(28 nodes) Telomeric DNA binding network (Pundamilia nyererei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	smg6	SMG6 nonsense mediated mRNA decay factor. (1476 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
	ctc1	Uncharacterized protein. (827 aa)
	smg7	SMG7 nonsense mediated mRNA decay factor. (1184 aa)
	LOC102207120	Homeobox containing 1a. (408 aa)
	ENSPNYP00000014555	Protection of telomeres 1 homolog. (485 aa)
	upf3a	UPF3A regulator of nonsense mediated mRNA decay. (481 aa)
	smg5	SMG5 nonsense mediated mRNA decay factor. (1129 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	LOC102215177	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	UPF2	UPF2 regulator of nonsense mediated mRNA decay. (1246 aa)
	ENSPNYP00000023059	TEN1 subunit of CST complex. (133 aa)
	LOC102202405	HTH myb-type domain-containing protein. (706 aa)
	LOC102202112	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (497 aa)
	stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
	LOC102195152	Zgc:91944. (489 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (645 aa)
	smg1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3577 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1473 aa)
	ENSPNYP00000006725	TINF2_N domain-containing protein. (110 aa)
	ENSPNYP00000024966	Uncharacterized protein. (364 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (723 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (785 aa)
	hmbox1	Homeobox containing 1. (510 aa)
	ENSPNYP00000028537	BTB domain-containing protein. (338 aa)
	ENSPNYP00000006741	TINF2_N domain-containing protein. (450 aa)
	ENSPNYP00000006833	Uncharacterized protein. (255 aa)
	ENSPNYP00000009147	Uncharacterized protein. (487 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000006725	ENSPNYP00000006833	ENSPNYP00000006725	ENSPNYP00000006833	TINF2_N domain-containing protein.	Uncharacterized protein.	0.542
ENSPNYP00000006725	ENSPNYP00000009147	ENSPNYP00000006725	ENSPNYP00000009147	TINF2_N domain-containing protein.	Uncharacterized protein.	0.987
ENSPNYP00000006725	ENSPNYP00000014555	ENSPNYP00000006725	ENSPNYP00000014555	TINF2_N domain-containing protein.	Protection of telomeres 1 homolog.	0.981
ENSPNYP00000006725	ENSPNYP00000023059	ENSPNYP00000006725	ENSPNYP00000023059	TINF2_N domain-containing protein.	TEN1 subunit of CST complex.	0.758
ENSPNYP00000006725	ENSPNYP00000024966	ENSPNYP00000006725	ENSPNYP00000024966	TINF2_N domain-containing protein.	Uncharacterized protein.	0.960
ENSPNYP00000006725	LOC102202112	ENSPNYP00000006725	ENSPNYP00000024314	TINF2_N domain-containing protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.963
ENSPNYP00000006725	LOC102202405	ENSPNYP00000006725	ENSPNYP00000024284	TINF2_N domain-containing protein.	HTH myb-type domain-containing protein.	0.963
ENSPNYP00000006725	LOC102215177	ENSPNYP00000006725	ENSPNYP00000021640	TINF2_N domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.591
ENSPNYP00000006725	RPA1	ENSPNYP00000006725	ENSPNYP00000032019	TINF2_N domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.591
ENSPNYP00000006725	ctc1	ENSPNYP00000006725	ENSPNYP00000009223	TINF2_N domain-containing protein.	Uncharacterized protein.	0.778
ENSPNYP00000006725	rad50	ENSPNYP00000006725	ENSPNYP00000020424	TINF2_N domain-containing protein.	RAD50 homolog, double strand break repair protein.	0.542
ENSPNYP00000006725	stn1	ENSPNYP00000006725	ENSPNYP00000024430	TINF2_N domain-containing protein.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.817
ENSPNYP00000006741	ENSPNYP00000006833	ENSPNYP00000006741	ENSPNYP00000006833	TINF2_N domain-containing protein.	Uncharacterized protein.	0.542
ENSPNYP00000006741	ENSPNYP00000009147	ENSPNYP00000006741	ENSPNYP00000009147	TINF2_N domain-containing protein.	Uncharacterized protein.	0.987
ENSPNYP00000006741	ENSPNYP00000014555	ENSPNYP00000006741	ENSPNYP00000014555	TINF2_N domain-containing protein.	Protection of telomeres 1 homolog.	0.981
ENSPNYP00000006741	ENSPNYP00000023059	ENSPNYP00000006741	ENSPNYP00000023059	TINF2_N domain-containing protein.	TEN1 subunit of CST complex.	0.758
ENSPNYP00000006741	ENSPNYP00000024966	ENSPNYP00000006741	ENSPNYP00000024966	TINF2_N domain-containing protein.	Uncharacterized protein.	0.960
ENSPNYP00000006741	LOC102202112	ENSPNYP00000006741	ENSPNYP00000024314	TINF2_N domain-containing protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.963
ENSPNYP00000006741	LOC102202405	ENSPNYP00000006741	ENSPNYP00000024284	TINF2_N domain-containing protein.	HTH myb-type domain-containing protein.	0.969
ENSPNYP00000006741	LOC102215177	ENSPNYP00000006741	ENSPNYP00000021640	TINF2_N domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.591