(97 nodes) Methyltransferase complex network (Pundamilia nyererei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	men1	Multiple endocrine neoplasia I. (568 aa)
	pagr1	PAXIP1 associated glutamate-rich protein 1. (292 aa)
	trmt61a	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (296 aa)
	KMT2A	Lysine methyltransferase 2A. (4558 aa)
	LOC102198965	Uncharacterized protein. (170 aa)
	wdr82	WD repeat domain 82. (313 aa)
	pelp1	Proline, glutamate and leucine rich protein 1. (1036 aa)
	ino80c	INO80 complex subunit C. (203 aa)
	taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (638 aa)
	tex10	Testis expressed 10. (943 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2519 aa)
	RAMAC	RNA guanine-7 methyltransferase activating subunit. (129 aa)
	virma	Vir like m6A methyltransferase associated. (1786 aa)
	ENSPNYP00000024619	Uncharacterized protein. (115 aa)
	ENSPNYP00000024628	Uncharacterized protein. (273 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
	wdr5	WD repeat domain 5. (333 aa)
	phf20	PHD finger protein 20, a. (951 aa)
	rbm15b	RNA binding motif protein 15B. (845 aa)
	ash2l	Ash2 like, histone lysine methyltransferase complex subunit. (590 aa)
	LOC102193867	Lysine (K)-specific demethylase 6B, b. (1577 aa)
	LOC102197162	Retinoblastoma binding protein 4, like. (427 aa)
	ENSPNYP00000026314	Uncharacterized protein. (116 aa)
	cbll1	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (477 aa)
	rnf2	Ring finger protein 2. (342 aa)
	mcrs1	Microspherule protein 1. (466 aa)
	ENSPNYP00000026964	Uncharacterized protein. (289 aa)
	mettl1	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (245 aa)
	LOC102202355	CXXC finger protein 1a. (568 aa)
	ruvbl2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
	LOC102192979	Lysine (K)-specific demethylase 6A, like. (1435 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (594 aa)
	clns1a	Chloride channel, nucleotide-sensitive, 1A. (230 aa)
	ENSPNYP00000028858	Small nuclear ribonucleoprotein polypeptide F. (85 aa)
	ENSPNYP00000028977	Uncharacterized protein. (676 aa)
	ENSPNYP00000029011	Uncharacterized protein. (394 aa)
	ENSPNYP00000029302	Uncharacterized protein. (144 aa)
	MAX	MYC associated factor X. (150 aa)
	rbbp5	Retinoblastoma binding protein 5. (578 aa)
	wtap	WT1 associated protein. (421 aa)
	hsd17b10	Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	mettl14	Methyltransferase like 14; Belongs to the MT-A70-like family. (462 aa)
	wdr4	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (414 aa)
	n6amt1	N-6 adenine-specific DNA methyltransferase 1. (218 aa)
	trmt61b	tRNA methyltransferase 61B. (487 aa)
	RING1	Ring finger protein 1. (395 aa)
	ENSPNYP00000028965	Uncharacterized protein. (245 aa)
	LOC102202766	Myc associated factor X. (184 aa)
	znf335	Zinc finger protein 335. (1415 aa)
	LOC102200361	WD_REPEATS_REGION domain-containing protein. (254 aa)
	AEBP2	AE binding protein 2. (452 aa)
	trmt6	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (443 aa)
	LOC102211021	Si:ch211-195d17.2. (386 aa)
	ncoa6	Nuclear receptor coactivator 6. (2402 aa)
	ENSPNYP00000001687	Uncharacterized protein. (245 aa)
	kdm6b	Lysine (K)-specific demethylase 6B, a. (2185 aa)
	LOC102192429	Retinoblastoma binding protein 4. (424 aa)
	prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast). (507 aa)
	ENSPNYP00000002906	PHD-type domain-containing protein. (230 aa)
	ENSPNYP00000002942	Metal response element binding transcription factor 2. (317 aa)
	suz12	SUZ12 polycomb repressive complex 2 subunit b. (691 aa)
	ENSPNYP00000003679	Uncharacterized protein. (393 aa)
	ENSPNYP00000004638	tRNA methyltransferase 10C, mitochondrial RNase P subunit. (429 aa)
	LOC102207849	Zgc:103508. (205 aa)
	riok1	RIO kinase 1 (yeast). (313 aa)
	ENSPNYP00000006417	Uncharacterized protein. (156 aa)
	rbm15	RNA binding motif protein 15. (862 aa)
	snrpe	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	ruvbl1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	prdm4	PR domain containing 4. (775 aa)
	WDR77	WD repeat domain 77. (337 aa)
	ENSPNYP00000009794	Uncharacterized protein. (849 aa)
	eed	Embryonic ectoderm development. (402 aa)
	LOC102197833	BHLH domain-containing protein. (2787 aa)
	ENSPNYP00000012513	BRCT domain-containing protein. (136 aa)
	setd1b	SET domain containing 1B, histone lysine methyltransferase a. (1800 aa)
	LOC102206399	WD_REPEATS_REGION domain-containing protein. (315 aa)
	LOC102201540	Lysine (K)-specific methyltransferase 2Ba. (2892 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (769 aa)
	LOC102214525	VEFS-Box domain-containing protein. (735 aa)
	snrpd1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (202 aa)
	snrpd2	Small nuclear ribonucleoprotein Sm D2. (118 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1451 aa)
	jarid2	Jumonji, AT rich interactive domain 2b. (1440 aa)
	ENSPNYP00000016093	Uncharacterized protein. (1084 aa)
	ENSPNYP00000016219	Uncharacterized protein. (410 aa)
	kmt2b	Lysine (K)-specific methyltransferase 2Bb. (3541 aa)
	ENSPNYP00000017231	PHD finger protein 1. (296 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (692 aa)
	setd1a	SET domain containing 1A, histone lysine methyltransferase. (2194 aa)
	phf19	PHD finger protein 19. (556 aa)
	snrpb	Small nuclear ribonucleoprotein-associated protein. (240 aa)
	LOC102196723	AE binding protein 2. (460 aa)
	hcfc2	Host cell factor C2. (761 aa)
	cxxc1	CXXC finger protein 1b. (538 aa)
	dpy30	Dpy-30 histone methyltransferase complex regulatory subunit. (104 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEBP2	ENSPNYP00000002906	ENSPNYP00000001102	ENSPNYP00000002906	AE binding protein 2.	PHD-type domain-containing protein.	0.674
AEBP2	ENSPNYP00000002942	ENSPNYP00000001102	ENSPNYP00000002942	AE binding protein 2.	Metal response element binding transcription factor 2.	0.674
AEBP2	ENSPNYP00000017231	ENSPNYP00000001102	ENSPNYP00000017231	AE binding protein 2.	PHD finger protein 1.	0.704
AEBP2	EZH1	ENSPNYP00000001102	ENSPNYP00000013094	AE binding protein 2.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.954
AEBP2	LOC102192429	ENSPNYP00000001102	ENSPNYP00000002198	AE binding protein 2.	Retinoblastoma binding protein 4.	0.890
AEBP2	LOC102192979	ENSPNYP00000001102	ENSPNYP00000028306	AE binding protein 2.	Lysine (K)-specific demethylase 6A, like.	0.544
AEBP2	LOC102193867	ENSPNYP00000001102	ENSPNYP00000025762	AE binding protein 2.	Lysine (K)-specific demethylase 6B, b.	0.599
AEBP2	LOC102197162	ENSPNYP00000001102	ENSPNYP00000026313	AE binding protein 2.	Retinoblastoma binding protein 4, like.	0.890
AEBP2	LOC102200361	ENSPNYP00000001102	ENSPNYP00000001011	AE binding protein 2.	WD_REPEATS_REGION domain-containing protein.	0.890
AEBP2	LOC102214525	ENSPNYP00000001102	ENSPNYP00000013433	AE binding protein 2.	VEFS-Box domain-containing protein.	0.955
AEBP2	eed	ENSPNYP00000001102	ENSPNYP00000011012	AE binding protein 2.	Embryonic ectoderm development.	0.978
AEBP2	ezh2	ENSPNYP00000001102	ENSPNYP00000017782	AE binding protein 2.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.954
AEBP2	ino80c	ENSPNYP00000001102	ENSPNYP00000023486	AE binding protein 2.	INO80 complex subunit C.	0.401
AEBP2	jarid2	ENSPNYP00000001102	ENSPNYP00000015871	AE binding protein 2.	Jumonji, AT rich interactive domain 2b.	0.980
AEBP2	kdm6a	ENSPNYP00000001102	ENSPNYP00000015678	AE binding protein 2.	Lysine (K)-specific demethylase 6A.	0.544
AEBP2	kdm6b	ENSPNYP00000001102	ENSPNYP00000001926	AE binding protein 2.	Lysine (K)-specific demethylase 6B, a.	0.600
AEBP2	phf19	ENSPNYP00000001102	ENSPNYP00000019235	AE binding protein 2.	PHD finger protein 19.	0.674
AEBP2	ruvbl1	ENSPNYP00000001102	ENSPNYP00000007440	AE binding protein 2.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.450
AEBP2	suz12	ENSPNYP00000001102	ENSPNYP00000002995	AE binding protein 2.	SUZ12 polycomb repressive complex 2 subunit b.	0.955
AEBP2	taf6	ENSPNYP00000001102	ENSPNYP00000023779	AE binding protein 2.	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.431