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| | thrA | Homoserine dehydrogenase I; Code: E; COG: COG0527; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | thrC | Threonine synthase; Code: E; COG: COG0498. (428 aa) |
| | talB | Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | acnB | Aconitate hydrase B; Code: C; COG: COG1049; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | araD | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | aceE | Pyruvate dehydrogenase decarboxylase component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Pyruvate dehydrogenase dihydrolipoyltransacetylase component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (626 aa) |
| | lpdA | Lipoamide dehydrogenase (NADH); Component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; Code: C; COG: COG1249. (474 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase; Aminomutase; Code: H; COG: COG0001. (426 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Code: E; COG: COG2171; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | accA | acetylCoA carboxylase, carboxytransferase component, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | nfnB | Oxygen-insensitive NAD(P)H nitroreductase; Code: C; COG: COG0778. (217 aa) |
| | hemB | 5-aminolevulinate dehydratase; Porphobilinogen synthase; Code: H; COG: COG0113; Belongs to the ALAD family. (335 aa) |
| | pgm | Phosphoglucomutase; Code: G; COG: COG0033. (546 aa) |
| | gltA | Citrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family. (427 aa) |
| | sdhC | Succinate dehydrogenase; Cytochrome b556; Code: C; COG: COG2009. (129 aa) |
| | sdhD | Succinate dehydrogenase, hydrophobic subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhA | Succinate dehydrogenase, flavoprotein subunit; Code: C; COG: COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa) |
| | sdhB | Succinate dehydrogenase, iron sulfur protein; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa) |
| | sucA | 2-oxoglutarate dehydrogenase, decarboxylase component; Code: C; COG: COG0567. (933 aa) |
| | sucB | 2-oxoglutarate dehydrogenase, dihydrolipoyltranssuccinase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa) |
| | SDY_0673 | Putative methylaspartate ammonia-lyase; Code: E; COG: COG3799. (413 aa) |
| | glmE | Putative glutamate mutase subumit E; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (454 aa) |
| | glmS-2 | Putative glutamate mutase S; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (170 aa) |
| | gpmA | Phosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | galM | Galactose-1-epimerase; Converts alpha-aldose to the beta-anomer. (346 aa) |
| | mdaA | Modulator of drug activity A; Code: C; COG: COG0778; Belongs to the flavin oxidoreductase frp family. (240 aa) |
| | SDY_0749 | Hypothetical protein; Code: E; COG: COG1045; orf; Belongs to the transferase hexapeptide repeat family. (183 aa) |
| | ybiW | Putative formate acetyltransferase; Code: C; COG: COG1882. (810 aa) |
| | yojH | Conserved hypothetical protein; Code: R; COG: COG0579; orf. (548 aa) |
| | napA | Probable nitrate reductase 3; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | napB | Cytochrome c-type protein; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (155 aa) |
| | yccX | Conserved hypothetical protein; Code: C; COG: COG1254; orf. (92 aa) |
| | hyaA | Hydrogenase-1 small subunit; Code: C; COG: COG1740. (372 aa) |
| | torD | Part of trimethylamine-N-oxide oxidoreductase; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (199 aa) |
| | agp | Periplasmic glucose-1-phosphatase. (413 aa) |
| | ycdW | Putative dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (325 aa) |
| | SDY_1038 | Conserved hypothetical protein; Code: R; COG: COG2351; orf. (108 aa) |
| | eda | 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase; Code: G; COG: COG0800. (213 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (603 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | pykA | Pyruvate kinase II; Glucose stimulated; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (480 aa) |
| | bisZ | Biotin sulfoxide reductase 2; Code: C; COG: COG0243. (786 aa) |
| | prsA | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | hemA | 5-aminolevulinate synthesis enzyme, alternate pathway; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (418 aa) |
| | narG | Nitrate reductase 1, alpha subunit; Code: C; COG: COG5013; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa) |
| | narH | Nitrate reductase 1, beta subunit; Code: C; COG: COG1140. (512 aa) |
| | narI | Nitrate reductase 1, cytochrome b(NR), gamma subunit; Code: C; COG: COG2181. (225 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; Code: C; COG: COG1454; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa) |
| | ydbK | Putative oxidoreductase, Fe-S subunit; Code: C; COG: COG0674. (1174 aa) |
| | ldhA | Fermentative D-lactate dehydrogenase, NAD-dependent; Code: CHR; COG: COG1052; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | yeaD | Conserved hypothetical protein; Code: G; COG: COG0676; orf; Belongs to the glucose-6-phosphate 1-epimerase family. (301 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | gdhA | NADP-specific glutamate dehydrogenase; Code: E; COG: COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | adhP | Alcohol dehydrogenase; Code: R; COG: COG1064. (375 aa) |
| | gadB | Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family. (466 aa) |
| | SDY_1632 | Putative aldehyde dehydrogenase; Code: C; COG: COG1012. (470 aa) |
| | narY | Cryptic nitrate reductase 2, beta subunit; Code: C; COG: COG1140. (507 aa) |
| | narV | Cryptic nitrate reductase 2, gamma subunit; Code: C; COG: COG2181. (226 aa) |
| | patD | Putative aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (474 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | pfkB | 6-phosphofructokinase II; Suppressor of pfkA; Code: G; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. (309 aa) |
| | fumC | Fumarase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa) |
| | fumA | Fumarase A; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | pdxH | Pyridoxinephosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | ydhU | Conserved hypothetical protein; Code: C; COG: COG4117; orf. (261 aa) |
| | SDY_1904 | Conserved hypothetical protein. (69 aa) |
| | pykF | Pyruvate kinase I, fructose stimulated; Formerly F; Code: G; COG: COG0469; Belongs to the pyruvate kinase family. (470 aa) |
| | ybhE | Putative isomerase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (331 aa) |
| | icdA | Isocitrate dehydrogenase; Code: C; COG: COG0538. (416 aa) |
| | yeiG | Putative esterase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity). (278 aa) |
| | dld | D-lactate dehydrogenase, FAD protein; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (571 aa) |
| | gnd | Gluconate-6-phosphate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | SDY_2270 | Conserved hypothetical protein; Code: G; COG: COG1830; orf. (374 aa) |
| | fruA | PTS system, fructose-specific transport protein; Code: G; COG: COG1299. (563 aa) |
| | serC | 3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | pflB | Formate acetyltransferase 1; Code: C; COG: COG1882. (760 aa) |
| | ybjU | Putative arylsulfatase; Code: E; COG: COG2008. (333 aa) |
| | rhmA | Conserved hypothetical protein; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | accD | acetylCoA carboxylase, carboxytransferase component, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | fadJ | Putative enzyme; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | fadI | Putative acyltransferase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | glk | Glucokinase; Code: G; COG: COG0837; Belongs to the bacterial glucokinase family. (321 aa) |
| | gltX | Glutamate tRNA synthetase, catalytic subunit; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa) |
| | cysK | Cysteine synthase A; O-acetylserine sulfhydrolase A; Code: E; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | SDY_2645 | Putative multimodular enzyme; Code: C; COG: COG0281. (759 aa) |
| | dapE | N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | sseA | Putative thiosulfate sulfurtransferase; Code: P; COG: COG2897. (334 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | SDY_2936 | Conserved hypothetical protein. (78 aa) |
| | SDY_2938 | Phenylacrylic acid decarboxylase-like protein; Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase. (197 aa) |
| | cysC | Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | cysN | ATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa) |
| | cysD | ATP-sulfurylase, subunit 2; ATP:sulfate adenylyltransferase; probably a GTPase; Code: EH; COG: COG0175. (302 aa) |
| | cysH | 3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa) |
| | cysI | Sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Sulfite reductase (NADPH), flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | fucO | L-1,2-propanediol oxidoreductase; Code: C; COG: COG1454. (383 aa) |
| | fucA | L-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa) |
| | fucI | L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa) |
| | fucK | L-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family. (482 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | SDY_3076 | Putative hydrogenase subunit; Code: C; COG: COG1740. (372 aa) |
| | hybC | Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa) |
| | tktA | Transketolase 1 isozyme; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | yggD | Putative transcriptional regulator; Code: K; COG: COG3722. (169 aa) |
| | pgk | Phosphoglycerate kinase; Code: G; COG: COG0126; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | fba | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | rpiA | Ribosephosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Code: HE; COG: COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | tdcE | Probable formate acetyltransferase 3; Code: C; COG: COG1882. (764 aa) |
| | yhaD | Conserved hypothetical protein; Code: G; COG: COG1929; orf; Belongs to the glycerate kinase type-1 family. (408 aa) |
| | gltB | Glutamate synthase, large subunit; Code: E; COG: COG0069. (1486 aa) |
| | gltD | Glutamate synthase, small subunit; Code: ER; COG: COG0493. (472 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa) |
| | accB | acetylCoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | Acetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | argD | Acetylornithine delta-aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | nirB | Nitrite reductase (NAD(P)H) subunit; Code: C; COG: COG1251; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa) |
| | nirD | Nitrite reductase (NAD(P)H) subunit; Code: PR; COG: COG2146. (108 aa) |
| | cysG | Uroporphyrinogen III methylase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa) |
| | gadA | Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family. (464 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | gntK | Gluconokinase 2, thermoresistant; Code: G; COG: COG3265. (162 aa) |
| | glpE | Protein of glp regulon; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (108 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (540 aa) |
| | rpe | D-ribulose-5-phosphate 3-epimerase; Code: G; COG: COG0036; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | metL | Aspartokinase II and homoserine dehydrogenase II; Code: E; COG: COG0527; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Code: E; COG: COG0685; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | pflD | Formate acetyltransferase 2; Code: C; COG: COG1882. (765 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa) |
| | glpX | GlpX; Unknown function in glycerol metabolism; Code: G; COG: COG1494. (336 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | rhaB | Rhamnulokinase; Code: G; COG: COG1070. (387 aa) |
| | rhaD | Rhamnulose-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (274 aa) |
| | fdoG | Formate dehydrogenase-O, major subunit; Code: C; COG: COG0243. (1016 aa) |
| | fdoH | Formate dehydrogenase-O, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa) |
| | fdoI | Formate dehydrogenase, cytochrome B556 (FDO) subunit; Code: C; COG: COG2864. (211 aa) |
| | yihX | Putative phosphatase; Code: R; COG: COG1011. (206 aa) |
| | SDY_3863 | Hypothetical protein. (243 aa) |
| | glnA | Glutamine synthetase; Code: E; COG: COG0174. (469 aa) |
| | fadB | Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa) |
| | fadA | Thiolase I; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | SDY_3913 | Putative enzyme; Code: Q; COG: COG0412. (289 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (320 aa) |
| | hemD | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemX | Uroporphyrinogen III methylase; Code: H; COG: COG2959. (393 aa) |
| | cysE | Serine acetyltransferase; Code: E; COG: COG1045; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | yibO | Putative 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | SDY_4132 | Putative aldolase; Code: G; COG: COG0191. (286 aa) |
| | pgi | Glucosephosphate isomerase; Code: G; COG: COG0166; Belongs to the GPI family. (549 aa) |
| | lysC | Aspartokinase III; Lysine sensitive; Code: E; COG: COG0527; Belongs to the aspartokinase family. (449 aa) |
| | fumB | Fumarase B; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | fbp | Fructose-bisphosphatase; Code: G; COG: COG0158. (332 aa) |
| | yjgB | Putative oxidoreductase; Code: R; COG: COG1064. (353 aa) |
| | aceA | Isocitrate lyase; Code: C; COG: COG2224. (434 aa) |
| | yiaE | Putative dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (328 aa) |
| | sgaT | Conserved hypothetical protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (484 aa) |
| | sgaB | Conserved hypothetical protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (101 aa) |
| | ptxA | Putative PTS system enzyme II A component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa) |
| | sgaH | Probable hexulose-6-phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa) |
| | sgaE | Putative epimerase/aldolase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (228 aa) |
| | cysQ | CysQ; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa) |
| | frdD | Fumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa) |
| | frdC | Fumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa) |
| | frdB | Fumarate reductase, anaerobic, iron-sulfur protein subunit; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa) |
| | frdA | Fumarate reductase, anaerobic, flavoprotein subunit; Code: C; COG: COG1053. (602 aa) |
| | serB | 3-phosphoserine phosphatase; Code: E; COG: COG0560. (322 aa) |
| | gpmB | Phosphoglyceromutase 2; Code: G; COG: COG0406; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
