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arnT arnT hpt hpt lacZ lacZ safA safA ycgW ycgW phoP phoP phoQ phoQ emrY emrY emrK emrK rpoS rpoS barA barA arcB arcB cytR cytR menA menA mgtA mgtA evgA evgA evgS evgS ubiA ubiA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
arnTConserved hypothetical protein; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (550 aa)
hptHypoxanthine phosphoribosyltransferase; Code: F; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
lacZbeta-D-galactosidase; Code: G; COG: COG3250; Belongs to the glycosyl hydrolase 2 family. (969 aa)
safAConserved hypothetical protein; Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions; Belongs to the SafA family. (65 aa)
ycgWConserved hypothetical protein; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation; Belongs to the IraM/RssC family. (107 aa)
phoPTranscriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
phoQSensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
emrYMultidrug resistance protein Y; Code: GEPR; COG: COG0477; Belongs to the major facilitator superfamily. (512 aa)
emrKMultidrug resistance protein K; Code: V; COG: COG1566. (387 aa)
rpoSRNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
barASensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa)
arcBAerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642. (778 aa)
cytRRegulator for deo operon, udp, cdd, tsx, nupC, and nupG; Code: K; COG: COG1609. (341 aa)
menAMenA; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (308 aa)
mgtAMg2+ transport ATPase, P-type 1; Code: P; COG: COG0474. (898 aa)
evgAPutative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197. (204 aa)
evgSPutative sensor for regulator EvgA; Code: ET; COG: COG0834. (1197 aa)
ubiA4-hydroxybenzoate-octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (290 aa)
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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