(26 nodes) HDACs deacetylate histones, and Notch-HLH transcription pathway network (Anopheles stephensi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182XW50	Uncharacterized protein. (171 aa)
	A0A182XXP7	MBD domain-containing protein. (304 aa)
	A0A182Y178	Attacin_C domain-containing protein. (578 aa)
	A0A182Y1T4	Uncharacterized protein. (661 aa)
	A0A182Y3J3	Uncharacterized protein. (911 aa)
	A0A182Y6Z0	Amine oxidase. (533 aa)
	A0A182Y7V6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (491 aa)
	A0A182YB34	Uncharacterized protein. (711 aa)
	A0A182YB35	Uncharacterized protein. (583 aa)
	A0A182YBR9	Uncharacterized protein. (2168 aa)
	A0A182YBY3	Uncharacterized protein. (392 aa)
	A0A182YCT4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1212 aa)
	A0A182YGX7	HDAC_interact domain-containing protein. (2187 aa)
	A0A182YHK4	Uncharacterized protein. (597 aa)
	A0A182YI02	HMG box domain-containing protein. (327 aa)
	A0A182YI53	SANT domain-containing protein. (769 aa)
	A0A182YJB5	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (869 aa)
	A0A182YJN8	Uncharacterized protein. (979 aa)
	A0A182YJN9	Uncharacterized protein. (64 aa)
	A0A182YMY1	Histone deacetylase. (921 aa)
	A0A182YMY2	UBP-type domain-containing protein. (201 aa)
	A0A182YNC5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (433 aa)
	A0A182YP86	Uncharacterized protein. (1103 aa)
	A0A182YR71	Uncharacterized protein. (2357 aa)
	A0A182YRT6	Integrase catalytic domain-containing protein. (262 aa)
	A0A182YRY3	Uncharacterized protein. (504 aa)

Your Current Organism:

Anopheles stephensi

NCBI taxonomy Id: 30069
Other names: A. stephensi, Anopheles mysorensis, Anopheles stephensi mysorensis, Anopheles stephensi var. mysorensis, Asian malaria mosquito

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182XW50	A0A182XXP7	Uncharacterized protein.	MBD domain-containing protein.	0.855
A0A182XW50	A0A182Y178	Uncharacterized protein.	Attacin_C domain-containing protein.	0.791
A0A182XW50	A0A182Y1T4	Uncharacterized protein.	Uncharacterized protein.	0.556
A0A182XW50	A0A182Y7V6	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.696
A0A182XW50	A0A182YB34	Uncharacterized protein.	Uncharacterized protein.	0.556
A0A182XW50	A0A182YB35	Uncharacterized protein.	Uncharacterized protein.	0.556
A0A182XW50	A0A182YBR9	Uncharacterized protein.	Uncharacterized protein.	0.785
A0A182XW50	A0A182YCT4	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.463
A0A182XW50	A0A182YJN8	Uncharacterized protein.	Uncharacterized protein.	0.782
A0A182XW50	A0A182YJN9	Uncharacterized protein.	Uncharacterized protein.	0.695
A0A182XW50	A0A182YMY1	Uncharacterized protein.	Histone deacetylase.	0.463
A0A182XW50	A0A182YMY2	Uncharacterized protein.	UBP-type domain-containing protein.	0.463
A0A182XW50	A0A182YNC5	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.696
A0A182XW50	A0A182YP86	Uncharacterized protein.	Uncharacterized protein.	0.719
A0A182XW50	A0A182YRT6	Uncharacterized protein.	Integrase catalytic domain-containing protein.	0.693
A0A182XXP7	A0A182XW50	MBD domain-containing protein.	Uncharacterized protein.	0.855
A0A182XXP7	A0A182Y178	MBD domain-containing protein.	Attacin_C domain-containing protein.	0.949
A0A182XXP7	A0A182Y1T4	MBD domain-containing protein.	Uncharacterized protein.	0.809
A0A182XXP7	A0A182Y3J3	MBD domain-containing protein.	Uncharacterized protein.	0.488
A0A182XXP7	A0A182Y6Z0	MBD domain-containing protein.	Amine oxidase.	0.635

page 1 of 27

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About