(17 nodes) Neuron cellular homeostasis network (Pundamilia nyererei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102208384	Dynactin 1a. (1239 aa)
	LOC102197046	Uncharacterized protein. (253 aa)
	ca7	Carbonic anhydrase VII; Belongs to the alpha-carbonic anhydrase family. (262 aa)
	stil	STIL centriolar assembly protein. (930 aa)
	immt	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (732 aa)
	tmem175	Transmembrane protein 175. (521 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (425 aa)
	LOC102197725	Calbindin 2a. (268 aa)
	ENSPNYP00000018083	Uncharacterized protein. (570 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	CALB2	Calbindin 2. (255 aa)
	hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (390 aa)
	LOC102198008	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
	dctn1	Dynactin 1b. (1057 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (384 aa)
	sod1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	SCGN	Secretagogin, EF-hand calcium binding protein. (271 aa)

Your Current Organism:

Pundamilia nyererei

NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALB2	sod1	ENSPNYP00000019904	ENSPNYP00000030692	Calbindin 2.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.453
ENSPNYP00000018083	immt	ENSPNYP00000018083	ENSPNYP00000007245	Uncharacterized protein.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.494
LOC102197046	sod1	ENSPNYP00000003730	ENSPNYP00000030692	Uncharacterized protein.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.453
LOC102197725	sod1	ENSPNYP00000013591	ENSPNYP00000030692	Calbindin 2a.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.453
LOC102198008	ccnd1	ENSPNYP00000023923	ENSPNYP00000018834	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin D1; Belongs to the cyclin family.	0.810
LOC102198008	hdac8	ENSPNYP00000023923	ENSPNYP00000023060	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.530
LOC102198008	p2rx1	ENSPNYP00000023923	ENSPNYP00000028716	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.535
LOC102208384	sod1	ENSPNYP00000002270	ENSPNYP00000030692	Dynactin 1a.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.816
SCGN	sod1	ENSPNYP00000031434	ENSPNYP00000030692	Secretagogin, EF-hand calcium binding protein.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.453
ccnd1	LOC102198008	ENSPNYP00000018834	ENSPNYP00000023923	Cyclin D1; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.810
ccnd1	hdac8	ENSPNYP00000018834	ENSPNYP00000023060	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.530
ccnd1	p2rx1	ENSPNYP00000018834	ENSPNYP00000028716	Cyclin D1; Belongs to the cyclin family.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.535
dctn1	sod1	ENSPNYP00000027897	ENSPNYP00000030692	Dynactin 1b.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.816
hdac8	LOC102198008	ENSPNYP00000023060	ENSPNYP00000023923	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.530
hdac8	ccnd1	ENSPNYP00000023060	ENSPNYP00000018834	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Cyclin D1; Belongs to the cyclin family.	0.530
hdac8	prkn	ENSPNYP00000023060	ENSPNYP00000012053	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.635
immt	ENSPNYP00000018083	ENSPNYP00000007245	ENSPNYP00000018083	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Uncharacterized protein.	0.494
p2rx1	LOC102198008	ENSPNYP00000028716	ENSPNYP00000023923	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.535
p2rx1	ccnd1	ENSPNYP00000028716	ENSPNYP00000018834	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Cyclin D1; Belongs to the cyclin family.	0.535
prkn	hdac8	ENSPNYP00000012053	ENSPNYP00000023060	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.635