STRINGSTRING
ENSPNYP00000005006 ENSPNYP00000005006 ENSPNYP00000005212 ENSPNYP00000005212 psmd5 psmd5 mybl2 mybl2 lin54 lin54 orc1 orc1 LOC102207966 LOC102207966 psmb7 psmb7 psmb4 psmb4 ENSPNYP00000007911 ENSPNYP00000007911 ENSPNYP00000007971 ENSPNYP00000007971 psmb3 psmb3 fndc3b fndc3b ppp4r4 ppp4r4 ppp2r3a ppp2r3a LOC102205859 LOC102205859 SRC SRC LOC102206726 LOC102206726 ppp4r1 ppp4r1 mcm8 mcm8 ENSPNYP00000009163 ENSPNYP00000009163 LOC102205309 LOC102205309 cdkn1b cdkn1b abl1 abl1 mcm7 mcm7 LOC102192516 LOC102192516 ccnd3 ccnd3 psmd8 psmd8 LOC102213633 LOC102213633 ENSPNYP00000010639 ENSPNYP00000010639 cdt1 cdt1 cdc45 cdc45 E2F3 E2F3 ENSPNYP00000011737 ENSPNYP00000011737 ENSPNYP00000011760 ENSPNYP00000011760 psma3 psma3 LOC102192275 LOC102192275 ENSPNYP00000012893 ENSPNYP00000012893 fndc3a fndc3a LOC102203937 LOC102203937 ENSPNYP00000013697 ENSPNYP00000013697 ENSPNYP00000013716 ENSPNYP00000013716 psma4 psma4 LOC102209955 LOC102209955 psmc5 psmc5 ENSPNYP00000014364 ENSPNYP00000014364 rpa3 rpa3 psmd2 psmd2 psma1 psma1 PPP2R3B PPP2R3B LOC102201528 LOC102201528 gmnn gmnn wee1 wee1 psmb8 psmb8 LOC102199990 LOC102199990 LOC102199716 LOC102199716 LOC102200259 LOC102200259 LOC102213074 LOC102213074 lin37 lin37 ppp2ca ppp2ca skp1 skp1 psme1 psme1 ccna1 ccna1 LOC102213697 LOC102213697 ENSPNYP00000017722 ENSPNYP00000017722 cables2 cables2 psma2 psma2 psmd9 psmd9 rpa2 rpa2 ccnd1 ccnd1 LOC102192785 LOC102192785 dyrk1a dyrk1a tfdp1 tfdp1 psmc6 psmc6 e2f1 e2f1 mcm4 mcm4 ENSPNYP00000020080 ENSPNYP00000020080 ENSPNYP00000020122 ENSPNYP00000020122 LOC102197382 LOC102197382 mcm10 mcm10 LOC102195846 LOC102195846 pola2 pola2 LOC102209424 LOC102209424 LOC102215177 LOC102215177 uba52 uba52 mcm6 mcm6 psmc3 psmc3 psmb1 psmb1 pole pole orc2 orc2 LOC102193347 LOC102193347 LOC102199580 LOC102199580 pole2 pole2 orc5 orc5 LOC106456278 LOC106456278 psma5 psma5 psmd3 psmd3 prr5l prr5l ppp2r1b ppp2r1b cdc25b cdc25b LOC102198008 LOC102198008 psmd12 psmd12 e2f2 e2f2 psmc2 psmc2 cables1 cables1 LOC102205387 LOC102205387 rb1 rb1 cdk6 cdk6 cdk7 cdk7 PSMD11 PSMD11 LOC102196183 LOC102196183 prim2 prim2 e2f4 e2f4 LOC102210818 LOC102210818 ENSPNYP00000026279 ENSPNYP00000026279 cdk2 cdk2 rps27a rps27a ccne1 ccne1 orc3 orc3 cdk4 cdk4 wee2 wee2 ccnh ccnh ENSPNYP00000027448 ENSPNYP00000027448 meiob meiob prim1 prim1 mcm3 mcm3 psmd1 psmd1 ENSPNYP00000028654 ENSPNYP00000028654 fnbp4 fnbp4 pole4 pole4 ENSPNYP00000028993 ENSPNYP00000028993 LOC102203088 LOC102203088 lin52 lin52 LOC102199978 LOC102199978 mnat1 mnat1 psmc1 psmc1 psme2 psme2 psmc4 psmc4 relch relch orc4 orc4 LOC102210430 LOC102210430 mcm2 mcm2 psma6 psma6 ppp2r3c ppp2r3c LOC102192865 LOC102192865 cdc6 cdc6 skp2 skp2 ENSPNYP00000031331 ENSPNYP00000031331 LOC102207217 LOC102207217 cdkn2d cdkn2d ENSPNYP00000031825 ENSPNYP00000031825 RPA1 RPA1 ENSPNYP00000000172 ENSPNYP00000000172 LOC102201640 LOC102201640 LOC102199590 LOC102199590 pola1 pola1 ENSPNYP00000000493 ENSPNYP00000000493 psmd14 psmd14 akt1 akt1 LOC102207116 LOC102207116 LOC102209997 LOC102209997 psmd6 psmd6 LOC102200915 LOC102200915 LOC102205503 LOC102205503 psmd13 psmd13 psme3 psme3 LOC102196756 LOC102196756 cdc7 cdc7 ENSPNYP00000002795 ENSPNYP00000002795 kxd1 kxd1 psmb2 psmb2 pole3 pole3 LOC102209059 LOC102209059 ENSPNYP00000004124 ENSPNYP00000004124 LOC102200298 LOC102200298 psmd7 psmd7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPNYP00000005006THAP-type domain-containing protein. (360 aa)
ENSPNYP00000005212Ubiquitin-like domain-containing protein. (114 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
mybl2V-myb avian myeloblastosis viral oncogene homolog-like 2b. (595 aa)
lin54Lin-54 DREAM MuvB core complex component. (805 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (783 aa)
LOC102207966Proteasome 26S subunit, non-ATPase 4b. (375 aa)
psmb7Proteasome subunit beta. (286 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
ENSPNYP00000007911Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
ENSPNYP00000007971DBF4-type domain-containing protein. (430 aa)
psmb3Proteasome subunit beta. (205 aa)
fndc3bFibronectin type III domain containing 3Ba. (1204 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (865 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1402 aa)
LOC102205859Uncharacterized protein. (178 aa)
SRCTyrosine-protein kinase. (464 aa)
LOC102206726Uncharacterized protein. (181 aa)
ppp4r1WRNPLPNID domain-containing protein. (1015 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (838 aa)
ENSPNYP00000009163Metallophos domain-containing protein. (129 aa)
LOC102205309Proteasome subunit beta. (278 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
abl1Tyrosine-protein kinase. (1112 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa)
LOC102192516Cyclin-dependent kinase inhibitor 1A. (169 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (254 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
LOC102213633Cyclin-dependent kinase inhibitor 1Cb. (208 aa)
ENSPNYP00000010639Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
cdt1Chromatin licensing and DNA replication factor 1. (486 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (522 aa)
E2F3E2F transcription factor 3. (445 aa)
ENSPNYP00000011737E2F_TDP domain-containing protein. (84 aa)
ENSPNYP00000011760Uncharacterized protein. (137 aa)
psma3Proteasome subunit alpha type. (255 aa)
LOC102192275Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (131 aa)
ENSPNYP00000012893Lin-9 DREAM MuvB core complex component. (278 aa)
fndc3aFibronectin type III domain containing 3A. (1237 aa)
LOC102203937Proteasome 26S subunit, non-ATPase 4a. (377 aa)
ENSPNYP00000013697E2F_TDP domain-containing protein. (81 aa)
ENSPNYP00000013716E2F_CC-MB domain-containing protein. (127 aa)
psma4Proteasome subunit alpha type. (261 aa)
LOC102209955Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (89 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (407 aa)
ENSPNYP00000014364RB_B domain-containing protein. (183 aa)
rpa3Replication protein A3. (122 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
psma1Proteasome subunit alpha type. (263 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (581 aa)
LOC102201528HTH myb-type domain-containing protein. (559 aa)
gmnnGeminin DNA replication inhibitor. (208 aa)
wee1Wee1-like protein kinase. (619 aa)
psmb8Proteasome subunit beta. (279 aa)
LOC102199990Proteasome subunit beta. (275 aa)
LOC102199716Proteasome subunit beta 12. (217 aa)
LOC102200259Proteasome subunit beta. (216 aa)
LOC102213074Tyrosine-protein kinase. (1120 aa)
lin37Lin-37 DREAM MuvB core complex component. (242 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
psme1Proteasome activator subunit 1. (301 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (389 aa)
LOC102213697Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ENSPNYP00000017722Cullin 1b; Belongs to the cullin family. (370 aa)
cables2Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (414 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
rpa2Replication protein A2. (293 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC102192785Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (713 aa)
dyrk1aDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (742 aa)
tfdp1Transcription factor. (413 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
e2f1E2F transcription factor 1. (409 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
ENSPNYP00000020080E2F_TDP domain-containing protein. (138 aa)
ENSPNYP00000020122Uncharacterized protein. (133 aa)
LOC102197382Proteasome subunit beta 6. (221 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (806 aa)
LOC102195846Cyclin E2; Belongs to the cyclin family. (380 aa)
pola2Polymerase (DNA directed), alpha 2. (565 aa)
LOC102209424Cyclin Dx; Belongs to the cyclin family. (296 aa)
LOC102215177Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
uba52Ubiquitin-like domain-containing protein. (128 aa)
mcm6DNA helicase; Belongs to the MCM family. (825 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
psmb1Proteasome subunit beta. (237 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2015 aa)
orc2Origin recognition complex, subunit 2. (429 aa)
LOC102193347Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
LOC102199580Cyclin D2, b; Belongs to the cyclin family. (294 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (509 aa)
orc5Origin recognition complex, subunit 5. (404 aa)
LOC106456278Ubiquitin-like domain-containing protein. (122 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (562 aa)
prr5lUncharacterized protein. (356 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (589 aa)
cdc25bCell division cycle 25B. (540 aa)
LOC102198008Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
e2f2Si:ch211-160f23.5. (415 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
cables1Cdk5 and Abl enzyme substrate 1. (540 aa)
LOC102205387Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (431 aa)
rb1Retinoblastoma 1. (862 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
PSMD11PCI domain-containing protein. (422 aa)
LOC102196183Proteasome subunit beta. (281 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
e2f4E2F transcription factor 4. (379 aa)
LOC102210818Cyclin D2, a; Belongs to the cyclin family. (297 aa)
ENSPNYP00000026279Cdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (191 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
rps27aRibosomal protein S27a. (188 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (432 aa)
orc3Origin recognition complex, subunit 3. (705 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (318 aa)
wee2Wee1-like protein kinase. (541 aa)
ccnhCyclin H; Belongs to the cyclin family. (343 aa)
ENSPNYP00000027448Protein kinase domain-containing protein. (102 aa)
meiobMethionine sulfoxide reductase B1b. (456 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (951 aa)
ENSPNYP00000028654Uncharacterized protein. (295 aa)
fnbp4Formin binding protein 4. (818 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
ENSPNYP00000028993SCY domain-containing protein. (124 aa)
LOC102203088Tyrosine-protein kinase. (537 aa)
lin52Lin-52 DREAM MuvB core complex component. (154 aa)
LOC102199978Proteasome subunit alpha type. (246 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
psme2Proteasome activator subunit 2. (245 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1196 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
LOC102210430Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
psma6Proteasome subunit alpha type. (246 aa)
ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (462 aa)
LOC102192865Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (434 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (396 aa)
ENSPNYP00000031331PH domain-containing protein. (146 aa)
LOC102207217Tyrosine-protein kinase. (515 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
ENSPNYP00000031825Proteasome 26S subunit, non-ATPase 10. (138 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
ENSPNYP00000000172ANK_REP_REGION domain-containing protein. (102 aa)
LOC102201640Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
LOC102199590Serine/threonine-protein phosphatase. (309 aa)
pola1DNA polymerase. (1364 aa)
ENSPNYP00000000493Uncharacterized protein. (80 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
LOC102207116Cyclin A2; Belongs to the cyclin family. (440 aa)
LOC102209997Proteasome 26S subunit, non-ATPase 11b. (422 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (392 aa)
LOC102200915Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
LOC102205503Proteasome subunit alpha type. (248 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC102196756Retinoblastoma-like 2 (p130). (1075 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (510 aa)
ENSPNYP00000002795Uncharacterized protein. (183 aa)
kxd1KxDL motif containing 1. (184 aa)
psmb2Proteasome subunit beta. (199 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
LOC102209059Retinoblastoma-like 1 (p107). (1006 aa)
ENSPNYP00000004124Proteasome inhibitor subunit 1. (236 aa)
LOC102200298Tyrosine-protein kinase. (1122 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (332 aa)
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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