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| | htrA | Periplasmic serine protease Do; Heat shock protein HtrA; Code: O; COG: COG0265; Belongs to the peptidase S1C family. (474 aa) |
| | glnD | Protein PII; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (890 aa) |
| | rcsF | Regulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa) |
| | phoB | Positive response regulator for pho regulon; Sensor is PhoR (or CreC); Code: TK; COG: COG0745. (229 aa) |
| | SDY_0485 | Putative flagellar motor transmembrane channel protein; Code: N; COG: COG1291. (247 aa) |
| | SDY_0506 | Putative response regulator; Hexosephosphate transport; Code: TK; COG: COG2197. (209 aa) |
| | fepA | Outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D; Code: P; COG: COG4771. (746 aa) |
| | gltK | Glutamate/aspartate transport system permease; Code: E; COG: COG0765. (224 aa) |
| | ybeJ | Putative periplasmic binding transport protein; Code: ET; COG: COG0834. (302 aa) |
| | kdpE | Regulator of kdp operon; Transcriptional effector; Code: TK; COG: COG0745. (225 aa) |
| | kdpC | High-affinity potassium transport system; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa) |
| | kdpF | KdpF protein. (29 aa) |
| | cydA | Cytochrome d terminal oxidase, polypeptide subunit I; Code: C; COG: COG1271. (523 aa) |
| | cydB | Cytochrome d terminal oxidase polypeptide subunit II; Code: C; COG: COG1294. (379 aa) |
| | ybgT | Putative outer membrane lipoprotein; Code: S; COG: COG4890. (37 aa) |
| | rcsC | Sensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa) |
| | rcsB | Positive response regulator for colanic capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa) |
| | yojN | Putative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) |
| | ompC | Outer membrane protein 1b; Ib;c; Code: M; COG: COG3203; Belongs to the Gram-negative porin family. (375 aa) |
| | narP | Nitrate/nitrite response regulator; Sensor NarQ; Code: TK; COG: COG2197. (215 aa) |
| | hyaA | Hydrogenase-1 small subunit; Code: C; COG: COG1740. (372 aa) |
| | hyaC | Probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit; Code: C; COG: COG1969. (235 aa) |
| | appC | Probable third cytochrome oxidase, subunit I; Original product: nickel incorporation into hydrogenase-1 proteins. (514 aa) |
| | appB | Probable third cytochrome oxidase, subunit II; Code: C; COG: COG1294. (378 aa) |
| | yccB | Uncharacterized protein; Code: S; COG: COG4890. (30 aa) |
| | yccC | Conserved hypothetical protein; Code: M; COG: COG3206; orf. (726 aa) |
| | yccY | Putative phosphatase; Code: T; COG: COG0394; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (152 aa) |
| | yccZ | Putative function in exopolysaccharide production; Code: M; COG: COG1596. (379 aa) |
| | torR | Response transcriptional regulator for torA; Sensor TorS; Code: TK; COG: COG0745. (230 aa) |
| | torD | Part of trimethylamine-N-oxide oxidoreductase; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (199 aa) |
| | iroN | TonB-dependent outer membrane siderophore receptor protein; Code: P; COG: COG4771. (725 aa) |
| | fliA | Alternative sigma factor 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa) |
| | uvrY | Putative 2-component transcriptional regulator; Code: TK; COG: COG2197. (218 aa) |
| | motA | Proton conductor component of motor; No effect on switching; Code: N; COG: COG1291. (295 aa) |
| | flhC | Regulator of flagellar biosynthesis acting on class 2 operons; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (181 aa) |
| | flhD | Regulator of flagellar biosynthesis, acting on class 2 operons; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa) |
| | narL | NarL; Pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; Code: TK; COG: COG2197. (216 aa) |
| | narX | Nitrate/nitrate sensor; Histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850. (598 aa) |
| | narG | Nitrate reductase 1, alpha subunit; Code: C; COG: COG5013; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa) |
| | narH | Nitrate reductase 1, beta subunit; Code: C; COG: COG1140. (512 aa) |
| | narJ | Nitrate reductase 1, delta subunit, assembly function; Code: C; COG: COG2180. (236 aa) |
| | narI | Nitrate reductase 1, cytochrome b(NR), gamma subunit; Code: C; COG: COG2181. (225 aa) |
| | fdnH | Formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa) |
| | fdnI | Formate dehydrogenase-N, nitrate-inducible, cytochrome B556(Fdn) gamma subunit; Code: C; COG: COG2864. (217 aa) |
| | yneH | Putative glutaminase; Code: E; COG: COG2066; Belongs to the glutaminase family. (308 aa) |
| | narY | Cryptic nitrate reductase 2, beta subunit; Code: C; COG: COG1140. (507 aa) |
| | narW | Cryptic nitrate reductase 2, delta subunit, assembly function; Code: C; COG: COG2180. (231 aa) |
| | narV | Cryptic nitrate reductase 2, gamma subunit; Code: C; COG: COG2181. (226 aa) |
| | safA | Conserved hypothetical protein; Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions; Belongs to the SafA family. (65 aa) |
| | trg | Methyl-accepting chemotaxis protein III; Ribose sensor receptor; Code: NT; COG: COG0840. (477 aa) |
| | rstA | Response transcriptional regulatory protein; RstB sensor; Code: TK; COG: COG0745. (238 aa) |
| | rstB | Sensor histidine protein kinase; RstA regulator; Code: T; COG: COG0642. (433 aa) |
| | phoP | Transcriptional regulatory protein; Code: TK; COG: COG0745. (223 aa) |
| | phoQ | Sensor protein PhoQ; Code: T; COG: COG0642. (486 aa) |
| | flgM | Anti-sigma factor; also known as RflB protein; Code: KNU; COG: COG2747. (97 aa) |
| | baeR | Transcriptional response regulatory protein; Sensor BaeS; Code: TK; COG: COG0745. (240 aa) |
| | baeS | Sensor protein for BaeR; Code: T; COG: COG0642. (467 aa) |
| | yegB | Putative transport protein; Code: GEPR; COG: COG0477. (348 aa) |
| | ompF | Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family. (362 aa) |
| | SDY_2449 | Hypothetical protein. (175 aa) |
| | emrY | Multidrug resistance protein Y; Code: GEPR; COG: COG0477; Belongs to the major facilitator superfamily. (512 aa) |
| | emrK | Multidrug resistance protein K; Code: V; COG: COG1566. (387 aa) |
| | narQ | Sensor for nitrate reductase system; Protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850. (566 aa) |
| | acrD | AcrD; Sensitivity to acriflavine, integral membrane protein, possible efflux pump; Code: V; COG: COG0841. (1037 aa) |
| | glnB | Regulatory protein P-II for glutamine synthetase; Code: E; COG: COG0347; Belongs to the P(II) protein family. (112 aa) |
| | yfhA | Putative 2-component transcriptional regulator; Code: T; COG: COG2204. (444 aa) |
| | yfhK | Putative 2-component sensor protein; Code: T; COG: COG0642. (496 aa) |
| | csrA | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa) |
| | barA | Sensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa) |
| | SDY_3076 | Putative hydrogenase subunit; Code: C; COG: COG1740. (372 aa) |
| | hybC | Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa) |
| | tolC | Outer membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; Code: MU; COG: COG1538. (495 aa) |
| | qseC | Quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642. (449 aa) |
| | ygiX | Putative 2-component transcriptional regulator; Code: TK; COG: COG0745. (219 aa) |
| | aer | Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840. (506 aa) |
| | rpoN | RNA polymerase, sigma(54 or 60) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa) |
| | arcB | Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642. (778 aa) |
| | crp | Cyclic AMP receptor protein; Code: T; COG: COG0664. (210 aa) |
| | ompR | Response regulator affecting transcription of ompC and ompF; Sensor, EnvZ; outer membrane protein synthesis; Code: TK; COG: COG0745. (239 aa) |
| | envZ | Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642. (450 aa) |
| | hydG | Sensor HydH response regulator of hydrogenase 3 activity; Code: T; COG: COG2204. (441 aa) |
| | hydH | Sensor kinase for HydG hydrogenase 3 activity; Code: T; COG: COG0642. (458 aa) |
| | yjaI | Conserved hypothetical protein; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family. (186 aa) |
| | cpxR | Transcriptional regulator in 2-component system; Code: TK; COG: COG0745. (232 aa) |
| | cpxA | Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642. (457 aa) |
| | glnA | Glutamine synthetase; Code: E; COG: COG0174. (469 aa) |
| | glnL | Histidine protein kinase sensor for GlnG regulator; Nitrogen regulator II, NRII; Code: T; COG: COG3852. (349 aa) |
| | glnG | Response regulator for gln; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa) |
| | wecC | UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa) |
| | wecB | UDP-N-acetyl glucosamine -2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (390 aa) |
| | pstS | High-affinity phosphate-specific transport system; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (346 aa) |
| | basS | Sensor protein for basR; Code: T; COG: COG0642. (363 aa) |
| | uhpT | Hexose phosphate transport protein; Code: G; COG: COG2271. (463 aa) |
| | uhpC | Regulator of uhpT; Code: G; COG: COG2271. (440 aa) |
| | uhpB | Sensor histidine protein kinase phosphorylates UhpA; Code: T; COG: COG3851. (501 aa) |
| | uhpA | Response regulator, positive activator of uhpT transcription; Sensor, uhpB; Code: TK; COG: COG2197. (196 aa) |
| | dnaA | DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (467 aa) |
| | dcuB | Anaerobic dicarboxylate transport; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (395 aa) |
| | yjdG | Putative 2-component transcriptional regulator; Code: KT; COG: COG4565. (239 aa) |
| | yjdH | Putative 2-component sensor protein; Code: T; COG: COG3290. (543 aa) |
| | fecI | Probable RNA polymerase sigma factor; Code: K; COG: COG1595; Belongs to the sigma-70 factor family. ECF subfamily. (173 aa) |
| | ampC | Beta-lactamase; Penicillin resistance; Code: V; COG: COG1680. (377 aa) |
| | frdD | Fumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa) |
| | frdC | Fumarate reductase, anaerobic; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa) |
| | frdB | Fumarate reductase, anaerobic, iron-sulfur protein subunit; Code: C; COG: COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa) |
| | frdA | Fumarate reductase, anaerobic, flavoprotein subunit; Code: C; COG: COG1053. (602 aa) |
| | evgA | Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197. (204 aa) |
| | evgS | Putative sensor for regulator EvgA; Code: ET; COG: COG0834. (1197 aa) |
| | dctA | Uptake of C4-dicarboxylic acids; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa) |
| | creB | Catabolic regulation response regulator; Code: TK; COG: COG0745. (229 aa) |
| | arcA | Negative response regulator of genes in aerobic pathways; Sensors, ArcB and CpxA; Code: TK; COG: COG0745. (238 aa) |
