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hprt1 hprt1 nme5 nme5 CMPK1 CMPK1 atic atic ENSPNYP00000000930 ENSPNYP00000000930 adss1 adss1 LOC102201772 LOC102201772 LOC102194436 LOC102194436 dck dck LOC102202649 LOC102202649 LOC102205301 LOC102205301 LOC102205073 LOC102205073 LOC102194769 LOC102194769 entpd1 entpd1 prtfdc1 prtfdc1 LOC102204513 LOC102204513 LOC102213715 LOC102213715 LOC102198139 LOC102198139 LOC102192715 LOC102192715 ENSPNYP00000004635 ENSPNYP00000004635 hddc3 hddc3 nudt2 nudt2 nt5c2 nt5c2 RRM2 RRM2 RRM2-2 RRM2-2 LOC102204927 LOC102204927 ak5 ak5 LOC102197051 LOC102197051 LOC102198668 LOC102198668 entpd8 entpd8 ENSPNYP00000007481 ENSPNYP00000007481 ENSPNYP00000007533 ENSPNYP00000007533 NT5M NT5M rrm1 rrm1 ak6 ak6 pfas pfas LOC102214887 LOC102214887 LOC102213408 LOC102213408 LOC102198928 LOC102198928 OLA1 OLA1 aprt aprt itpa itpa ak1 ak1 ampd3 ampd3 ak2 ak2 ENSPNYP00000013403 ENSPNYP00000013403 ENSPNYP00000013555 ENSPNYP00000013555 ENSPNYP00000013565 ENSPNYP00000013565 ppat ppat LOC102198930 LOC102198930 LOC102203849 LOC102203849 dalrd3 dalrd3 impdh2 impdh2 gmps gmps NT5C3B NT5C3B LOC102198754 LOC102198754 LOC102212638 LOC102212638 LOC102197573 LOC102197573 gmpr gmpr nt5c3a nt5c3a LOC102205505 LOC102205505 entpd6 entpd6 pde1a pde1a ak3 ak3 thtpa thtpa ENSPNYP00000017521 ENSPNYP00000017521 ntpcr ntpcr ak8 ak8 ampd1 ampd1 ENSPNYP00000018400 ENSPNYP00000018400 ENSPNYP00000018428 ENSPNYP00000018428 LOC102212509 LOC102212509 ak4 ak4 entpd4 entpd4 pde1b pde1b LOC102204634 LOC102204634 guk1 guk1 NT5C3B-2 NT5C3B-2 LOC102209121 LOC102209121 LOC102214069 LOC102214069 LOC102208744 LOC102208744 LOC102197099 LOC102197099 ENSPNYP00000023031 ENSPNYP00000023031 LOC102201197 LOC102201197 ENSPNYP00000024828 ENSPNYP00000024828 LOC102204985 LOC102204985 nme7 nme7 ADK ADK LOC102195721 LOC102195721 cant1 cant1 lrguk lrguk ENSPNYP00000028001 ENSPNYP00000028001 tpk1 tpk1 LOC102203503 LOC102203503 entpd5 entpd5 LOC102196784 LOC102196784 LOC102207681 LOC102207681 ENTPD7 ENTPD7 LOC102194616 LOC102194616 LOC102205225 LOC102205225 ENSPNYP00000031808 ENSPNYP00000031808
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hprt1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
nme5NME/NM23 family member 5; Belongs to the NDK family. (218 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (219 aa)
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
ENSPNYP00000000930Uncharacterized protein. (549 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
LOC102201772NME/NM23 family member 8; Belongs to the NDK family. (487 aa)
LOC102194436Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (542 aa)
dckDeoxycytidine kinase. (329 aa)
LOC102202649Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (449 aa)
LOC102205301Ectonucleoside triphosphate diphosphohydrolase 5b; Belongs to the GDA1/CD39 NTPase family. (430 aa)
LOC102205073Adenylate kinase 7a. (615 aa)
LOC1021947695'-nucleotidase, cytosolic IAb. (371 aa)
entpd1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (498 aa)
prtfdc1Un-named sa821. (208 aa)
LOC102204513Calcium activated nucleotidase 1b. (436 aa)
LOC1022137155'-nucleotidase, cytosolic IIa. (558 aa)
LOC102198139Zgc:110540. (296 aa)
LOC102192715GTP cyclohydrolase 2. (221 aa)
ENSPNYP00000004635Phosphodiesterase 4C, cAMP-specific a; Belongs to the cyclic nucleotide phosphodiesterase family. (325 aa)
hddc3HD domain containing 3. (179 aa)
nudt2Nudix (nucleoside diphosphate linked moiety X)-type motif 2. (149 aa)
nt5c25'-nucleotidase, cytosolic IIb. (545 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (385 aa)
RRM2-2Ribonucleotide reductase regulatory subunit M2. (385 aa)
LOC102204927Phosphodiesterase. (485 aa)
ak5Adenylate kinase 5; Belongs to the adenylate kinase family. (559 aa)
LOC1021970515'-nucleotidase, cytosolic IAa. (387 aa)
LOC102198668GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
entpd8Ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2; Belongs to the GDA1/CD39 NTPase family. (503 aa)
ENSPNYP00000007481Uncharacterized protein. (183 aa)
ENSPNYP00000007533Adenosine monophosphate deaminase 2b. (590 aa)
NT5M5',3'-nucleotidase, mitochondrial. (229 aa)
rrm1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (174 aa)
pfasPhosphoribosylformylglycinamidine synthase. (1062 aa)
LOC102214887Nucleoside diphosphate kinase. (208 aa)
LOC102213408AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (898 aa)
LOC102198928Phosphodiesterase. (677 aa)
OLA1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (398 aa)
aprtAdenine phosphoribosyltransferase. (181 aa)
itpaInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (205 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (193 aa)
ampd3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (758 aa)
ak2Adenylate kinase 2; Belongs to the adenylate kinase family. (247 aa)
ENSPNYP00000013403Uncharacterized protein. (306 aa)
ENSPNYP00000013555Uncharacterized protein. (172 aa)
ENSPNYP00000013565AIRC domain-containing protein. (425 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (509 aa)
LOC102198930CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (592 aa)
LOC102203849Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (495 aa)
dalrd3DALR anticodon binding domain containing 3. (568 aa)
impdh2IMP (inosine 5'-monophosphate) dehydrogenase 2. (535 aa)
gmpsGuanine monophosphate synthase. (690 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (333 aa)
LOC102198754Uncharacterized protein. (260 aa)
LOC1022126385'-nucleotidase, cytosolic II, like 1. (496 aa)
LOC102197573AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa)
gmprGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
LOC102205505Ribonucleotide reductase M2 b. (349 aa)
entpd6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (440 aa)
pde1aPhosphodiesterase. (548 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
thtpaThiamine triphosphatase. (259 aa)
ENSPNYP00000017521Uncharacterized protein. (95 aa)
ntpcrNucleoside-triphosphatase, cancer-related. (198 aa)
ak8Adenylate kinase 8; Belongs to the adenylate kinase family. (449 aa)
ampd1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (737 aa)
ENSPNYP00000018400dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (150 aa)
ENSPNYP00000018428Uncharacterized protein. (80 aa)
LOC102212509Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (513 aa)
ak4GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
entpd4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (621 aa)
pde1bPhosphodiesterase. (518 aa)
LOC102204634Deoxyguanosine kinase. (316 aa)
guk1Guanylate kinase 1a. (197 aa)
NT5C3B-25'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (317 aa)
LOC102209121Mannosidase, endo-alpha. (440 aa)
LOC102214069Phosphodiesterase. (523 aa)
LOC102208744Zgc:152951. (376 aa)
LOC102197099Phosphodiesterase. (768 aa)
ENSPNYP00000023031Thiopurine S-methyltransferase, tandem duplicate 1. (110 aa)
LOC102201197Ectonucleoside triphosphate diphosphohydrolase 2b; Belongs to the GDA1/CD39 NTPase family. (505 aa)
ENSPNYP00000024828Adenylosuccinate lyase. (294 aa)
LOC102204985Ribonucleotide reductase M1 polypeptide. (571 aa)
nme7Nucleoside diphosphate kinase. (402 aa)
ADKAdenosine kinase. (357 aa)
LOC102195721Zgc:112492. (590 aa)
cant1Calcium activated nucleotidase 1a. (427 aa)
lrgukLeucine-rich repeats and guanylate kinase domain containing. (558 aa)
ENSPNYP00000028001SAICAR_synt domain-containing protein. (92 aa)
tpk1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (274 aa)
LOC102203503Adenylate kinase 7b. (664 aa)
entpd5Ectonucleoside triphosphate diphosphohydrolase 5a; Belongs to the GDA1/CD39 NTPase family. (402 aa)
LOC102196784Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (473 aa)
LOC102207681Ectonucleotide pyrophosphatase/phosphodiesterase 1. (795 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (605 aa)
LOC1021946165'-nucleotidase, cytosolic IB b. (361 aa)
LOC102205225Uncharacterized protein. (794 aa)
ENSPNYP00000031808Uncharacterized protein. (60 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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