(29 nodes) Clathrin coat, and Clathrin-dependent synaptic vesicle endocytosis network (Pundamilia nyererei)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (206 aa)
	LOC102196119	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (922 aa)
	gak	Cyclin G associated kinase. (1239 aa)
	eps15l1	Epidermal growth factor receptor pathway substrate 15-like 1a. (944 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (358 aa)
	LOC102209389	Epsin 3b. (596 aa)
	LOC102201583	Epidermal growth factor receptor pathway substrate 15 like 1. (825 aa)
	eps15	Epidermal growth factor receptor pathway substrate 15. (949 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	LOC102204860	Adaptor related protein complex 4 subunit beta 1. (452 aa)
	LOC102192340	Growth arrest specific 7. (337 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)
	ENSPNYP00000012098	ENTH domain-containing protein. (112 aa)
	cep135	Centrosomal protein 135. (1172 aa)
	ENSPNYP00000014196	UBA domain-containing protein. (207 aa)
	LOC102197773	Growth arrest-specific 7a. (345 aa)
	LOC102192735	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1621 aa)
	itsn1	Intersectin 1 (SH3 domain protein). (1584 aa)
	hip1	Huntingtin interacting protein 1. (1011 aa)
	ENSPNYP00000018481	Uncharacterized protein. (522 aa)
	ENSPNYP00000018534	Uncharacterized protein. (512 aa)
	ENSPNYP00000022803	Uncharacterized protein. (514 aa)
	synrg	Synergin, gamma. (1416 aa)
	ENSPNYP00000022967	Uncharacterized protein. (1059 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (220 aa)
	epn2	Epsin 2. (352 aa)
	ENSPNYP00000025621	ENTH domain-containing protein. (143 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000012098	ENSPNYP00000014196	ENSPNYP00000012098	ENSPNYP00000014196	ENTH domain-containing protein.	UBA domain-containing protein.	0.675
ENSPNYP00000012098	ENSPNYP00000018481	ENSPNYP00000012098	ENSPNYP00000018481	ENTH domain-containing protein.	Uncharacterized protein.	0.885
ENSPNYP00000012098	ENSPNYP00000018534	ENSPNYP00000012098	ENSPNYP00000018534	ENTH domain-containing protein.	Uncharacterized protein.	0.885
ENSPNYP00000012098	ENSPNYP00000022803	ENSPNYP00000012098	ENSPNYP00000022803	ENTH domain-containing protein.	Uncharacterized protein.	0.885
ENSPNYP00000012098	ENSPNYP00000022967	ENSPNYP00000012098	ENSPNYP00000022967	ENTH domain-containing protein.	Uncharacterized protein.	0.885
ENSPNYP00000012098	LOC102192340	ENSPNYP00000012098	ENSPNYP00000010800	ENTH domain-containing protein.	Growth arrest specific 7.	0.487
ENSPNYP00000012098	LOC102192735	ENSPNYP00000012098	ENSPNYP00000015539	ENTH domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.843
ENSPNYP00000012098	LOC102196119	ENSPNYP00000012098	ENSPNYP00000004444	ENTH domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.876
ENSPNYP00000012098	LOC102197773	ENSPNYP00000012098	ENSPNYP00000015092	ENTH domain-containing protein.	Growth arrest-specific 7a.	0.487
ENSPNYP00000012098	LOC102201583	ENSPNYP00000012098	ENSPNYP00000009801	ENTH domain-containing protein.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.938
ENSPNYP00000012098	LOC102204860	ENSPNYP00000012098	ENSPNYP00000010689	ENTH domain-containing protein.	Adaptor related protein complex 4 subunit beta 1.	0.695
ENSPNYP00000012098	ap2m1	ENSPNYP00000012098	ENSPNYP00000005788	ENTH domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.772
ENSPNYP00000012098	ap2s1	ENSPNYP00000012098	ENSPNYP00000024998	ENTH domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.667
ENSPNYP00000012098	cep135	ENSPNYP00000012098	ENSPNYP00000014026	ENTH domain-containing protein.	Centrosomal protein 135.	0.738
ENSPNYP00000012098	clta	ENSPNYP00000012098	ENSPNYP00000025267	ENTH domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.821
ENSPNYP00000012098	cltb	ENSPNYP00000012098	ENSPNYP00000000274	ENTH domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.821
ENSPNYP00000012098	cltc	ENSPNYP00000012098	ENSPNYP00000029047	ENTH domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.843
ENSPNYP00000012098	cltcl1	ENSPNYP00000012098	ENSPNYP00000010256	ENTH domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.843
ENSPNYP00000012098	epn2	ENSPNYP00000012098	ENSPNYP00000025597	ENTH domain-containing protein.	Epsin 2.	0.894
ENSPNYP00000012098	eps15	ENSPNYP00000012098	ENSPNYP00000009830	ENTH domain-containing protein.	Epidermal growth factor receptor pathway substrate 15.	0.945