(28 nodes) Defense response to Gram-negative bacterium network (Pundamilia nyererei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tusc2	Tumor suppressor 2, mitochondrial calcium regulator. (109 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (310 aa)
	LOC102209707	Uncharacterized protein. (241 aa)
	LOC102208844	TNFR-Cys domain-containing protein. (317 aa)
	rpl30	Ribosomal protein L30. (116 aa)
	LOC102205879	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (242 aa)
	MPEG1	Macrophage expressed 1. (709 aa)
	LOC102198411	TIR domain-containing protein. (944 aa)
	ENSPNYP00000005963	BPI1 domain-containing protein. (120 aa)
	LOC102194393	Uncharacterized protein. (480 aa)
	ENSPNYP00000004443	Uncharacterized protein. (293 aa)
	ENSPNYP00000003915	CARD domain-containing protein. (96 aa)
	ENSPNYP00000002549	CARD domain-containing protein. (113 aa)
	ENSPNYP00000001202	Uncharacterized protein. (285 aa)
	LOC102201372	Uncharacterized protein. (169 aa)
	drosha	Drosha ribonuclease III. (1345 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (347 aa)
	ENSPNYP00000028376	Uncharacterized protein. (178 aa)
	LOC102200345	Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (611 aa)
	ENSPNYP00000001832	Uncharacterized protein. (218 aa)
	LOC102207201	Uncharacterized protein; Belongs to the peptidase S1 family. (440 aa)
	LOC102207304	MACPF domain-containing protein. (717 aa)
	LOC102212478	Tumor suppressor 2, mitochondrial calcium regulator b. (111 aa)
	LOC102207805	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (276 aa)
	LOC102207533	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (290 aa)
	LOC102210654	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (267 aa)
	LOC102208853	Interleukin 17a/f1. (155 aa)
	LOC102208575	Uncharacterized protein. (151 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNYP00000005963	LOC102194393	ENSPNYP00000005963	ENSPNYP00000005942	BPI1 domain-containing protein.	Uncharacterized protein.	0.810
ENSPNYP00000005963	LOC102198411	ENSPNYP00000005963	ENSPNYP00000009930	BPI1 domain-containing protein.	TIR domain-containing protein.	0.567
ENSPNYP00000028376	LOC102208575	ENSPNYP00000028376	ENSPNYP00000025301	Uncharacterized protein.	Uncharacterized protein.	0.920
ENSPNYP00000028376	LOC102208853	ENSPNYP00000028376	ENSPNYP00000025314	Uncharacterized protein.	Interleukin 17a/f1.	0.862
IL12B	il12b	ENSPNYP00000021970	ENSPNYP00000000210	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.854
LOC102194393	ENSPNYP00000005963	ENSPNYP00000005942	ENSPNYP00000005963	Uncharacterized protein.	BPI1 domain-containing protein.	0.810
LOC102194393	LOC102198411	ENSPNYP00000005942	ENSPNYP00000009930	Uncharacterized protein.	TIR domain-containing protein.	0.567
LOC102198411	ENSPNYP00000005963	ENSPNYP00000009930	ENSPNYP00000005963	TIR domain-containing protein.	BPI1 domain-containing protein.	0.567
LOC102198411	LOC102194393	ENSPNYP00000009930	ENSPNYP00000005942	TIR domain-containing protein.	Uncharacterized protein.	0.567
LOC102200345	LOC102205879	ENSPNYP00000027585	ENSPNYP00000013543	Coagulation factor II (thrombin); Belongs to the peptidase S1 family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.539
LOC102200345	LOC102207201	ENSPNYP00000027585	ENSPNYP00000027446	Coagulation factor II (thrombin); Belongs to the peptidase S1 family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.809
LOC102205879	LOC102200345	ENSPNYP00000013543	ENSPNYP00000027585	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Coagulation factor II (thrombin); Belongs to the peptidase S1 family.	0.539
LOC102205879	LOC102207201	ENSPNYP00000013543	ENSPNYP00000027446	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.539
LOC102207201	LOC102200345	ENSPNYP00000027446	ENSPNYP00000027585	Uncharacterized protein; Belongs to the peptidase S1 family.	Coagulation factor II (thrombin); Belongs to the peptidase S1 family.	0.809
LOC102207201	LOC102205879	ENSPNYP00000027446	ENSPNYP00000013543	Uncharacterized protein; Belongs to the peptidase S1 family.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.539
LOC102208575	ENSPNYP00000028376	ENSPNYP00000025301	ENSPNYP00000028376	Uncharacterized protein.	Uncharacterized protein.	0.920
LOC102208575	LOC102208853	ENSPNYP00000025301	ENSPNYP00000025314	Uncharacterized protein.	Interleukin 17a/f1.	0.916
LOC102208853	ENSPNYP00000028376	ENSPNYP00000025314	ENSPNYP00000028376	Interleukin 17a/f1.	Uncharacterized protein.	0.862
LOC102208853	LOC102208575	ENSPNYP00000025314	ENSPNYP00000025301	Interleukin 17a/f1.	Uncharacterized protein.	0.916
il12b	IL12B	ENSPNYP00000000210	ENSPNYP00000021970	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.854