(54 nodes) Inositol phosphate metabolism, and PI3K p85 subunit, N-terminal SH2 domain network (Anopheles merus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182UM08	SAC domain-containing protein. (596 aa)
	A0A182UM17	Uncharacterized protein. (2203 aa)
	A0A182UP61	Uncharacterized protein. (578 aa)
	A0A182UP87	Uncharacterized protein. (755 aa)
	A0A182UQ89	Kinase; Belongs to the inositol phosphokinase (IPK) family. (675 aa)
	A0A182UQG3	PH domain-containing protein. (1403 aa)
	A0A182UQI8	DUF1298 domain-containing protein. (444 aa)
	A0A182UQM9	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (250 aa)
	A0A182UQN4	Uncharacterized protein. (1152 aa)
	A0A182USX5	Myotubularin phosphatase domain-containing protein. (591 aa)
	A0A182UUV8	TPK_B1_binding domain-containing protein. (271 aa)
	A0A182UWT6	Uncharacterized protein. (205 aa)
	A0A182UX16	Uncharacterized protein. (486 aa)
	A0A182UYM1	Uncharacterized protein. (644 aa)
	A0A182UZJ9	Uncharacterized protein. (983 aa)
	A0A182V0R0	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (295 aa)
	A0A182V1P2	C2 NT-type domain-containing protein. (1131 aa)
	A0A182V2D1	Rho-GAP domain-containing protein. (884 aa)
	A0A182V2T7	Uncharacterized protein. (354 aa)
	A0A182V2X5	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (537 aa)
	A0A182V333	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1237 aa)
	A0A182V420	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1989 aa)
	A0A182V4G9	Uncharacterized protein. (1180 aa)
	A0A182V5G1	Uncharacterized protein. (722 aa)
	A0A182V5R9	SAM domain-containing protein. (139 aa)
	A0A182V5Y0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1035 aa)
	A0A182V7B0	Uncharacterized protein. (702 aa)
	A0A182V7C6	Uncharacterized protein. (1879 aa)
	A0A182V8E4	IPPc domain-containing protein. (642 aa)
	A0A182V8I1	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1780 aa)
	A0A182V8M4	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (487 aa)
	A0A182V9M1	Myotubularin phosphatase domain-containing protein. (876 aa)
	A0A182VBA3	Myotubularin phosphatase domain-containing protein. (599 aa)
	A0A182VCV1	IPPc domain-containing protein. (510 aa)
	A0A182VDA8	PH domain-containing protein. (345 aa)
	A0A182VDU3	Uncharacterized protein. (1982 aa)
	A0A182VF99	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa)
	A0A182VFH4	Kinase; Belongs to the inositol phosphokinase (IPK) family. (688 aa)
	A0A182VG96	PIPK domain-containing protein. (1083 aa)
	A0A182VG99	Kinase; Belongs to the inositol phosphokinase (IPK) family. (328 aa)
	A0A182VI20	Uncharacterized protein. (724 aa)
	A0A182VIN9	Uncharacterized protein. (904 aa)
	A0A182VIP6	Uncharacterized protein. (422 aa)
	A0A182VKE3	Phosphoinositide phospholipase C. (2200 aa)
	A0A182VL56	Uncharacterized protein. (715 aa)
	A0A182VNI1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1099 aa)
	A0A182VNQ2	Uncharacterized protein. (871 aa)
	A0A182VPA9	Uncharacterized protein. (298 aa)
	A0A1I8JVE5	Kinase; Belongs to the inositol phosphokinase (IPK) family. (329 aa)
	A0A1I8JVH6	Kinase; Belongs to the inositol phosphokinase (IPK) family. (432 aa)
	A0A2Y9D321	SAC domain-containing protein. (857 aa)
	A0A3F2Z0B8	PI3K/PI4K domain-containing protein. (566 aa)
	A0A3F2Z0C3	PI3K/PI4K domain-containing protein. (594 aa)
	A0A3F2Z0E3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1431 aa)

Your Current Organism:

Anopheles merus

NCBI taxonomy Id: 30066
Other names: A. merus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182UM08	A0A182UP61	SAC domain-containing protein.	Uncharacterized protein.	0.880
A0A182UM08	A0A182UP87	SAC domain-containing protein.	Uncharacterized protein.	0.949
A0A182UM08	A0A182UQI8	SAC domain-containing protein.	DUF1298 domain-containing protein.	0.638
A0A182UM08	A0A182USX5	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.702
A0A182UM08	A0A182UWT6	SAC domain-containing protein.	Uncharacterized protein.	0.702
A0A182UM08	A0A182V1P2	SAC domain-containing protein.	C2 NT-type domain-containing protein.	0.752
A0A182UM08	A0A182V2D1	SAC domain-containing protein.	Rho-GAP domain-containing protein.	0.952
A0A182UM08	A0A182V2T7	SAC domain-containing protein.	Uncharacterized protein.	0.902
A0A182UM08	A0A182V5G1	SAC domain-containing protein.	Uncharacterized protein.	0.432
A0A182UM08	A0A182V5Y0	SAC domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.638
A0A182UM08	A0A182V7C6	SAC domain-containing protein.	Uncharacterized protein.	0.944
A0A182UM08	A0A182V8E4	SAC domain-containing protein.	IPPc domain-containing protein.	0.956
A0A182UM08	A0A182V8I1	SAC domain-containing protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.959
A0A182UM08	A0A182V9M1	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.908
A0A182UM08	A0A182VBA3	SAC domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.919
A0A182UM08	A0A182VCV1	SAC domain-containing protein.	IPPc domain-containing protein.	0.965
A0A182UM08	A0A182VDU3	SAC domain-containing protein.	Uncharacterized protein.	0.915
A0A182UM08	A0A182VG96	SAC domain-containing protein.	PIPK domain-containing protein.	0.930
A0A182UM08	A0A182VIN9	SAC domain-containing protein.	Uncharacterized protein.	0.734
A0A182UM08	A0A182VKE3	SAC domain-containing protein.	Phosphoinositide phospholipase C.	0.899