa)
lysCAspartokinase III; Lysine sensitive; Code: E; COG: COG0527; Belongs to the aspartokinase family. (449 aa)
tyrBTyrosine repressible; Code: E; COG: COG1448. (397 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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