STRINGSTRING
pfs pfs qseC qseC mtr mtr arsR arsR cpxR cpxR cpxA cpxA mutL mutL creB creB baeR baeR narL narL phoQ phoQ narX narX phoP phoP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pfsConserved hypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP ph [...] (232 aa)
qseCQuorum sensing Escherichia coli regulator C; Code: T; COG: COG0642. (449 aa)
mtrTryptophan-specific transport protein; Code: E; COG: COG0814. (414 aa)
arsRTranscriptional repressor of chromosomal ars operon; Code: K; COG: COG0640. (117 aa)
cpxRTranscriptional regulator in 2-component system; Code: TK; COG: COG0745. (232 aa)
cpxAHistidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa)
mutLMutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (615 aa)
creBCatabolic regulation response regulator; Code: TK; COG: COG0745. (229 aa)
baeRTranscriptional response regulatory protein; Sensor BaeS; Code: TK; COG: COG0745. (240 aa)
narLNarL; Pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; Code: TK; COG: COG2197. (216 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
narXNitrate/nitrate sensor; Histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850. (598 aa)
phoPTranscriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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