STRINGSTRING
hisG hisG hisD hisD hisB hisB hisE hisE CUM80372.1 CUM80372.1 CUM91822.1 CUM91822.1 CUM92972.1 CUM92972.1 hisF hisF hisH1 hisH1 CUN14643.1 CUN14643.1 hisC hisC CUN07350.1 CUN07350.1 hisK hisK CUN11619.1 CUN11619.1 CUN19962.1 CUN19962.1 CUM74526.1 CUM74526.1 CUM77039.1 CUM77039.1 hisZ hisZ CUN15210.1 CUN15210.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa)
hisBImidazoleglycerol-phosphate dehydratase. (196 aa)
hisEPhosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. (427 aa)
CUM80372.1Uncharacterised protein. (118 aa)
CUM91822.1Transposase IS116/IS110/IS902 family. (402 aa)
CUM92972.1Transposase IS116/IS110/IS902 family. (389 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisH1Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa)
CUN14643.1PEGA domain. (415 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa)
CUN07350.11-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m ethylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (271 aa)
hisKHistidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (256 aa)
CUN11619.1Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (268 aa)
CUN19962.1Transposase IS116/IS110/IS902 family. (408 aa)
CUM74526.1Transposase IS116/IS110/IS902 family. (475 aa)
CUM77039.1Uncharacterised protein. (215 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (397 aa)
CUN15210.1Transposase IS116/IS110/IS902 family. (391 aa)
Your Current Organism:
Roseburia faecis
NCBI taxonomy Id: 301302
Other names: DSM 16840, NCIMB 14031, R. faecis, Roseburia faecis Duncan et al. 2006, strain M72/1
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