14 items (Shigella dysenteriae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cpxR	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745. (232 aa)
	cpxA	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa)
	yiiO	Uncharacterized periplasmic protein; Code: UNTP; COG: COG3678. (167 aa)
	ompR	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa)
	aer	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840. (506 aa)
	rpoE	RNA polymerase; sigma-E factor; heat shock and oxidative stress; Code: K; COG: COG1595; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
	pta	Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
	ompF	Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family. (362 aa)
	phoQ	Sensor protein PhoQ; Code: T; COG: COG0642. (486 aa)
	phoP	Transcriptional regulatory protein; Code: TK; COG: COG0745. (223 aa)
	slyA	Transcriptional regulator for cryptic hemolysin; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (146 aa)
	cnu	Conserved hypothetical protein; Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC; Belongs to the Hha/YmoA/Cnu family. (71 aa)
	hha	Haemolysin expression modulating protein. (72 aa)

Your Current Organism:

Shigella dysenteriae

NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ackA	pta	SDY_2492	SDY_2493	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.999
ackA	yiiO	SDY_2492	SDY_3833	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Uncharacterized periplasmic protein; Code: UNTP; COG: COG3678.	0.405
aer	cpxR	SDY_3256	SDY_3834	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	0.409
aer	ompR	SDY_3256	SDY_3671	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.465
aer	phoP	SDY_3256	SDY_2022	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.409
cpxA	cpxR	SDY_3835	SDY_3834	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	0.999
cpxA	ompF	SDY_3835	SDY_2328	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family.	0.668
cpxA	ompR	SDY_3835	SDY_3671	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.879
cpxA	phoP	SDY_3835	SDY_2022	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Transcriptional regulatory protein; Code: TK; COG: COG0745.	0.859
cpxA	pta	SDY_3835	SDY_2493	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.443
cpxA	yiiO	SDY_3835	SDY_3833	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	Uncharacterized periplasmic protein; Code: UNTP; COG: COG3678.	0.807
cpxR	aer	SDY_3834	SDY_3256	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.	0.409
cpxR	cpxA	SDY_3834	SDY_3835	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	0.999
cpxR	phoQ	SDY_3834	SDY_2023	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	Sensor protein PhoQ; Code: T; COG: COG0642.	0.805
cpxR	yiiO	SDY_3834	SDY_3833	Transcriptional regulator in 2-component system; Code: TK; COG: COG0745.	Uncharacterized periplasmic protein; Code: UNTP; COG: COG3678.	0.790
ompF	cpxA	SDY_2328	SDY_3835	Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family.	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	0.668
ompF	ompR	SDY_2328	SDY_3671	Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family.	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	0.783
ompF	phoQ	SDY_2328	SDY_2023	Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family.	Sensor protein PhoQ; Code: T; COG: COG0642.	0.664
ompR	aer	SDY_3671	SDY_3256	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.	0.465
ompR	cpxA	SDY_3671	SDY_3835	Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745.	Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.	0.879