(60 nodes) Nucleic acid-binding, OB-fold network (Anopheles stephensi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A182Y5Z7	AAA domain-containing protein; Belongs to the AAA ATPase family. (425 aa)
	A0A182Y5X9	Uncharacterized protein. (476 aa)
	A0A182Y582	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (619 aa)
	A0A182Y526	Uncharacterized protein; Belongs to the ATP-dependent DNA ligase family. (923 aa)
	A0A182Y4I5	Uncharacterized protein. (116 aa)
	A0A182Y4A2	AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
	A0A182Y498	Tyrosine--tRNA ligase. (545 aa)
	A0A182Y458	Uncharacterized protein. (960 aa)
	A0A182Y3B8	RPA_C domain-containing protein. (244 aa)
	A0A182Y342	CSD_1 domain-containing protein. (397 aa)
	A0A182Y2L5	Uncharacterized protein. (146 aa)
	A0A182Y286	Uncharacterized protein. (1894 aa)
	A0A182Y1H7	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	A0A182Y199	CSD_1 domain-containing protein. (101 aa)
	A0A182Y144	AA_TRNA_LIGASE_II domain-containing protein. (543 aa)
	A0A182XZ37	Uncharacterized protein. (431 aa)
	A0A182XYR5	DIS3-like exonuclease 2; Belongs to the RNR ribonuclease family. (1223 aa)
	A0A182XX32	DNA helicase; Belongs to the MCM family. (902 aa)
	A0A182XWV6	Single-stranded DNA-binding protein. (135 aa)
	A0A182XWD2	AA_TRNA_LIGASE_II domain-containing protein. (553 aa)
	A0A182XVL9	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (148 aa)
	A0A182XUX0	AAA domain-containing protein; Belongs to the AAA ATPase family. (463 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (717 aa)
	A0A182YJ53	Ribosomal_L2_C domain-containing protein. (261 aa)
	A0A182YIX3	S1 motif domain-containing protein. (755 aa)
	A0A182YMM9	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	A0A182YML3	Uncharacterized protein. (1281 aa)
	A0A182YLP8	Mcm10 domain-containing protein. (793 aa)
	A0A182YLB6	Uncharacterized protein. (230 aa)
	A0A182YLB4	Uncharacterized protein; Belongs to the RNR ribonuclease family. (961 aa)
	A0A182YKR3	Uncharacterized protein. (968 aa)
	A0A182YK32	Lysine--tRNA ligase. (588 aa)
	A0A182YJV4	Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (110 aa)
	A0A182YJT5	MCM domain-containing protein; Belongs to the MCM family. (963 aa)
	A0A182YB38	AAA domain-containing protein; Belongs to the AAA ATPase family. (434 aa)
	A0A182YAF3	Uncharacterized protein. (218 aa)
	A0A182YA42	tRNA-binding domain-containing protein. (331 aa)
	A0A182Y9W0	DNA ligase. (897 aa)
	A0A182Y908	DNA helicase; Belongs to the MCM family. (733 aa)
	A0A182Y7P2	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	A0A182YIQ6	Ribosomal_L2_C domain-containing protein. (297 aa)
	A0A182YIJ9	S1-like domain-containing protein. (177 aa)
	A0A182YIA6	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1828 aa)
	A0A182YHF8	KH_dom_type_1 domain-containing protein. (238 aa)
	A0A182YHC6	DNA helicase; Belongs to the MCM family. (816 aa)
	A0A182YGG7	AAA domain-containing protein; Belongs to the AAA ATPase family. (392 aa)
	A0A182YFK8	Uncharacterized protein. (155 aa)
	A0A182YED0	S1 motif domain-containing protein. (341 aa)
	A0A182YEB2	S1 motif domain-containing protein. (297 aa)
	A0A182YC75	Uncharacterized protein. (245 aa)
	A0A182YBG9	AA_TRNA_LIGASE_II domain-containing protein. (472 aa)
	A0A182YTE0	EXOSC1 domain-containing protein. (129 aa)
	A0A182YR51	DNA helicase; Belongs to the MCM family. (876 aa)
	A0A182YNQ8	Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (608 aa)
	A0A182YNB6	DNA helicase; Belongs to the MCM family. (820 aa)
	A0A182Y7C1	S1 motif domain-containing protein. (1509 aa)
	A0A182Y6V5	Eukaryotic translation initiation factor 5A. (160 aa)
	A0A182Y6G9	Uncharacterized protein. (683 aa)
	A0A182Y6G8	MCM domain-containing protein; Belongs to the MCM family. (712 aa)
	A0A182Y694	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family. (152 aa)

Your Current Organism:

Anopheles stephensi

NCBI taxonomy Id: 30069
Other names: A. stephensi, Anopheles mysorensis, Anopheles stephensi mysorensis, Anopheles stephensi var. mysorensis, Asian malaria mosquito

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A182XUX0	A0A182Y4A2	A0A182XUX0	A0A182Y4A2	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.993
A0A182XUX0	A0A182Y5Z7	A0A182XUX0	A0A182Y5Z7	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.988
A0A182XUX0	A0A182Y694	A0A182XUX0	A0A182Y694	AAA domain-containing protein; Belongs to the AAA ATPase family.	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	0.509
A0A182XUX0	A0A182Y7P2	A0A182XUX0	A0A182Y7P2	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.988
A0A182XUX0	A0A182YB38	A0A182XUX0	A0A182YB38	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.996
A0A182XUX0	A0A182YGG7	A0A182XUX0	A0A182YGG7	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.995
A0A182XUX0	A0A182YJ53	A0A182XUX0	A0A182YJ53	AAA domain-containing protein; Belongs to the AAA ATPase family.	Ribosomal_L2_C domain-containing protein.	0.508
A0A182XUX0	A0A182YMM9	A0A182XUX0	A0A182YMM9	AAA domain-containing protein; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.996
A0A182XVL9	A0A182XWV6	A0A182XVL9	A0A182XWV6	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Single-stranded DNA-binding protein.	0.863
A0A182XVL9	A0A182Y199	A0A182XVL9	A0A182Y199	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	CSD_1 domain-containing protein.	0.527
A0A182XVL9	A0A182Y2L5	A0A182XVL9	A0A182Y2L5	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Uncharacterized protein.	0.527
A0A182XVL9	A0A182Y342	A0A182XVL9	A0A182Y342	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	CSD_1 domain-containing protein.	0.527
A0A182XVL9	A0A182Y498	A0A182XVL9	A0A182Y498	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Tyrosine--tRNA ligase.	0.786
A0A182XVL9	A0A182Y4I5	A0A182XVL9	A0A182Y4I5	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Uncharacterized protein.	0.995
A0A182XVL9	A0A182Y694	A0A182XVL9	A0A182Y694	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.	0.999
A0A182XVL9	A0A182Y6V5	A0A182XVL9	A0A182Y6V5	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Eukaryotic translation initiation factor 5A.	0.954
A0A182XVL9	A0A182Y7C1	A0A182XVL9	A0A182Y7C1	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	S1 motif domain-containing protein.	0.524
A0A182XVL9	A0A182YAF3	A0A182XVL9	A0A182YAF3	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Uncharacterized protein.	0.999
A0A182XVL9	A0A182YED0	A0A182XVL9	A0A182YED0	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	S1 motif domain-containing protein.	0.998
A0A182XVL9	A0A182YIJ9	A0A182XVL9	A0A182YIJ9	S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	S1-like domain-containing protein.	0.516

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